DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and Grik3

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	112/536 - (20%)
Similarity:	193/536 - (36%)	Gaps:	152/536 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 MKNIANWELGKGLN------GRILFADKTSNLFGTSLPVAISEHVPMVLWANATKS------FQG 246
            ::.:..|....|||      ||  ..:.|.:|...||.|......|.|::..:.::      |:|
  Rat   402 LEKVGVWSPADGLNITEVAKGR--GPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEG 464

  Fly   247 VEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVA 311
            ..::::..|...|.|.   |:....|       ||    .||:.:..| ..||      :|.|:.
  Rat   465 YCIDLLKELAHILGFS---YEIRLVE-------DG----KYGAQDDKG-QWNG------MVKELI 508

  Fly   312 AHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMW 368
            .|.|..|:..|.:..|..|.::.|.|       |:|        ..:.|:.|..:|:.|.|..:|
  Rat   509 DHKADLAVAPLTITHVREKAIDFSKP-------FMTLGVSILYRKPNGTNPSVFSFLNPLSPDIW 566

  Fly   369 VGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSK 433
            :.|||:...|..|.:.|:                                |.|
  Rat   567 MYVLLAYLGVSCVLFVIA--------------------------------RFS------------ 587

  Fly   434 GDRMPRDLFDGY----------TNCILLT---YSM--LLYVALPRMPRNWPLRVLTGWYWIYCIL 483
                |.:.:|.:          .|..||.   :.|  |:......||:....|::.|.:|.:.::
  Rat   588 ----PYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLI 648

  Fly   484 LVATYRASFTAILANPAARVTIDTLEDLLR----SHIPPSTGATENRQFFLEANDEVARKVGEKM 544
            ::::|.|:..|.|........||:.:||.:    .:.....|||  ..||.::      |:....
  Rat   649 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGAT--MTFFKKS------KISTFE 705

  Fly   545 EVFGYSDDLTSRIAKGQCAYYDNEFYLRYLRVAD-----ESGSALHI-MKECVLYMPVVLAMEK- 602
            :::.:.....|.:.|      :||..::....||     ||.:..:| .:.|.|.....|...|
  Rat   706 KMWAFMSSKPSALVK------NNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKG 764

  Fly   603 -------NSALKPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFV 656
                   .|..:.::..:|..|.|...:    .||.:.:  ..|.|...:..|| .|||....|:
  Rat   765 YGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGS--GCPEEENKEASAL-GIQKIGGIFI 826

  Fly   657 ALLIGYVISMLTLLAE 672
            .|..|.|:|:|..:.|
  Rat   827 VLAAGLVLSVLVAVGE 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	54/268 (20%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	4/14 (29%)
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	90/457 (20%)
		Lig_chan	564..832	CDD:278489	63/332 (19%)
		Glutamate binding	690..692		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740