DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and Grin2d

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	693	Identity:	127/693 - (18%)
Similarity:	234/693 - (33%)	Gaps:	200/693 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 FFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQ-VQRFLGYI----YDNRSLNMQ 140
            |.|......|||   :|:|            ...|..:..|.| :.|..|::    :|.|:.|
Mouse   307 FAVRSAGWRDDL---ARRV------------AAGVAVVARGAQALLRDYGFLPELGHDCRAQN-- 354

  Fly   141 KKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNK-YTISTIAF---PGILSGVLVMKNIANWE 201
                     |....:.:|.:       |:....||: |:.:...|   |.::  |:.:.....||
Mouse   355 ---------RTHRGESLHRY-------FMNITWDNRDYSFNEDGFLVNPSLV--VISLTRDRTWE 401

  Fly   202 LGKGLN--------------GRILF-ADKTSNLFGTSL------------PVA---ISEHVPMVL 236
            :.....              ||.|. .|.|.:|...:|            |::   |.:.||...
Mouse   402 VVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRS 466

  Fly   237 WANATKSF------------------QGVEVEIMNALGKALNFK-PVYYKPNQTENMDWTELDGG 282
            ..|.|.|.                  :|..::|:..|...:.|. .:|...|
Mouse   467 QLNRTHSLVAPRSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTN------------- 518

  Fly   283 ASVAYGSGNPDGYAQNGTHIDSM---LVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLT 344
                         .::|..||.:   ::.||....|..|||.|.:.:...::|:.|.|.....::
Mouse   519 -------------GKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGIS 570

  Fly   345 FLTPESSTDNSWQTFIL-----------PFSAGMWVGV-LLSLFVVGTVFYAISFLNAI-INGNV 396
            .:...|:...|...|:.           |:|..:||.: ::.|.||....:...:|:.: .|.::
Mouse   571 VMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSL 635

  Fly   397 SSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVAL 461
            ::.    .||..:           :|.|..|                     |.|.::::...::
Mouse   636 ATG----KRPGGS-----------TFTIGKS---------------------IWLLWALVFNNSV 664

  Fly   462 P-RMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLL----RSHIPP--- 518
            | ..||....:::...:..:.::.:|:|.|:..|.:.......|:..|.|..    :...||
Mouse   665 PVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKF 729

  Fly   519 ---STGATEN--RQFFLEANDEVARKVGEKMEVFGYSDDLTSRIAKGQCAYYDNEFYLRYLRVAD 578
               ..|:||.  |..:.:.:..:.|....::|     :.||...|....|:..:...|.|:...|
Mouse   730 GTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVE-----EALTQLKAGKLDAFIYDAAVLNYMARKD 789

  Fly   579 ESGSALHIMKECVLYMP-VVLAMEKNSALKPRVD-ASIQHLAEGG---LIAKWLKDAIEHLPAEA 638
            |....:.|....|.... ..:|:.|.|..|..:| |.:|.|.:..   |...||.....:...|.
Mouse   790 EGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEV 854

  Fly   639 LAQQEALMNIQKFWSSFVALLIGYVISMLTLLAER---WHFKH 678
            ::.:   ::|......|..||:...:|:|....|.   |..:|
Mouse   855 MSSK---LDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRH 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	46/249 (18%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	26/142 (18%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	86/483 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830