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Protein Alignment Ir68a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	676	Identity:	127/676 - (18%)
Similarity:	234/676 - (34%)	Gaps:	183/676 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 FFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQ-VQRFLGYI----YDNRSLNMQ 140
            |.|......|||   :|:|            ...|..:..|.| :.|..|::    :|.|:.|
Human   305 FAVRSAGWRDDL---ARRV------------AAGVAVVARGAQALLRDYGFLPELGHDCRAQN-- 352

  Fly   141 KKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNK-YTISTIAF---PGILSGVLVMKNIANWE 201
                     |....:.:|.:       |:....||: |:.:...|   |.::  |:.:.....||
Human   353 ---------RTHRGESLHRY-------FMNITWDNRDYSFNEDGFLVNPSLV--VISLTRDRTWE 399

  Fly   202 LGKGLN--------------GRILF-ADKTSNLFGTSL------------PVA---ISEHVPMVL 236
            :.....              ||.|. .|.|.:|...:|            |::   |.:.||...
Human   400 VVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRS 464

  Fly   237 WANATKS------------FQGVEVEIMNALGKALNFK-PVYYKPNQTENMDWTELDGGASVAYG 288
            ..|.|.|            .:|..::|:..|...:.|. .:|...|
Human   465 QLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTN------------------- 510

  Fly   289 SGNPDGYAQNGTHIDSM---LVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPES 350
                   .::|..||.:   ::.||....|..|||.|.:.:...::|:.|.|.....::.:...|
Human   511 -------GKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARS 568

  Fly   351 STDNSWQTFILPFSAGMWVGV-LLSLFVVGTVFYAISFLNAI-INGNVSSEFFRCLRPNRNVPMD 413
            :...|...|:.|:|..:||.: ::.|.||....:...:|:.: .|.::::.    .||..:
Human   569 NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATG----KRPGGS---- 625

  Fly   414 PKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP-RMPRNWPLRVLTGWY 477
                   :|.|..|                     |.|.::::...::| ..||....:::...:
Human   626 -------TFTIGKS---------------------IWLLWALVFNNSVPVENPRGTTSKIMVLVW 662

  Fly   478 WIYCILLVATYRASFTAILANPAARVTIDTLEDLL----RSHIPP------STGATEN--RQFFL 530
            ..:.::.:|:|.|:..|.:.......|:..|.|..    :...||      ..|:||.  |..:.
Human   663 AFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYP 727

  Fly   531 EANDEVARKVGEKMEVFGYSDDLTSRIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMP 595
            :.:..:.|....::|     :.||...|....|:..:...|.|:...||....:.|....|....
Human   728 DMHSYMVRYNQPRVE-----EALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATT 787

  Fly   596 -VVLAMEKNSALKPRVD-ASIQHLAEGG---LIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSF 655
             ..:|:.|.|..|..:| |.:|.|.:..   |...||.....:...|.::.:   ::|......|
Human   788 GYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSK---LDIDNMAGVF 849

  Fly   656 VALLIGYVISMLTLLAER---WHFKH 678
            ..||:...:|:|....|.   |..:|
Human   850 YMLLVAMGLSLLVFAWEHLVYWRLRH 875

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.