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Protein Alignment Ir68a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	761	Identity:	149/761 - (19%)
Similarity:	257/761 - (33%)	Gaps:	222/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIVAFISLAMATSIPIPIANPAPLSGYEMQLKILLQKILWVANVKRCFAVITDDL--HYPI---- 65
            :|:.:.:...||.| ..:||...|:||         ...|:  |....|..||.:  .:|.
Human   227 IILLYCTKEEATYI-FEVANSVGLTGY---------GYTWI--VPSLVAGDTDTVPAEFPTGLIS 279

  Fly    66 --YDRIFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQVQRFL 128
              ||...:....|......::.|..||.|...|     |:...||| |
Human   280 VSYDEWDYGLPARVRDGIAIITTAASDMLSEHS-----FIPEPKSS-C----------------- 321

  Fly   129 GYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQL---DNKYTISTIAFPGILSG 190
               |:.            |:.|:::|:|::.:  .|:..|..|.|   ::.|.:    .|.::
Human   322 ---YNT------------HEKRIYQSNMLNRY--LINVTFEGRNLSFSEDGYQM----HPKLV-- 363

  Fly   191 VLVMKNIANWE-LGKGLNGRILFADK---------------TSNLFGTSLPVAISEHVPMVL--- 236
            ::::.....|| :||       :.||               |.......|.:...|..|.|:
Human   364 IILLNKERKWERVGK-------WKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421

  Fly   237 --------------------WANAT--------KSFQGVEVEIMNALGKALNFKPVYY-----KP 268
                                ..|.|        |..:|..::|:..:.|::.|....|     |.
Human   422 VDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKH 486

  Fly   269 NQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVE 333
            .:..|..|                     ||      ::.||....|..|:|.|.:.:...::|:
Human   487 GKKINGTW---------------------NG------MIGEVVMKRAYMAVGSLTINEERSEVVD 524

  Fly   334 LSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTV-FYAISFLNAIINGNVS 397
            .|.|.....::.:...|:...|...|:.||||.:||.:.:.|.:|..| .:...:.:.:
Human   525 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV------ 583

  Fly   398 SEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP 462
             .:.|||...|. |..|      ||.|.                     ..|.|.:.::...::|
Human   584 -GYNRCLADGRE-PGGP------SFTIG---------------------KAIWLLWGLVFNNSVP 619

  Fly   463 -RMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLL----RSHIPP---- 518
             :.|:....:::...:..:.::.:|:|.|:..|.:........:..|.|..    ....||
Human   620 VQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFG 684

  Fly   519 --STGATEN--RQFFLEANDEVARKVGEKMEVFGYSDDLTS-RIAKGQCAYYDNEFYLRYLRVAD 578
              ..|:||.  |..:.|.:..:.     |....|..|.|.| :..|.....|| ...|.|:...|
Human   685 TVPNGSTERNIRNNYAEMHAYMG-----KFNQRGVDDALLSLKTGKLDAFIYD-AAVLNYMAGRD 743

  Fly   579 ESGSALHIMKECVLYMP-VVLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAEA 638
            |....:.|....|.... ..:|::|:|..|.:||.:|..|...|    |.|.||.....:...|.
Human   744 EGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEV 808

  Fly   639 LAQQEALMNIQKFWSSFVALLIGYVISMLTLLAER---WHFKHIVM 681
            ::.|   ::|......|..|.....:|::|.:.|.   |.|:|..|
Human   809 MSSQ---LDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFM 851

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.