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Protein Alignment Ir68a and GRIA2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	719	Identity:	134/719 - (18%)
Similarity:	245/719 - (34%)	Gaps:	219/719 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DLQ-RPSRQVELFVKAIKSSDCELNVITILNGWQVQRFLGYIY--------DNRSLNMQKKFVLL 146
            ||: :..|:|.|..:..|.:|....||||  |..|:   ||.|        |...|.:|.....:
Human   198 DLELKKERRVILDCERDKVNDIVDQVITI--GKHVK---GYHYIIANLGFTDGDLLKIQFGGANV 257

  Fly   147 HDLRLFESD------MIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILS--GVLVMKN------- 196
            ...::.:.|      .|..||...:     ::....:| :||.:...|:  .|.||..
Human   258 SGFQIVDYDDSLVSKFIERWSTLEE-----KEYPGAHT-TTIKYTSALTYDAVQVMTEAFRNLRK 316

  Fly   197 --------------IAN----WELG------------KGLNGRILF------------------- 212
                          :||    |..|            :||:|.|.|
Human   317 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTN 381

  Fly   213 ----------ADK-------------TSNLFGTSLPVAISEHVPMVL------WANATKSFQGVE 248
                      .||             ||.|...::.|......|.|:      .....:.::|..
Human   382 GPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYC 446

  Fly   249 VEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAH 313
            |::...:.|...||   ||        .|.:..|   .||:.:.|....||      :|.|:...
Human   447 VDLAAEIAKHCGFK---YK--------LTIVGDG---KYGARDADTKIWNG------MVGELVYG 491

  Fly   314 SARFAIGDLHLFQVYLKLVELSAPHNFECLTFL--TPESSTDNSWQTFILPFSAGMWVGVLLSLF 376
            .|..||..|.:..|..::::.|.|.....::.:  .|:.|....: :|:.|.:..:|:.::.:..
Human   492 KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF-SFLDPLAYEIWMCIVFAYI 555

  Fly   377 VVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDL 441
            .|..|.:.:|                        ...|..:....|...    |.::......:.
Human   556 GVSVVLFLVS------------------------RFSPYEWHTEEFEDG----RETQSSESTNEF 592

  Fly   442 FDGYTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTID 506
              |..|.:..:....:.......||:...|::.|.:|.:.::::::|.|:..|.|........|:
Human   593 --GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 655

  Fly   507 TLEDLLR-SHIPPST---GATENRQFFLEANDEVARKVGEKMEVFGYSDD------------LTS 555
            :.|||.: :.|...|   |:|  ::||  ...::|  |.:||..:..|.:            ...
Human   656 SAEDLSKQTEIAYGTLDSGST--KEFF--RRSKIA--VFDKMWTYMRSAEPSVFVRTTAEGVARV 714

  Fly   556 RIAKGQCAYYDNEFYLRYLRV------------ADESGSALHIMKECVLYMPVVLAMEKNSALKP 608
            |.:||:.||........|:..            .|..|..              :|..|.|:|:.
Human   715 RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG--------------IATPKGSSLRT 765

  Fly   609 RVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQE-ALMNIQKFWSSFVALLIGYVISMLT 668
            .|:.::..|:|.|::    .||..|..|....::.:::: :.:::......|..|:.|..::||.
Human   766 PVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLV 830

  Fly   669 LLAE 672
            .|.|
Human   831 ALIE 834

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.