DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and gria1b

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	790	Identity:	159/790 - (20%)
Similarity:	271/790 - (34%)	Gaps:	240/790 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VIPFFVMRTNESDDLQ-RPSRQVEL--FVKAIK--------SSDCELNVI-TILN-----GWQV- 124
            |.|.|.:.||....:| ||..|..|  .|:..|        |||..|.|: .||:     .|||
Zfish   108 VTPSFPIDTNNQFVIQLRPELQDALIALVEHYKWNKFVYMYSSDSGLTVLQKILDTAAEKTWQVT 172

  Fly   125 ---------QRFLGYIYD------------------NRSLNM---QKK------FVLLH----DL 149
                     ..||..|.|                  |..||:   |||      ::|.:    ||
Zfish   173 SINFDTLTEAAFLKAIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYHYILANLGFLDL 237

  Fly   150 RLFE---------------------SDMIHLWSVFIDAIFL---KRQLDNKYTISTIAFPGILSG 190
            .|.|                     |..|..|..| |:..|   ||:|  ||| ..:.:.|:...
Zfish   238 NLTEFRKGGANVTGFQLMNYTNPTVSRTIQDWLEF-DSKDLKSPKRRL--KYT-GALTYDGVTVM 298

  Fly   191 VLVMKNI---------------------ANWELG------------KGLNGRILFADK--TSNL- 219
            ....:|:                     |.|..|            :||.|.:.|.||  .:|.
Zfish   299 ATAFQNLRKQRIDISRRGNAGECLANPPAPWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFT 363

  Fly   220 -----FGTSLPVAI------SEHVPMVLWAN---------------------------------- 239
                 ||.|.|..:      .::|....::|
Zfish   364 VSVMEFGPSGPKKVGYWNQREKYVSTATYSNMLNETFGLQNRTYVVTTILEAPYVMLKKNHEQLV 428

  Fly   240 ATKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDS 304
            ....::|..||:...:.|.:.:.   |:         .||.|...  ||:.:.:....||
Zfish   429 GNDKYEGYCVELAAEIAKHVGYS---YR---------LELVGDGK--YGARDAETMMWNG----- 474

  Fly   305 MLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFL--TPESSTDNSWQTFILPFSAGM 367
             :|.|:....|..|:..|.:..|..::::.|.|.....::.:  .|..|....: :|:.|.:..:
Zfish   475 -MVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVF-SFLDPLAYEI 537

  Fly   368 WVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSS 432
            |:.::.:...|..|.:.:|..:. ...:...|.....:.|:|.|..|:..:..:   .....|..
Zfish   538 WMCIVFAYIGVSVVLFLVSRFSP-YEWHADDEEETADQQNQNQPPSPEPNQSPN---QSQNQREE 598

  Fly   433 KGDRMPRDLFD-GYTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAIL 496
            |.::.|....: |..|.:..:....:.......||:...|::.|.:|.:.::::::|.|:..|.|
Zfish   599 KQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 663

  Fly   497 ANPAARVTIDTLEDLLR-SHIPPST---GATENRQFFLEANDEVARKVGEKME-----VFGYSDD 552
            ........|::.|||.: :.|...|   |:|  ::||..:...|..|:...|:     ||..:.|
Zfish   664 TVERMVSPIESAEDLAKQTEIAYGTLDGGST--KEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTD 726

  Fly   553 ---LTSRIAKGQCAYYDNEFYLRYLRV------------ADESGSALHIMKECVLYMPVVLAMEK 602
               :..|.:||:.||........|:..            .|..|..              :|..|
Zfish   727 EGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG--------------VATPK 777

  Fly   603 NSALKPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQE-ALMNIQKFWSSFVALLIGY 662
            .|||:..|:.::..|.|.||:    .||..|..|.......::.: :.:::......|..|:.|.
Zfish   778 GSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGL 842

  Fly   663 VISMLTLLAE 672
            .::||..|.|
Zfish   843 GLAMLVALVE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	54/261 (21%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	65/282 (23%)
		ANF_receptor	41..368	CDD:279440	61/263 (23%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	84/448 (19%)
		Lig_chan	536..842	CDD:278489	63/325 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740