DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and Grin2a

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	470	Identity:	94/470 - (20%)
Similarity:	167/470 - (35%)	Gaps:	105/470 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 NATKSFQGVEVEIMNALGKALNFKPVYY-----KPNQTENMDWTELDGGASVAYGSGNPDGYAQN 298
            |..|..:|..::|:..|.:.:.|....|     |..:..|..|                     |
Mouse   451 NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVW---------------------N 494

  Fly   299 GTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPF 363
            |      ::.||....|..|:|.|.:.:...::|:.|.|.....::.:...|:...|...|:.||
Mouse   495 G------MIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPF 553

  Fly   364 SAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNV-----PMDPKIYRRISFR 423
            ||.:||.:.:.|.:|..:...:            .|:|..:..|||:     |..|      ||.
Mouse   554 SASVWVMMFVMLLIVSAIAVFV------------FEYFSPVGYNRNLAKGKAPHGP------SFT 600

  Fly   424 IAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP-RMPRNWPLRVLTGWYWIYCILLVAT 487
            |.                     ..|.|.:.::...::| :.|:....:::...:..:.::.:|:
Mouse   601 IG---------------------KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 644

  Fly   488 YRASFTAILANPAARVTIDTLED--LLRSH--IPP------STGATENRQFFLEANDEVARKVGE 542
            |.|:..|.:........:..|.|  ..|.|  .||      ..|:||..   :..|.....:...
Mouse   645 YTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERN---IRNNYPYMHQYMT 706

  Fly   543 KMEVFGYSDDLTS-RIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPV--VLAMEKNS 604
            |....|..|.|.| :..|.....|| ...|.|....|| |..|..:....::...  .:|::|.|
Mouse   707 KFNQRGVEDALVSLKTGKLDAFIYD-AAVLNYKAGRDE-GCKLVTIGSGYIFATTGYGIALQKGS 769

  Fly   605 ALKPRVD-ASIQHLAEG---GLIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVIS 665
            ..|.::| |.:|.:.:|   .|...||.....:...|.::.|   ::|......|..|.....:|
Mouse   770 PWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQ---LDIDNMAGVFYMLAAAMALS 831

  Fly   666 MLTLLAER---WHFK 677
            ::|.:.|.   |..:
Mouse   832 LITFIWEHLFYWKLR 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	48/249 (19%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	85/421 (20%)
		HisJ	<458..>541	CDD:223904	19/109 (17%)
		Lig_chan	556..828	CDD:278489	62/318 (19%)
		NMDAR2_C	839..1464	CDD:287527	1/8 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840