DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and gria2b

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	569	Identity:	106/569 - (18%)
Similarity:	206/569 - (36%)	Gaps:	139/569 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LWSVFIDAIFLKRQLDN-----KYTISTIAFPGILSGVLVMKNIANW-ELGKGLNGRI-LFADKT 216
            |..|.:|.:....|.|.     .||::.:....  :|.:   .|..| |:.|.:..:. ||.:.|
Zfish   346 LKQVRVDGLTGNIQFDQYGKRVNYTVNVMELKS--NGAV---KIGYWNEVDKMVVTKSDLFPNDT 405

  Fly   217 SNLFGTSLPVAISEHVPMV-LWANA-----TKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMD 275
            ..|...::.|......|.| |..||     .:.::|..|::...:.|...||   |:
Zfish   406 MGLENKTVIVTTILEAPYVMLKKNADLFMDNERYEGYCVDLAAEIAKHCGFK---YQ-------- 459

  Fly   276 WTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNF 340
             .::.|...  ||:.:.:....||      :|.|:....|..|:..|.:..|..::::.|.|...
Zfish   460 -LKIVGDGK--YGARDAETKIWNG------MVGELVYGKADIAVAPLTITLVREEVIDFSKPFMS 515

  Fly   341 ECLTFL--TPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAIS-----------FLNAII 392
            ..::.:  .|:.|....: :|:.|.:..:|:.::.:...|..|.:.:|           :.:..|
Zfish   516 LGISIMIKKPQKSKPGVF-SFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEYEDGQI 579

  Fly   393 NGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLL 457
            ..|.|:..|                                          |..|.:..:....:
Zfish   580 QTNESTNEF------------------------------------------GIFNSLWFSLGAFM 602

  Fly   458 YVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR-SHIPPST- 520
            .......||:...|::.|.:|.:.::::::|.|:..|.|........|::.|||.: :.|...|
Zfish   603 RQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTL 667

  Fly   521 --GATENRQFFLEANDEVARKV-----GEKMEVFGYSDD---LTSRIAKGQCAYYDNEFYLRYLR 575
              |:|  ::||..:...:..|:     |.:..||..:..   :..|.:||:.||........|:.
Zfish   668 DSGST--KEFFRRSKIALFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIE 730

  Fly   576 V------------ADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGGLI----A 624
            .            .|..|..              :|..|.|:|:..|:.::..|.|.||:    .
Zfish   731 QRKPCDTMKVGGNLDSKGYG--------------IATPKGSSLRNAVNLAVLKLNEQGLLDKLKN 781

  Fly   625 KWLKDAIEHLPAEALAQQE-ALMNIQKFWSSFVALLIGYVISMLTLLAE 672
            ||..|..|.......:::: :.:::......|..|:.|..::||..|.|
Zfish   782 KWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALVE 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	48/260 (18%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	12/53 (23%)
		ANF_receptor	55..377	CDD:279440	7/30 (23%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	82/458 (18%)
		Lig_chan	542..820	CDD:278489	56/335 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740