DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and GRIK4

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	736	Identity:	149/736 - (20%)
Similarity:	274/736 - (37%)	Gaps:	182/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IVAFISLAMATSIPIPIANPAPLSGYE----MQLKILLQKILWVANVKRCFAVITDD----LHYP 64
            |:...:.:|:.:|.:..|....:|.|.    ..|:..||::          ..:.||    |.:.
Human   215 IIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRM----------DSLVDDRVNILGFS 269

  Fly    65 IYDR--IFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSS---DCELNVITILNGWQV 124
            |:::  .||:.        |....|:|  .|.....|.....|:.|:   |....|:|     .|
Human   270 IFNQSHAFFQE--------FAQSLNQS--WQENCDHVPFTGPALSSALLFDAVYAVVT-----AV 319

  Fly   125 QRFLGYIYDNRSLNMQKKFVLLHDLRLFE---SDMIHLWSVFIDAI-----FLKRQLDNKYTIST 181
            |..      |||..:..|.:.....::::   |.|.:|..|.::.:     |..:...:.|.:..
Human   320 QEL------NRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKI 378

  Fly   182 IAFPGILSGVLVMKNIANWELGKGLN-GRILFADKTSN-LFGTSLPV-AISEHVPMVLWAN---- 239
            :.|  ..:|   .:.|..|.:.:||: ...|:|...|: ||.|:|.| .|.|:..::|..|
Human   379 LQF--TRNG---FRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEM 438

  Fly   240 -ATKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHID 303
             ....::|..|:::..|.:.|.|.   ||         ..|.|..  .||.  |:.   |||.
Human   439 EGNDRYEGFCVDMLKELAEILRFN---YK---------IRLVGDG--VYGV--PEA---NGTW-- 482

  Fly   304 SMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFI 360
            :.:|.|:.|..|..|:..|.:.....|:::.|.|       |:|        ........:.:|:
Human   483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKP-------FMTLGISILYRVHMGRKPGYFSFL 540

  Fly   361 LPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIA 425
            .|||.|:|:.:||:...|..|.:.::.|...       |::
Human   541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPY-------EWY------------------------ 574

  Fly   426 ISRYRSSKGDRMPRDLFDGYTNCILLTYSM----------LLYVALPRMPRNWPLRVLTGWYWIY 480
                       .|.....|..|.::..||:          .:.......||....|.::|.:|.:
Human   575 -----------SPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAF 628

  Fly   481 CILLVATYRASFTAILANPAARVTIDTLEDLL-RSHIPPST--GATENRQFFLEANDEVARKVGE 542
            .::::::|.|:..|.|......|.|::::||. ::.|...|  |.: :..||..:..:..:::..
Human   629 TLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGS-SMTFFQNSRYQTYQRMWN 692

  Fly   543 KM-----EVFGYS-DDLTSRIAKGQCAYY----DNEFYLRYLRVADESGSALHIMKECVLYMPVV 597
            .|     .||..| ::..:|:.....|:.    .||:|.:......:.|..|. .|...:.|||
Human   693 YMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLD-TKGYGIGMPV- 755

  Fly   598 LAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVAL 658
                 .|..:...|.:|..|.|..    |..||.:..  ..|.|...:.:.| .::.....||.|
Human   756 -----GSVFRDEFDLAILQLQENNRLEILKRKWWEGG--KCPKEEDHRAKGL-GMENIGGIFVVL 812

  Fly   659 LIGYVISM-LTLLAERWHFKH 678
            :.|.:::: :.:|...|..:|
Human   813 ICGLIVAIFMAMLEFLWTLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	52/258 (20%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	43/220 (20%)
		ANF_receptor	43..382	CDD:279440	38/199 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	91/447 (20%)
		Lig_chan	547..816	CDD:278489	59/321 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740