Protein Alignment Ir68a and GRID1

DIOPT Version :9

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 100/525 - (19%)
• Similarity: 192/525 - (36%)
• Gaps: 123/525 - (23%)

  Fly   194 MKNIANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWA----NATKSFQGVEVEIMNA 254
            |:.:|.|:..|||||.:......|.|.|.:|.|......|.|:.|    ...|.::|..:::::|
Human   409 MRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDA 473

  Fly   255 LGKALNFK-PVYYKP-----NQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAH 313
            |.|||.|| .:|..|     :|..|..|                     ||      ::.|:.:.
Human   474 LAKALGFKYEIYQAPDGRYGHQLHNTSW---------------------NG------MIGELISK 511

  Fly   314 SARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVV 378
            .|..||..:.:......:|:.|..:....:..|..:.....|..:...||...:|..:..::.||
Human   512 RADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV 576

  Fly   379 GTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFD 443
            |.:.:.::.:.|:...:.:..     ||:.:..:...|:
Human   577 GVLIFVLNRIQAVRAQSAAQP-----RPSASATLHSAIW-------------------------- 610

  Fly   444 GYTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILA-----NPAARV 503
                   :.|...:.........:..:|::.|.:|::.:::.::|.|:..|.|.     ||
Human   611 -------IVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNP---- 664

  Fly   504 TIDTLEDLLRSHIPPSTGATENR---QFF-------LEAND---EVARKVGEKMEVFGYSDDLTS 555
             |.|.:||.: .:..|.|...:.   ::|       ||.:.   |:.|.:.:.    |.:|:..|
Human   665 -IRTFQDLSK-QVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKN----GGADNCVS 723

  Fly   556 -------RIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDAS 613
                   :..||..|:..:...:.|..:.|:..| :.::...:......:|::..|..:......
Human   724 SPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCS-VTVIGNSISSKGYGIALQHGSPYRDLFSQR 787

  Fly   614 IQHLAEGG----LIAKWLK-----DAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTL 669
            |..|.:.|    |..||..     |...|..|:|..:.   :.:..|...|..|.||.:::.|..
Human   788 ILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKS---LKLHSFAGVFCILAIGLLLACLVA 849

  Fly   670 LAERW 674
            ..|.|
Human   850 ALELW 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	45/265 (17%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		10/26 (38%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	6/13 (46%)
		ANF_receptor	41..400	CDD:279440
		PBP2_iGluR_delta_1	436..806	CDD:270448	78/445 (18%)
		Lig_chan	564..841	CDD:278489	53/328 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740