DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grik4

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	591	Identity:	120/591 - (20%)
Similarity:	224/591 - (37%)	Gaps:	126/591 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 NRSLNMQKKFVLLHDLRLFE---SDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVMK 195
            |||.|:....:.....:::|   |.|.:|..|.::.:....:.::|...|..|...:.:....::
Zfish   323 NRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALRIMQNSRDGLR 387

  Fly   196 NIANW--ELGKGLNGRILFADKTSNLFGTSLPV-AISEHVPMVLWAN-----ATKSFQGVEVEIM 252
            .|..|  |.|..:..::...:.|..||.|:|.: .|.|:..::|.||     ....::|..|:::
Zfish   388 QIGQWHSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQELEGNDRYEGFCVDML 452

  Fly   253 NALGKALNFK--------PVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDE 309
            ..|...|.||        .||..|.  .|..||.                           :|.|
Zfish   453 KELADILKFKYRIRLVGDGVYGVPG--ANGTWTG---------------------------MVGE 488

  Fly   310 VAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPESS--------TDNSWQTFILPFSAG 366
            :.:..|..|:..|.:.....|:::.|.|       |:|...|        ....:.:|:.|||.|
Zfish   489 LISRKADLAVAALTITAEREKVIDFSKP-------FMTLGISIMYRVHIGRRPGYFSFLDPFSPG 546

  Fly   367 MWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRS 431
            :|:.:||:...|..|.:.::.|..          :....|:      |.:..|.|  :.|::|..
Zfish   547 VWLFMLLAYLAVSCVLFLVARLTP----------YEWYNPH------PCLKGRCS--LLINQYSL 593

  Fly   432 SKGDRMPRDLFDGYTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAIL 496
            ......|...|....:.|              .||....|.::|.:|.:.::::::|.|:..|.|
Zfish   594 GNSFWFPVGGFMQQGSTI--------------APRALSTRCVSGVWWAFTLIIISSYTANLAAFL 644

  Fly   497 ANPAARVTIDTLEDLL-RSHIPPST---GATENRQFFLEANDEVARKV-----GEKMEVFGYS-D 551
            ......|.|::::||. ::.|...|   |:|  ..||..:..:..:::     .::..||..| :
Zfish   645 TVQRMEVPIESVDDLADQTAIEYGTMHGGST--MTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTE 707

  Fly   552 DLTSRIAKGQCAYY----DNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDA 612
            :..:|:.....||.    .||:|.:......:.|..|. .|...:.||:      .|..:...|.
Zfish   708 EGIARVLNSNYAYLLESTMNEYYRQRNCNLTQIGGLLD-TKGYGIGMPL------GSVYRDEFDL 765

  Fly   613 SIQHLAEGG----LIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISM-LTLLAE 672
            :|..|.|..    |..||....  ..|.|...:.:.| .::.....||.|:.|.:::: :.:|..
Zfish   766 AILRLQEENRLEILKRKWWDGG--KCPKEEDHRAKGL-GMENIGGIFVVLVCGLLVAIFMAVLEF 827

  Fly   673 RWHFKH 678
            .|..:|
Zfish   828 VWMLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	51/249 (20%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	16/76 (21%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	88/436 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740