DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir68a and GRIK1

DIOPT Version :9

Sequence 1:NP_648455.2 Gene:Ir68a / 39269 FlyBaseID:FBgn0036150 Length:704 Species:Drosophila melanogaster
Sequence 2:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens


Alignment Length:621 Identity:130/621 - (20%)
Similarity:218/621 - (35%) Gaps:173/621 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 GYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVL- 192
            |:|..|::..::|.|.|                   |.|.||.:       .|....|.:|..| 
Human   374 GHITFNKTNGLRKDFDL-------------------DIISLKEE-------GTEKAAGEVSKHLY 412

  Fly   193 -VMKNIANWELGKGLNGRILFADKTSN----LFGTSLPVAISEHVPMVLWANATK------SFQG 246
             |.|.|..|....|||......||:||    |...:|.|......|.|::..:.|      .|:|
Human   413 KVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEG 477

  Fly   247 VEVEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVA 311
            ..::::..|...|.|  :|         |...:..|   .||:.|..| ..||      :|.|:.
Human   478 YCLDLLKELSNILGF--IY---------DVKLVPDG---KYGAQNDKG-EWNG------MVKELI 521

  Fly   312 AHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMW 368
            .|.|..|:..|.:..|..|:::.|.|       |:|        ..:.|:....:|:.|.|..:|
Human   522 DHRADLAVAPLTITYVREKVIDFSKP-------FMTLGISILYRKPNGTNPGVFSFLNPLSPDIW 579

  Fly   369 VGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSK 433
            :.|||:...|..|.:.|:....          :....|:   |.:|                   
Human   580 MYVLLACLGVSCVLFVIARFTP----------YEWYNPH---PCNP------------------- 612

  Fly   434 GDRMPRDLFD-GYT--NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAI 495
                ..|:.: .:|  |........|:......||:....|::.|.:|.:.::::::|.|:..|.
Human   613 ----DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673

  Fly   496 LANPAARVTIDTLEDLLR----SHIPPSTGATENRQFFLEANDEVARKVG--EKMEVFGYSDDLT 554
            |........||:.:||.:    .:.....|:|  ..||.::      |:.  |||..|..|...|
Human   674 LTVERMESPIDSADDLAKQTKIEYGAVRDGST--MTFFKKS------KISTYEKMWAFMSSRQQT 730

  Fly   555 SRIAKGQCAYYDNEFYLRYL----RVADESGSALHI-MKECVLYMPVVLAMEK--------NSAL 606
            :.:..      .:|...|.|    .:..||.|..:: .:.|.|.....|...|        .|..
Human   731 ALVRN------SDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPY 789

  Fly   607 KPRVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISML 667
            :.::..:|..|.|.|.:    .||.:.  ...|.|...:..|| .::.....|:.|..|.|:|:.
Human   790 RDKITIAILQLQEEGKLHMMKEKWWRG--NGCPEEDNKEASAL-GVENIGGIFIVLAAGLVLSVF 851

  Fly   668 TLLAE--------------------RWHFKHIVMKH 683
            ..:.|                    |::|::.|..|
Human   852 VAIGEFIYKSRKNNDIEQKGKSSRIRFYFRNKVRFH 887

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir68aNP_648455.2 Lig_chan 429..661 CDD:278489 51/257 (20%)
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 21/81 (26%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 90/446 (20%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)