Protein Alignment Ir68a and GRIK4

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 149/736 - (20%)
• Similarity: 274/736 - (37%)
• Gaps: 182/736 - (24%)

  Fly     8 IVAFISLAMATSIPIPIANPAPLSGYE----MQLKILLQKILWVANVKRCFAVITDD----LHYP 64
            |:...:.:|:.:|.:..|....:|.|.    ..|:..||::          ..:.||    |.:.
Human   215 IIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRM----------DSLVDDRVNILGFS 269

  Fly    65 IYDR--IFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSS---DCELNVITILNGWQV 124
            |:::  .||:.        |....|:|  .|.....|.....|:.|:   |....|:|     .|
Human   270 IFNQSHAFFQE--------FAQSLNQS--WQENCDHVPFTGPALSSALLFDAVYAVVT-----AV 319

  Fly   125 QRFLGYIYDNRSLNMQKKFVLLHDLRLFE---SDMIHLWSVFIDAI-----FLKRQLDNKYTIST 181
            |..      |||..:..|.:.....::::   |.|.:|..|.::.:     |..:...:.|.:..
Human   320 QEL------NRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKI 378

  Fly   182 IAFPGILSGVLVMKNIANWELGKGLN-GRILFADKTSN-LFGTSLPV-AISEHVPMVLWAN---- 239
            :.|  ..:|   .:.|..|.:.:||: ...|:|...|: ||.|:|.| .|.|:..::|..|
Human   379 LQF--TRNG---FRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEM 438

  Fly   240 -ATKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHID 303
             ....::|..|:::..|.:.|.|.   ||         ..|.|..  .||.  |:.   |||.
Human   439 EGNDRYEGFCVDMLKELAEILRFN---YK---------IRLVGDG--VYGV--PEA---NGTW-- 482

  Fly   304 SMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFI 360
            :.:|.|:.|..|..|:..|.:.....|:::.|.|       |:|        ........:.:|:
Human   483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKP-------FMTLGISILYRVHMGRKPGYFSFL 540

  Fly   361 LPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIA 425
            .|||.|:|:.:||:...|..|.:.::.|...       |::
Human   541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPY-------EWY------------------------ 574

  Fly   426 ISRYRSSKGDRMPRDLFDGYTNCILLTYSM----------LLYVALPRMPRNWPLRVLTGWYWIY 480
                       .|.....|..|.::..||:          .:.......||....|.::|.:|.:
Human   575 -----------SPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAF 628

  Fly   481 CILLVATYRASFTAILANPAARVTIDTLEDLL-RSHIPPST--GATENRQFFLEANDEVARKVGE 542
            .::::::|.|:..|.|......|.|::::||. ::.|...|  |.: :..||..:..:..:::..
Human   629 TLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGS-SMTFFQNSRYQTYQRMWN 692

  Fly   543 KM-----EVFGYS-DDLTSRIAKGQCAYY----DNEFYLRYLRVADESGSALHIMKECVLYMPVV 597
            .|     .||..| ::..:|:.....|:.    .||:|.:......:.|..|. .|...:.|||
Human   693 YMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLD-TKGYGIGMPV- 755

  Fly   598 LAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVAL 658
                 .|..:...|.:|..|.|..    |..||.:..  ..|.|...:.:.| .::.....||.|
Human   756 -----GSVFRDEFDLAILQLQENNRLEILKRKWWEGG--KCPKEEDHRAKGL-GMENIGGIFVVL 812

  Fly   659 LIGYVISM-LTLLAERWHFKH 678
            :.|.:::: :.:|...|..:|
Human   813 ICGLIVAIFMAMLEFLWTLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	59/320 (18%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	43/222 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	91/447 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956