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Protein Alignment Ir68a and GRIK2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	654	Identity:	129/654 - (19%)
Similarity:	229/654 - (35%)	Gaps:	181/654 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IYDRIFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQVQRFLG 129
            :||.:...||..:..|...:.:.:. :..:|.|....|:..||.:.           |  :...|
Human   323 MYDAVHVVSVAVQQFPQMTVSSLQC-NRHKPWRFGTRFMSLIKEAH-----------W--EGLTG 373

  Fly   130 YIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVM 194
            .|..|::..::..|.|                   |.|.||.:                    .:
Human   374 RITFNKTNGLRTDFDL-------------------DVISLKEE--------------------GL 399

  Fly   195 KNIANWELGKGLN------GRILFADKTSNLFGTSLPVAISEHVPMVLWANATK------SFQGV 247
            :.|..|:...|||      |:.  |:.|.:|...||.|......|.||:..:.|      .|:|.
Human   400 EKIGTWDPASGLNMTESQKGKP--ANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGY 462

  Fly   248 EVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAA 312
            .::::..|...|.|.   |:....|       ||    .||:.:......||      :|.|:..
Human   463 CIDLLRELSTILGFT---YEIRLVE-------DG----KYGAQDDANGQWNG------MVRELID 507

  Fly   313 HSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMWV 369
            |.|..|:..|.:..|..|:::.|.|       |:|        ..:.|:....:|:.|.|..:|:
Human   508 HKADLAVAPLAITYVREKVIDFSKP-------FMTLGISILYRKPNGTNPGVFSFLNPLSPDIWM 565

  Fly   370 GVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKG 434
            .:||:...|..|.:.|:..:.          :....|:   |.:|
Human   566 YILLAYLGVSCVLFVIARFSP----------YEWYNPH---PCNP-------------------- 597

  Fly   435 DRMPRDLFD-GYT--NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAIL 496
               ..|:.: .:|  |........|:......||:....|::.|.:|.:.::::::|.|:..|.|
Human   598 ---DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFL 659

  Fly   497 ANPAARVTIDTLEDLLRSHIPPSTGATEN---RQFFLEANDEVARKVG--EKMEVFGYSDDLTSR 556
            ........||:.:||.: ......||.|:   ..||.::      |:.  :||..|     ::||
Human   660 TVERMESPIDSADDLAK-QTKIEYGAVEDGATMTFFKKS------KISTYDKMWAF-----MSSR 712

  Fly   557 IAKGQCAYYDNEFYLRYLRVAD-----ESGSALHI-MKECVLYMPVVLAMEK--------NSALK 607
              :.......||..::.:..:|     ||.:...: .:.|.|.....|...|        .|..:
Human   713 --RQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYR 775

  Fly   608 PRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLT 668
            .::..:|..|.|.|.:    .||.:.  ...|.|...:..|| .:|.....|:.|..|.|:|:..
Human   776 DKITIAILQLQEEGKLHMMKEKWWRG--NGCPEEESKEASAL-GVQNIGGIFIVLAAGLVLSVFV 837

  Fly   669 LLAE 672
            .:.|
Human   838 AVGE 841

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.