DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grin2bb

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	762	Identity:	143/762 - (18%)
Similarity:	263/762 - (34%)	Gaps:	219/762 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIVAFISLAMATSIPIPIANPAPLSGYEMQLKILLQKILWVA---------NVKRCF-----AVI 57
            :|:.:.:...||:| ..:|:...|:||         ...|:.         ||...|     :|.
Zfish   301 VILLYCTKEEATTI-FEVAHSVGLTGY---------GYTWIVPSLVAGDTDNVPNVFPTGLISVS 355

  Fly    58 TDDLHYPIYDRIFFESVGRRVIPFFVMRTN------------ESDDLQRPSRQVELFVKAIKSSD 110
            .|:..|.:..|:      |..:....|.|:            :|.....|.:      |..||.:
Zfish   356 YDEWDYGLEARV------RDAVAIIAMATSTMMLDRGPHTLLKSGCHGAPDK------KGSKSGN 408

  Fly   111 CELNVITILNGWQVQRFLGYIYDNRSLNMQKKFVLLHDLRLFE----------SDMIHLW---SV 162
            ....:..::|.....|.|.:..|...::.:...:||:..|.:|          :...|:|   .:
Zfish   409 PNEVLRYLMNVTFEGRNLSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMKYHVWPRFEL 473

  Fly   163 FIDAIFLKRQLDNKYTISTI-AFPGI-------LSGVLVMKNIANWELGKGLNGRILFADKTSNL 219
            :.||   :.:.|:..:|.|: ..|.:       |||..:...:   ...|.|        |..||
Zfish   474 YSDA---EEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTV---PCRKQL--------KLQNL 524

  Fly   220 FGTSLPVAISEHVPMVLWANATKSFQGVEVEIMNALGKALNFKPVYY-----KPNQTENMDWTEL 279
            .|.| .:.|.            :..:|..::|:..:.|::.|....|     |..:..|..|
Zfish   525 TGDS-GIYIK------------RCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHGKKINGTW--- 573

  Fly   280 DGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLT 344
                              ||      :|.||...:|..|:|.|.:.:...::::.|.|.....::
Zfish   574 ------------------NG------MVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGIS 614

  Fly   345 FLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTV-FYAISFLNAIINGNVSSEFFRCLRPNR 408
            .:...|:...|...|:.||||.:||.:.:.|.:|..| .:...:.:.:       .:.|||...|
Zfish   615 VMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV-------GYNRCLADGR 672

  Fly   409 NVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP-RMPRNWPLRV 472
            . |..|      ||.|.                     ..|.|.:.::...::| :.|:....::
Zfish   673 E-PGGP------SFTIG---------------------KAIWLLWGLVFNNSVPVQNPKGTTSKI 709

  Fly   473 LTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLRSH----IPP------STGATEN-- 525
            :...:..:.::.:|:|.|:..|.:........:..|.|....|    .||      ..|:||.
Zfish   710 MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTERNI 774

  Fly   526 RQFFLEANDEVA----RKVGE--------KMEVFGYSDDLTSRIAKGQCAYYDNEFYLRYLRVAD 578
            |..:.|.:..:.    :.|.|        |::.|.|                 :...|.|:...|
Zfish   775 RNNYKEMHSYMTSFHQKNVNEALHSLKSGKLDAFIY-----------------DAAVLNYMAGRD 822

  Fly   579 ESGSALHIMKECVLYMPV--VLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAE 637
            | |..|..:....::...  .:|::|:|..|..||.:|..|...|    |.|.||.....:...|
Zfish   823 E-GCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWLTGICHNEKNE 886

  Fly   638 ALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAER---WHFKHIVM 681
            .::.|   :::......|..|.....:|::|.:||.   |..:...|
Zfish   887 VMSSQ---LDVDNMAGVFYMLGAAMALSLITFIAEHLFYWQLRFCFM 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	46/262 (18%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	34/190 (18%)
		ANF_receptor	138..442	CDD:279440	28/162 (17%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	97/503 (19%)
		Lig_chan	636..908	CDD:278489	60/327 (18%)
		NMDAR2_C	919..1770	CDD:287527	2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591158
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740