Protein Alignment Ir68a and GRIK1

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 130/620 - (20%)
• Similarity: 217/620 - (35%)
• Gaps: 171/620 - (27%)

  Fly   129 GYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVL- 192
            |:|..|::..::|.|.|                   |.|.||.:       .|....|.:|..|
Human   374 GHITFNKTNGLRKDFDL-------------------DIISLKEE-------GTEKAAGEVSKHLY 412

  Fly   193 -VMKNIANWELGKGLNGRILFADKTSN----LFGTSLPVAISEHVPMVLWANATK------SFQG 246
             |.|.|..|....|||......||:||    |...:|.|......|.|::..:.|      .|:|
Human   413 KVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEG 477

  Fly   247 VEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVA 311
            ..::::..|...|.|  :|         |...:..|   .||:.|..| ..||      :|.|:.
Human   478 YCLDLLKELSNILGF--IY---------DVKLVPDG---KYGAQNDKG-EWNG------MVKELI 521

  Fly   312 AHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMW 368
            .|.|..|:..|.:..|..|:::.|.|       |:|        ..:.|:....:|:.|.|..:|
Human   522 DHRADLAVAPLTITYVREKVIDFSKP-------FMTLGISILYRKPNGTNPGVFSFLNPLSPDIW 579

  Fly   369 VGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSK 433
            :.|||:...|..|.:.|:....          :....|:   |.:|
Human   580 MYVLLACLGVSCVLFVIARFTP----------YEWYNPH---PCNP------------------- 612

  Fly   434 GDRMPRDLFD-GYT--NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAI 495
                ..|:.: .:|  |........|:......||:....|::.|.:|.:.::::::|.|:..|.
Human   613 ----DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673

  Fly   496 LANPAARVTIDTLEDLLRSHIPPSTGATEN---RQFFLEANDEVARKVG--EKMEVFGYSDDLTS 555
            |........||:.:||.: ......||..:   ..||.::      |:.  |||..|..|...|:
Human   674 LTVERMESPIDSADDLAK-QTKIEYGAVRDGSTMTFFKKS------KISTYEKMWAFMSSRQQTA 731

  Fly   556 RIAKGQCAYYDNEFYLRYL----RVADESGSALHI-MKECVLYMPVVLAMEK--------NSALK 607
            .:..      .:|...|.|    .:..||.|..:: .:.|.|.....|...|        .|..:
Human   732 LVRN------SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYR 790

  Fly   608 PRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLT 668
            .::..:|..|.|.|.:    .||.:.  ...|.|...:..|| .::.....|:.|..|.|:|:..
Human   791 DKITIAILQLQEEGKLHMMKEKWWRG--NGCPEEDNKEASAL-GVENIGGIFIVLAAGLVLSVFV 852

  Fly   669 LLAE--------------------RWHFKHIVMKH 683
            .:.|                    |::|::.|..|
Human   853 AIGEFIYKSRKNNDIEQKGKSSRIRFYFRNKVRFH 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	61/318 (19%)
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	21/82 (26%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	90/445 (20%)