DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and Grid2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	515	Identity:	101/515 - (19%)
Similarity:	185/515 - (35%)	Gaps:	107/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 MKNIANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWA----NATKSFQGVEVEIMNA 254
            ::.:..|....||||.:......:|:.|..|.|......|.|:.:    ...|.:||..:::::|
Mouse   413 VRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDA 477

  Fly   255 LGKALNFK-PVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFA 318
            |...|.|. .:|..|:.               .|||...|| ..||      ||.|:....|...
Mouse   478 LSNYLGFNYEIYVAPDH---------------KYGSPQEDG-TWNG------LVGELVFKRADIG 520

  Fly   319 IGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFY 383
            |..|.:......:|:.:..:....:..|...:.........:.||...:|..:..::.:||.:.|
Mouse   521 ISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVY 585

  Fly   384 AISFLN--AIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRS--SKGDRMPRDLFDG 444
            .:::||  .:..|:::|               ..:|..:.|     .|.|  .:|..:|
Mouse   586 LLNWLNPPRLQMGSMTS---------------TTLYNSMWF-----VYGSFVQQGGEVP------ 624

  Fly   445 YTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLE 509
            ||.  |.|                  |::.|.:|::.::::::|.|:..|.|.......:|.:|:
Mouse   625 YTT--LAT------------------RMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQ 669

  Fly   510 DLLR-SHIPPST---------------GATENRQFFLEANDEVARKVGEKMEVFGYSDDLTSRIA 558
            ||.: :.||..|               ...|....:.:....:.|..|.:..|. .|.....::.
Mouse   670 DLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL-ESQAGIQKVK 733

  Fly   559 KGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGG-- 621
            .|..|:..:...|.|:.:.|...| .:.:...|......:|::..|..:......|..|.:.|
Mouse   734 YGNYAFVWDAAVLEYVAINDPDCS-FYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDM 797

  Fly   622 --LIAKWLK-----DAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAERW 674
              |..||..     |....:.|:   |:...::|:.....|..|..|.|:|.|..:.|.|
Mouse   798 DILKHKWWPKNGQCDLYSSVDAK---QKGGALDIKSLAGVFCILAAGIVLSCLIAVLETW 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	48/258 (19%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	5/15 (33%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	83/435 (19%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846318
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830