DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grin2da

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	495	Identity:	99/495 - (20%)
Similarity:	180/495 - (36%)	Gaps:	121/495 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 ISEHVPMVLWANATKSFQGVE----------VEIMNALGKALNFK-PVYYKPNQTENMDWTELDG 281
            |.:.||..|..|.:...:|::          ::::..|.|.:.|. .:|...|
Zfish   479 IRDSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFTYDLYLVTN------------ 531

  Fly   282 GASVAYGSGNPDGYAQNGTHIDSM---LVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECL 343
                          .::|.:||..   :|.||.:..|..|||.|.:.:...::||.|.|.....:
Zfish   532 --------------GRHGKNIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGI 582

  Fly   344 TFLTPESSTDNSWQTFILPFSAGMWVGV-LLSLFVVG-TVFYAISFLNAIINGNVSSEFFRCLRP 406
            :.:...|:...|...|:.|:|..:||.: ::.|.||. |||.              .|||..:..
Zfish   583 SVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLSVVAVTVFI--------------FEFFSPVGY 633

  Fly   407 NRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP-RMPRNWPL 470
            ||:: ...|......|.|..|                     |.|.::::...::| ..||....
Zfish   634 NRSL-QSGKTAGGSKFTIGKS---------------------IWLLWALVFNNSVPVENPRGTTS 676

  Fly   471 RVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLRSH----IPP------STGATE- 524
            :::...:..:.::.:|:|.|:..|.:.......|:..|.|....|    .||      ..|:||
Zfish   677 KIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGSTEE 741

  Fly   525 -------NRQFFLEANDEVARKVGEKMEVFGYSDDLTSRIAKGQC-AYYDNEFYLRYLRVADESG 581
                   |...::..|::  |.|          :|....:..|:. |:..:...|.|:...||..
Zfish   742 NIRSNYPNMHQYMVRNNQ--RGV----------EDAIENLKTGKLDAFIYDAAVLNYMARKDEGC 794

  Fly   582 SALHIMKECVLYMP-VVLAMEKNSALKPRVDASIQHLA---EGGLIAK-WLKDAIEHLPAEALAQ 641
            ..:.|....|.... ..:|:.|||..|..:|.::..|.   |..::.: ||.....:...|.::.
Zfish   795 KVMTIGSGKVFATTGYGVALHKNSRWKRPLDLALLQLVGDDEIDMLERLWLSGICHNDKIEVMSS 859

  Fly   642 QEALMNIQKFWSSFVALLIGYVISMLTLLAER---WHFKH 678
            :   ::|......|..||:...:|:|....|.   |..:|
Zfish   860 K---LDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWKLRH 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	46/256 (18%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	89/445 (20%)
		HisJ	<507..>590	CDD:223904	20/108 (19%)
		Lig_chan	605..877	CDD:278489	63/322 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830