Protein Alignment Ir68a and Grin2b

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 761
• Identity: 149/761 - (19%)
• Similarity: 257/761 - (33%)
• Gaps: 222/761 - (29%)

  Fly     7 LIVAFISLAMATSIPIPIANPAPLSGYEMQLKILLQKILWVANVKRCFAVITDDL--HYPI---- 65
            :|:.:.:...||.| ..:||...|:||         ...|:  |....|..||.:  .:|.
Mouse   227 IILLYCTKEEATYI-FEVANSVGLTGY---------GYTWI--VPSLVAGDTDTVPSEFPTGLIS 279

  Fly    66 --YDRIFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQVQRFL 128
              ||...:....|......::.|..||.|...|     |:...||| |
Mouse   280 VSYDEWDYGLPARVRDGIAIITTAASDMLSEHS-----FIPEPKSS-C----------------- 321

  Fly   129 GYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQL---DNKYTISTIAFPGILSG 190
               |:.            |:.|:::|:|::.:  .|:..|..|.|   ::.|.:    .|.::
Mouse   322 ---YNT------------HEKRIYQSNMLNRY--LINVTFEGRNLSFSEDGYQM----HPKLV-- 363

  Fly   191 VLVMKNIANWE-LGKGLNGRILFADK---------------TSNLFGTSLPVAISEHVPMV---- 235
            ::::.....|| :||       :.||               |.......|.:...|..|.|
Mouse   364 IILLNKERKWERVGK-------WKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421

  Fly   236 -------------------LWANAT--------KSFQGVEVEIMNALGKALNFKPVYY-----KP 268
                               :..|.|        |..:|..::|:..:.|::.|....|     |.
Mouse   422 VDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKH 486

  Fly   269 NQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVE 333
            .:..|..|                     ||      ::.||....|..|:|.|.:.:...::|:
Mouse   487 GKKINGTW---------------------NG------MIGEVVMKRAYMAVGSLTINEERSEVVD 524

  Fly   334 LSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTV-FYAISFLNAIINGNVS 397
            .|.|.....::.:...|:...|...|:.||||.:||.:.:.|.:|..| .:...:.:.:
Mouse   525 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV------ 583

  Fly   398 SEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP 462
             .:.|||...|. |..|      ||.|.                     ..|.|.:.::...::|
Mouse   584 -GYNRCLADGRE-PGGP------SFTIG---------------------KAIWLLWGLVFNNSVP 619

  Fly   463 -RMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLL----RSHIPP---- 518
             :.|:....:::...:..:.::.:|:|.|:..|.:........:..|.|..    ....||
Mouse   620 VQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFG 684

  Fly   519 --STGATEN--RQFFLEANDEVARKVGEKMEVFGYSDDLTS-RIAKGQCAYYDNEFYLRYLRVAD 578
              ..|:||.  |..:.|.:..:.     |....|..|.|.| :..|.....|| ...|.|:...|
Mouse   685 TVPNGSTERNIRNNYAEMHAYMG-----KFNQRGVDDALLSLKTGKLDAFIYD-AAVLNYMAGRD 743

  Fly   579 ESGSALHIMKECVLYMP-VVLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAEA 638
            |....:.|....|.... ..:|::|:|..|.:||.:|..|...|    |.|.||.....:...|.
Mouse   744 EGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEV 808

  Fly   639 LAQQEALMNIQKFWSSFVALLIGYVISMLTLLAER---WHFKHIVM 681
            ::.|   ::|......|..|.....:|::|.:.|.   |.|:|..|
Mouse   809 MSSQ---LDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFM 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	63/313 (20%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	45/225 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	91/467 (19%)
		NMDAR2_C	840..1482	CDD:463148	4/12 (33%)