DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and grik2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	734	Identity:	137/734 - (18%)
Similarity:	247/734 - (33%)	Gaps:	216/734 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GYEMQLKILLQKILWVANVKRCFAVITDDLHYPIYDRIF------------FESVGRRVIPFFVM 84
            |:||...||.|.:        ...::|:..||     ||            :...|..:..|.::
Zfish   231 GHEMAAGILKQAL--------AMGMMTEYYHY-----IFTTLDLFALDVEPYRYSGVNMTGFRIL 282

  Fly    85 RTNES-----------DDLQRPSRQVELFVKAIKSSDCEL-----NVITI---------LNGWQV 124
            .|..|           :.||.|.:.....:....::|..|     :|:.:         ::..|.
Zfish   283 NTENSQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQSPQITVSSLQC 347

  Fly   125 QRFLGYIYDNRSLNMQKK-----------FVLLHDLRL-FESDMIHLWSVFIDAIFLKRQLDNKY 177
            .|...:.:.||.:.:.|:           |...:.||. |:          :|.|.||.:
Zfish   348 NRHKPWRFGNRFMTLIKEAHWDGLTGRINFNRTNGLRTDFD----------LDVISLKEE----- 397

  Fly   178 TISTIAFPGILSGVLVMKNIANWELGKGLN------GRILFADKTSNLFGTSLPVAISEHVPMVL 236
                           .::.|..|:...|||      |:.  |:.|.:|...||.|:.....|.|:
Zfish   398 ---------------GLEKIGTWDPASGLNMTENQKGKT--ANVTDSLSNRSLVVSTILEEPYVM 445

  Fly   237 WANATK------SFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGY 295
            :..:.|      .|:|..|:::..|...|.|.   |:....|       ||    .||:.:....
Zfish   446 FKKSDKPLYGNDRFEGYCVDLLRELAAILGFG---YELRLVE-------DG----RYGAQDESSG 496

  Fly   296 AQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESST 352
            ..||      :|.|:..|.|..|:..|.:..|..|:::.|.|       |:|        ..:.|
Zfish   497 QWNG------MVRELMDHKADLAVAPLAITYVREKVIDFSKP-------FMTLGISILYRKPNGT 548

  Fly   353 DNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIY 417
            :....:|:.|.|..:|:.:||:...|..|.:.|:..:.          :....|:   |.:|
Zfish   549 NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSP----------YEWYNPH---PCNP--- 597

  Fly   418 RRISFRIAISRYRSSKGDRMPRDLFD-GYT--NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWI 479
                                ..|:.: .:|  |........|:......||:....|::.|.:|.
Zfish   598 --------------------DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWF 642

  Fly   480 YCILLVATYRASFTAILANPAARVTIDTLEDLLRSHIPPSTGATEN---RQFFLEANDEVARKVG 541
            :.::::::|.|:..|.|........||:.:||.: ......|..|:   ..||.:.......|:.
Zfish   643 FTLIIISSYTANLAAFLTVERMESPIDSADDLAK-QTKIEYGVVEDGSTMTFFKKTKISTYDKMW 706

  Fly   542 EKMEVFGYS------DDLTSRIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAM 600
            |.|....:|      ::...|:.....|:......:.::           ..:.|.|.....|..
Zfish   707 EFMSSRRHSVMVKSIEEGIERVLTSDYAFLMESTTIEFV-----------TQRNCNLTQIGGLID 760

  Fly   601 EK--------NSALKPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWS 653
            .|        .|..:.::..:|..|.|.|.:    .||.:.  ...|.|...:..|| .:|....
Zfish   761 SKAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRG--NGCPEEENKEASAL-GVQNIGG 822

  Fly   654 SFVALLIGYVISMLTLLAE 672
            .|:.|..|.|:|:...:.|
Zfish   823 IFIVLAAGLVLSVFVAVGE 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	45/255 (18%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	39/225 (17%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	83/444 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840