DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and GRID2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_011530195.2	Gene:	GRID2 / 2895	HGNCID:	4576	Length:	1035	Species:	Homo sapiens

Alignment Length:	512	Identity:	100/512 - (19%)
Similarity:	182/512 - (35%)	Gaps:	113/512 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 WELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWA----NATKSFQGVEVEIMNALGKALN 260
            |....||||.:......:|:.|..|.|......|.|:.:    ...|.:||..:::::||...|.
Human   447 WNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLG 511

  Fly   261 FK-PVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHL 324
            |. .:|..|:.               .|||...|| ..||      ||.|:....|...|..|.:
Human   512 FNYEIYVAPDH---------------KYGSPQEDG-TWNG------LVGELVFKRADIGISALTI 554

  Fly   325 FQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLN 389
            ......:|:.:..:....:..|...:.........:.||...:|..:..::.:||.:.|.:::||
Human   555 TPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLN 619

  Fly   390 --AIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRS--SKGDRMPRDLFDGYTNCIL 450
              .:..|:::|               ..:|..:.|     .|.|  .:|..:|      ||.  |
Human   620 PPRLQMGSMTS---------------TTLYNSMWF-----VYGSFVQQGGEVP------YTT--L 656

  Fly   451 LTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR-S 514
            .|                  |::.|.:|::.::::::|.|:..|.|.......:|.:|:||.: :
Human   657 AT------------------RMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQT 703

  Fly   515 HIPPST---------------GATENRQFFLEANDEVARKVGEKMEVFGYSDDLTSRIAKGQCAY 564
            .||..|               ...|....:.:....:.|..|.:..|. .|.....::..|..|:
Human   704 EIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL-ESQAGIQKVKYGNYAF 767

  Fly   565 YDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGG----LIAK 625
            ..:...|.|:.:.|...| .:.:...|......:|::..|..:......|..|.:.|    |..|
Human   768 VWDAAVLEYVAINDPDCS-FYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHK 831

  Fly   626 W--------LKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAERW 674
            |        |..:::      ..|:...::|:.|...|..|..|.|:|....:.|.|
Human   832 WWPKNGQCDLYSSVD------TKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	48/261 (18%)
GRID2	XP_011530195.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740