DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir68a and Grin2a

DIOPT Version :9

Sequence 1:NP_648455.2 Gene:Ir68a / 39269 FlyBaseID:FBgn0036150 Length:704 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:470 Identity:93/470 - (19%)
Similarity:167/470 - (35%) Gaps:105/470 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 NATKSFQGVEVEIMNALGKALNFKPVYY-----KPNQTENMDWTELDGGASVAYGSGNPDGYAQN 298
            |..|..:|..::|:..|.:.:.|....|     |..:..|..|                     |
  Rat   451 NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVW---------------------N 494

  Fly   299 GTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPF 363
            |      ::.||....|..|:|.|.:.:...::|:.|.|.....::.:...|:...|...|:.||
  Rat   495 G------MIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPF 553

  Fly   364 SAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNV-----PMDPKIYRRISFR 423
            ||.:||.:.:.|.:|..:...:            .|:|..:..|||:     |..|      ||.
  Rat   554 SASVWVMMFVMLLIVSAIAVFV------------FEYFSPVGYNRNLAKGKAPHGP------SFT 600

  Fly   424 IAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP-RMPRNWPLRVLTGWYWIYCILLVAT 487
            |.                     ..|.|.:.::...::| :.|:....:::...:..:.::.:|:
  Rat   601 IG---------------------KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 644

  Fly   488 YRASFTAILANPAARVTIDTLED--LLRSH--IPP------STGATENRQFFLEANDEVARKVGE 542
            |.|:..|.:........:..|.|  ..|.|  .||      ..|:||..   :..|.....:...
  Rat   645 YTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERN---IRNNYPYMHQYMT 706

  Fly   543 KMEVFGYSDDLTS-RIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPV--VLAMEKNS 604
            :....|..|.|.| :..|.....|| ...|.|....|| |..|..:....::...  .:|::|.|
  Rat   707 RFNQRGVEDALVSLKTGKLDAFIYD-AAVLNYKAGRDE-GCKLVTIGSGYIFATTGYGIALQKGS 769

  Fly   605 ALKPRVD-ASIQHLAEG---GLIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVIS 665
            ..|.::| |.:|.:.:|   .|...||.....:...|.::.|   ::|......|..|.....:|
  Rat   770 PWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQ---LDIDNMAGVFYMLAAAMALS 831

  Fly   666 MLTLLAER---WHFK 677
            ::|.:.|.   |..:
  Rat   832 LITFIWEHLFYWKLR 846

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir68aNP_648455.2 Lig_chan 429..661 CDD:278489 47/249 (19%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 84/421 (20%)
HisJ <458..>541 CDD:223904 19/109 (17%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 61/318 (19%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 5/41 (12%)