Protein Alignment Ir68a and GRIK3

DIOPT Version :9

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 133/663 - (20%)
• Similarity: 228/663 - (34%)
• Gaps: 215/663 - (32%)

  Fly   114 NVITILNGWQVQRFLGYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYT 178
            :|..|:..|.::|...   ..||.:.....|::.|..|. .|.:|:.||..       |...:.|
Human   291 HVSAIVEKWSMERLQA---APRSESGLLDGVMMTDAALL-YDAVHIVSVCY-------QRAPQMT 344

  Fly   179 ISTI--------AFPGILSGVLVMKNIANWELGKGLNGRILFADKTS------------------ 217
            ::::        .|.|.....:   ..|.||   ||.|||:| :|||
Human   345 VNSLQCHRHKAWRFGGRFMNFI---KEAQWE---GLTGRIVF-NKTSGLRTDFDLDIISLKEDGL 402

  Fly   218 ---------------------------NLFGTSLPVAISEHVPMVLWANATKS------FQGVEV 249
                                       :|...||.|......|.|::..:.::      |:|..:
Human   403 EKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCI 467

  Fly   250 EIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHS 314
            :::..|...|.|.   |:....|       ||    .||:.:..| ..||      :|.|:..|.
Human   468 DLLKELAHILGFS---YEIRLVE-------DG----KYGAQDDKG-QWNG------MVKELIDHK 511

  Fly   315 ARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMWVGV 371
            |..|:..|.:..|..|.::.|.|       |:|        ..:.|:.|..:|:.|.|..:|:.|
Human   512 ADLAVAPLTITHVREKAIDFSKP-------FMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYV 569

  Fly   372 LLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDR 436
            ||:...|..|.:.|:                                |.|
Human   570 LLAYLGVSCVLFVIA--------------------------------RFS--------------- 587

  Fly   437 MPRDLFDGY----------TNCILLT---YSM--LLYVALPRMPRNWPLRVLTGWYWIYCILLVA 486
             |.:.:|.:          .|..||.   :.|  |:......||:....|::.|.:|.:.:::::
Human   588 -PYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS 651

  Fly   487 TYRASFTAILANPAARVTIDTLEDLLR----SHIPPSTGATENRQFFLEANDEVARKVGEKMEVF 547
            :|.|:..|.|........||:.:||.:    .:.....|||  ..||.::      |:....:::
Human   652 SYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGAT--MTFFKKS------KISTFEKMW 708

  Fly   548 GYSDDLTSRIAKGQCAYYDNEFYLRYLRVAD-----ESGSALHI-MKECVLYMPVVLAMEK---- 602
            .:.....|.:.|      :||..::....||     ||.:..:: .:.|.|.....|...|
Human   709 AFMSSKPSALVK------NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGI 767

  Fly   603 ----NSALKPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALL 659
                .|..:.::..:|..|.|...:    .||.:.:  ..|.|...:..|| .|||....|:.|.
Human   768 GTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGS--GCPEEENKEASAL-GIQKIGGIFIVLA 829

  Fly   660 IGYVISMLTLLAE 672
            .|.|:|:|..:.|
Human   830 AGLVLSVLVAVGE 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	53/268 (20%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	29/143 (20%)
		ANF_receptor	55..398	CDD:279440	29/124 (23%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	89/457 (19%)
		Lig_chan	564..832	CDD:278489	62/332 (19%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740