DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grid2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	535	Identity:	109/535 - (20%)
Similarity:	190/535 - (35%)	Gaps:	147/535 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 MKNIANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWA----NATKSFQGVEVEIMNA 254
            :..:|.|:...||||.:......:|:.|..|.|......|.|:.:    ...|.:||..:::::|
Zfish   413 VSRLATWDPIHGLNGTLTDRKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDA 477

  Fly   255 LGKALNFK-PVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFA 318
            |...|.|| .:|..|:.               .|||...|| ..||      |:.|:....|...
Zfish   478 LANYLGFKYEIYVAPDH---------------KYGSQQADG-TWNG------LIGELVFKRADVG 520

  Fly   319 IGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFY 383
            :..|.:......:|:.:..:....:..|..::.........:.||...:|..:..::.:|||:.|
Zfish   521 LSALTITPERESVVDFTTRYMDYSVGVLLRKAERTVDMFACLAPFDLSLWACIAGTVLLVGTLVY 585

  Fly   384 AISFLN--AIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRS--SKGDRMPRDLFDG 444
            .:::||  .:..|:|||               ..:|..:.|     .|.|  .:|..:|
Zfish   586 LLNWLNPPRLPMGSVSS---------------TTLYNSMWF-----VYGSFVQQGGEVP------ 624

  Fly   445 YTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLE 509
            ||.  |.|                  |::.|.:|::.::::::|.|:..|.|.......:|.:|:
Zfish   625 YTT--LAT------------------RMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQ 669

  Fly   510 DLLRSHIPP-----------------------------------STGATENRQFFLEANDEVARK 539
            ||.:....|                                   .||..||.   :|.:.|..||
Zfish   670 DLAKQTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGAENN---VEESKEGIRK 731

  Fly   540 VGEKMEVFGYSDDLTSRIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNS 604
            |                 ..|:.|:..:...|.|:.:.||..| |:.:...|......:||:..|
Zfish   732 V-----------------KYGRFAFVWDAAVLEYVAINDEDCS-LYTVSNNVADRGYGMAMQHGS 778

  Fly   605 ALKPRVDASIQHLAEGG----LIAKWL-KDAIEHLPAEALA-----QQEALMNIQKFWSSFVALL 659
            ..:......|..|.:.|    |..||. :|:    |.:..:     :..:.::|..|...|..|.
Zfish   779 PYRDIFSQRILELQQNGDMDILKLKWWPRDS----PCDLYSPVGTRKSGSALDIHSFAGVFFVLA 839

  Fly   660 IGYVISMLTLLAERW 674
            .|.|:|.|....|.|
Zfish   840 AGVVLSCLIATVETW 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	53/278 (19%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	4/13 (31%)
		ANF_receptor	42..404	CDD:279440
		PBP2_iGluR_delta_2	440..806	CDD:270449	90/454 (20%)
		Lig_chan	568..841	CDD:278489	66/343 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740