Protein Alignment Ir68a and GRIA1

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 839
• Identity: 155/839 - (18%)
• Similarity: 277/839 - (33%)
• Gaps: 288/839 - (34%)

  Fly     7 LIVAFISLAMATSIPIPIANPAPLSGYEMQLKILLQKILWVANVKRCFAVITDDLHYP------I 65
            |.|.||:    .|.|:..:|.     :.:||:..||..|        .::|.   ||.      |
Human   114 LHVCFIT----PSFPVDTSNQ-----FVLQLRPELQDAL--------ISIID---HYKWQKFVYI 158

  Fly    66 YDRIFFESVGRRVI-----------PFFVMRTNES------DDLQRPSRQVELFVKAIKSSDCE- 112
            ||.....||.::|:           ...::.|.|.      .||::...::.:.       |||
Human   159 YDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV-------DCES 216

  Fly   113 --LNVITILNGWQVQRFLGYIYDNRSLNMQKKFVLLH-----------DLRLFESDMIHLWSV-- 162
              ||.|           ||.|     :.::|..:..|           ||..|:....::...
Human   217 ERLNAI-----------LGQI-----IKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQL 265

  Fly   163 --FIDAIFLK--RQLDN--------------KYTISTIAFPGILSGVLVMKN------------- 196
              :.|.|..|  :|..|              ||| |.:.:    .||.||..
Human   266 VNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYT-SALTY----DGVKVMAEAFQSLRRQRIDIS 325

  Fly   197 --------IAN----WELG------------KGLNGRILF------------------------- 212
                    :||    |..|            :||.|.:.|
Human   326 RRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 390

  Fly   213 ------------------ADKTSNLFGTSLPVAISEHVPMVLWANATK-----SFQGVEVEIMNA 254
                              .|.:|....|.:...|.|...::|..||.:     .::|..||:...
Human   391 YWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAE 455

  Fly   255 LGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAI 319
            :.|.:.:.   |:           |:..:...||:.:||..|.||      :|.|:....|..|:
Human   456 IAKHVGYS---YR-----------LEIVSDGKYGARDPDTKAWNG------MVGELVYGRADVAV 500

  Fly   320 GDLHLFQVYLKLVELSAPHNFECLTFL--TPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVF 382
            ..|.:..|..::::.|.|.....::.:  .|:.|....: :|:.|.:..:|:.::.:...|..|.
Human   501 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF-SFLDPLAYEIWMCIVFAYIGVSVVL 564

  Fly   383 YAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTN 447
            :.:|                        ...|..:....|.....:..|.:.:..      |..|
Human   565 FLVS------------------------RFSPYEWHSEEFEEGRDQTTSDQSNEF------GIFN 599

  Fly   448 CILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLL 512
            .:..:....:.......||:...|::.|.:|.:.::::::|.|:..|.|........|::.|||.
Human   600 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA 664

  Fly   513 R-SHIPPST---GATENRQFFLEANDEVARKVGEKME-----VFGYSDD---LTSRIAKGQCAYY 565
            : :.|...|   |:|  ::||..:...|..|:...|:     ||..:.:   :..|.:||:.||.
Human   665 KQTEIAYGTLEAGST--KEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYL 727

  Fly   566 DNEFYLRYLRV------------ADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLA 618
            .......|:..            .|..|..              :|..|.|||:..|:.::..|.
Human   728 LESTMNEYIEQRKPCDTMKVGGNLDSKGYG--------------IATPKGSALRNPVNLAVLKLN 778

  Fly   619 EGGLI----AKWLKDAIEHLPAEALAQQE-ALMNIQKFWSSFVALLIGYVISMLTLLAE 672
            |.||:    .||..|..|.......::.: :.:::......|..|:.|..::||..|.|
Human   779 EQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	57/322 (18%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	60/335 (18%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	85/447 (19%)