Protein Alignment Ir68a and Grik1

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 616
• Identity: 125/616 - (20%)
• Similarity: 210/616 - (34%)
• Gaps: 163/616 - (26%)

  Fly   129 GYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVL- 192
            |.|..|::..::|.|.|                   |.|.||.:...|.:       |.:|..|
Mouse   374 GRITFNKTDGLRKDFDL-------------------DIISLKEEGTEKAS-------GEVSKHLY 412

  Fly   193 -VMKNIANWELGKGLNGRILFADKTSN----LFGTSLPVAISEHVPMVLWANATK------SFQG 246
             |.|.|..|....|||......|:::|    |...:|.|......|.|::..:.|      .|:|
Mouse   413 KVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEG 477

  Fly   247 VEVEIMNALGKALNF-KPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEV 310
            ..::::..|...|.| ..|...|           ||    .||:.|..| ..||      :|.|:
Mouse   478 YCLDLLKELSNILGFLYDVKLVP-----------DG----KYGAQNDKG-EWNG------MVKEL 520

  Fly   311 AAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGM 367
            ..|.|..|:..|.:..|..|:::.|.|       |:|        ..:.|:....:|:.|.|..:
Mouse   521 IDHRADLAVAPLTITYVREKVIDFSKP-------FMTLGISILYRKPNGTNPGVFSFLNPLSPDI 578

  Fly   368 WVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSS 432
            |:.|||:...|..|.:.|:....          :....|:   |.:|
Mouse   579 WMYVLLACLGVSCVLFVIARFTP----------YEWYNPH---PCNP------------------ 612

  Fly   433 KGDRMPRDLFD-GYT--NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTA 494
                 ..|:.: .:|  |........|:......||:....|::.|.:|.:.::::::|.|:..|
Mouse   613 -----DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAA 672

  Fly   495 ILANPAARVTIDTLEDLLRSHIPPSTGATEN---RQFFLEANDEVARKVG--EKMEVFGYSDDLT 554
            .|........||:.:||.: ......||..:   ..||.::      |:.  |||..| .|....
Mouse   673 FLTVERMESPIDSADDLAK-QTKIEYGAVRDGSTMTFFKKS------KISTYEKMWAF-MSSRQQ 729

  Fly   555 SRIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEK--------NSALKPRVD 611
            |.:.|.............|..:.:.:.......:.|.|.....|...|        .|..:.::.
Mouse   730 SALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKIT 794

  Fly   612 ASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAE 672
            .:|..|.|.|.:    .||.:.  ...|.|...:..|| .::.....|:.|..|.|:|:...:.|
Mouse   795 IAILQLQEEGKLHMMKEKWWRG--NGCPEEDSKEASAL-GVENIGGIFIVLAAGLVLSVFVAIGE 856

  Fly   673 --------------------RWHFKHIVMKH 683
                                |::|::.|..|
Mouse   857 FIYKSRKNNDIEQKGKSSRLRFYFRNKVRFH 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	57/313 (18%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	21/82 (26%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	87/441 (20%)