Protein Alignment Ir68a and gria3b

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_938174.1
• Gene: gria3b / 368416
• ZFINID: ZDB-GENE-030616-53
• Length: 883
• Species: Danio rerio
• Alignment Length: 813
• Identity: 138/813 - (16%)
• Similarity: 279/813 - (34%)
• Gaps: 235/813 - (28%)

  Fly     7 LIVAFI--SLAMATSIPIPIANPAPLSGYEMQL--KILLQKILWVANVKRCFAVITDDLHYPIYD 67
            |..:|:  |..:.:.:...|....||.|..:.|  .....|.:::.:..|.|:::...:...:.:
Zfish   110 LHTSFVTPSYPIDSDVQFVIQMRPPLKGAVLSLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVAN 174

  Fly    68 --RIFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQV-----Q 125
              ::...|||....|....|..|..|.::..|.:         .|||::.|.::....|     .
Zfish   175 NWQVTARSVGSITDPQEFRRIIEEMDRRQEKRYL---------IDCEVDRINVILEQVVTLGKNS 230

  Fly   126 RFLGYIYDN---RSLNMQKKFV---------LLHDLRLFESDMIHLWSVFIDAIFLK-RQLDNKY 177
            |...||..|   .::::.|.|:         :::...|.....:..|....:..|.: :....||
Zfish   231 RGYHYIIANLGFTNISLDKVFLGGANISGFQIINPENLVVQQFLQRWDRLDEREFPEAKNTPLKY 295

  Fly   178 TISTIAFPGIL---------------------SGVLVMKNIANWELG------------KGLNGR 209
            | |.:::..||                     :|..:......|..|            :|:.|.
Zfish   296 T-SALSYDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGN 359

  Fly   210 I-----------------------------------------LFADKTSNLFGTSLPVAISEHVP 233
            |                                         .|.:.:|::...::.|......|
Zfish   360 IQFDSFGRRTNYTIDVYEMKTGGPRKIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAP 424

  Fly   234 MVLW------ANATKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNP 292
            .|::      ....:.::|..|::.:.:.|.:..|   |:.:       ..:||    .||:.:|
Zfish   425 YVMYKKNHMHLEGNEKYEGYCVDLASEIAKHVGIK---YRLS-------IVMDG----KYGARDP 475

  Fly   293 DGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFL--TPESSTDNS 355
            :..:.||      :|.|:....|..|:..|.:..|..::::.|.|.....::.:  .|:.|....
Zfish   476 ETKSWNG------MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 534

  Fly   356 WQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRP------------NR 408
            : :|:.|.:..:|:.::.:...|..|.:.:|..:                |            :.
Zfish   535 F-SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS----------------PYEWQLDETDEVKDP 582

  Fly   409 NVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALPRMPRNWPLRVL 473
            ..|.||                       |.|.  |..|.:..:....:.......||:...|::
Zfish   583 QTPPDP-----------------------PNDF--GIFNSLWFSLGAFMQQGCDISPRSLSGRIV 622

  Fly   474 TGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR-SHIPPST---GATENRQFFLEAND 534
            .|.:|.:.::::::|.|:..|.|........|::.|||.: :.|...|   |:|  ::||..:..
Zfish   623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGST--KEFFRRSKI 685

  Fly   535 EVARKVGEKME-----VFG-YSDDLTSRI--AKGQCAYYDNEFYLRYLRV------------ADE 579
            .|..|:...|:     ||. .:.|..:|:  :||:.|:........|:..            .|.
Zfish   686 AVYEKMWSYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDS 750

  Fly   580 SGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALA 640
            .|..              :|..|.|||:..|:.::..|.|.||:    .||..|..|.......:
Zfish   751 KGYG--------------VATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDS 801

  Fly   641 QQE-ALMNIQKFWSSFVALLIGYVISMLTLLAE 672
            :.: :.:::......|..|:.|..::|:..|.|
Zfish   802 KDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	60/334 (18%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_type1	25..398	CDD:471960	45/297 (15%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	84/459 (18%)