Protein Alignment Ir68a and Gria4

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: XP_006509904.1
• Gene: Gria4 / 14802
• MGIID: 95811
• Length: 912
• Species: Mus musculus
• Alignment Length: 822
• Identity: 155/822 - (18%)
• Similarity: 283/822 - (34%)
• Gaps: 258/822 - (31%)

  Fly    15 AMATSIPIPIANPA-PLSG---YEMQLK--------ILLQKILWVANVKRCFAVITD-DLHYPIY 66
            :..:::.|.:..|: |..|   :.:||:        .||....|     .||..:.| |..|.|.
Mouse   108 SFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEW-----NCFVFLYDTDRGYSIL 167

  Fly    67 DRIFFESVGR---RVIPFFVMRTNE------SDDLQRPSRQVELFVKAIKSSDCEL----NVI-- 116
            ..| .|..|:   .|....|...|:      .::|.|  ||.:.||     .|||:    |::
Mouse   168 QAI-MEKAGQNGWHVSAICVENFNDVSYRQLLEELDR--RQEKKFV-----IDCEIERLQNILEQ 224

  Fly   117 TILNGWQVQRFLGYIYDNRSLNMQ----KKFVLLH--------DLRLFESDMI----HLWSVFID 165
            .:..|..|:   ||.|...:|..:    ::|:  |        .|..|.:.|:    ..|.....
Mouse   225 IVSVGKHVK---GYHYIIANLGFKDISLERFI--HGGANVTGFQLVDFNTPMVTKLMDRWKKLDQ 284

  Fly   166 AIFLKRQLDNKYTISTIAFPGIL---------------------SGVLVMKNIANWELG------ 203
            ..:...:...||| |.:.:.|:|                     :|..:....|.|..|
Mouse   285 REYPGSETPPKYT-SALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERT 348

  Fly   204 ------KGLNGRILF-----------------------------ADK-------------TSNLF 220
                  :||.|.:.|                             .||             |:.:.
Mouse   349 LKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIE 413

  Fly   221 GTSLPVAISEHVPMVLWANATKSFQGVE------VEIMNALGKALNFKPVYYK----PNQTENMD 275
            ..::.|......|.|::....:.|:|.:      |::.:.:.|.:..|   ||    |
Mouse   414 NRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIK---YKIAIVP------- 468

  Fly   276 WTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNF 340
                ||    .||:.:.|....||      :|.|:....|..||..|.:..|..::::.|.|...
Mouse   469 ----DG----KYGARDADTKIWNG------MVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMS 519

  Fly   341 ECLTFL--TPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRC 403
            ..::.:  .|:.|....: :|:.|.:..:|:.::.:...|..|.:.:|             .|..
Mouse   520 LGISIMIKKPQKSKPGVF-SFLDPLAYEIWMCIVFAYIGVSVVLFLVS-------------RFSP 570

  Fly   404 LRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALPRMPRNW 468
            ...:...|.|.|               ....|:.|.:.  |..|.:..:....:.......||:.
Mouse   571 YEWHTEEPEDGK---------------EGPSDQPPNEF--GIFNSLWFSLGAFMQQGCDISPRSL 618

  Fly   469 PLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR-SHIPPST---GATENRQFF 529
            ..|::.|.:|.:.::::::|.|:..|.|........|::.|||.: :.|...|   |:|  ::||
Mouse   619 SGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGST--KEFF 681

  Fly   530 LEANDEVARKVGEKMEVFGYSDD------------LTSRIAKGQCAYYDNEFYLRYLRV------ 576
              ...::|  |.|||..:..|.:            ...|.:||:.|:........|:..
Mouse   682 --RRSKIA--VYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDT 742

  Fly   577 ------ADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGGLI----AKWLKDAI 631
                  .|..|..              :|..|.|:|:..|:.::..|:|.|::    .||..|..
Mouse   743 MKVGGNLDSKGYG--------------VATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKG 793

  Fly   632 EHLPAEALAQQE-ALMNIQKFWSSFVALLIGYVISMLTLLAE 672
            |..|.::.::.: :.:::......|..|:.|..::||..|.|
Mouse   794 ECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	59/326 (18%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	59/310 (19%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	86/455 (19%)