DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and gria3b

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	813	Identity:	138/813 - (16%)
Similarity:	279/813 - (34%)	Gaps:	235/813 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIVAFI--SLAMATSIPIPIANPAPLSGYEMQL--KILLQKILWVANVKRCFAVITDDLHYPIYD 67
            |..:|:  |..:.:.:...|....||.|..:.|  .....|.:::.:..|.|:::...:...:.:
Zfish   110 LHTSFVTPSYPIDSDVQFVIQMRPPLKGAVLSLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVAN 174

  Fly    68 --RIFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQV-----Q 125
              ::...|||....|....|..|..|.::..|.:         .|||::.|.::....|     .
Zfish   175 NWQVTARSVGSITDPQEFRRIIEEMDRRQEKRYL---------IDCEVDRINVILEQVVTLGKNS 230

  Fly   126 RFLGYIYDN---RSLNMQKKFV---------LLHDLRLFESDMIHLWSVFIDAIFLK-RQLDNKY 177
            |...||..|   .::::.|.|:         :::...|.....:..|....:..|.: :....||
Zfish   231 RGYHYIIANLGFTNISLDKVFLGGANISGFQIINPENLVVQQFLQRWDRLDEREFPEAKNTPLKY 295

  Fly   178 TISTIAFPGIL---------------------SGVLVMKNIANWELG------------KGLNGR 209
            | |.:::..||                     :|..:......|..|            :|:.|.
Zfish   296 T-SALSYDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGN 359

  Fly   210 I-----------------------------------------LFADKTSNLFGTSLPVAISEHVP 233
            |                                         .|.:.:|::...::.|......|
Zfish   360 IQFDSFGRRTNYTIDVYEMKTGGPRKIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAP 424

  Fly   234 MVLW------ANATKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNP 292
            .|::      ....:.::|..|::.:.:.|.:..|   |:.:       ..:||    .||:.:|
Zfish   425 YVMYKKNHMHLEGNEKYEGYCVDLASEIAKHVGIK---YRLS-------IVMDG----KYGARDP 475

  Fly   293 DGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFL--TPESSTDNS 355
            :..:.||      :|.|:....|..|:..|.:..|..::::.|.|.....::.:  .|:.|....
Zfish   476 ETKSWNG------MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 534

  Fly   356 WQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRP------------NR 408
            : :|:.|.:..:|:.::.:...|..|.:.:|..:                |            :.
Zfish   535 F-SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS----------------PYEWQLDETDEVKDP 582

  Fly   409 NVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALPRMPRNWPLRVL 473
            ..|.||                       |.|.  |..|.:..:....:.......||:...|::
Zfish   583 QTPPDP-----------------------PNDF--GIFNSLWFSLGAFMQQGCDISPRSLSGRIV 622

  Fly   474 TGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR-SHIPPST---GATENRQFFLEAND 534
            .|.:|.:.::::::|.|:..|.|........|::.|||.: :.|...|   |:|  ::||..:..
Zfish   623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGST--KEFFRRSKI 685

  Fly   535 EVARKVGEKME-----VFG-YSDDLTSRI--AKGQCAYYDNEFYLRYLRV------------ADE 579
            .|..|:...|:     ||. .:.|..:|:  :||:.|:........|:..            .|.
Zfish   686 AVYEKMWSYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDS 750

  Fly   580 SGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALA 640
            .|..              :|..|.|||:..|:.::..|.|.||:    .||..|..|.......:
Zfish   751 KGYG--------------VATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDS 801

  Fly   641 QQE-ALMNIQKFWSSFVALLIGYVISMLTLLAE 672
            :.: :.:::......|..|:.|..::|:..|.|
Zfish   802 KDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	52/260 (20%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	45/295 (15%)
		ANF_receptor	36..379	CDD:279440	45/278 (16%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	84/459 (18%)
		Lig_chan	544..824	CDD:278489	60/336 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740