DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grid2

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_031759030.1	Gene:	grid2 / 100487676	XenbaseID:	XB-GENE-955038	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	99/517 - (19%)
Similarity:	191/517 - (36%)	Gaps:	111/517 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 MKNIANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWA----NATKSFQGVEVEIMNA 254
            ::.:..|....||||.:......:|:.|..|.||.....|.|:.:    ...|.:||..:::::|
Frog   413 IRKLGFWNPVTGLNGSLTDRKLENNMRGVVLRVATVLEEPFVMVSENVLGKPKKYQGFSIDVLDA 477

  Fly   255 LGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAI 319
            |...|.||...|..:..:              |||...|| :.||      |:.|:....|...|
Frog   478 LSSYLGFKYEIYVASDHK--------------YGSPQADG-SWNG------LIGELLLKRADMGI 521

  Fly   320 GDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYA 384
            ..|.:......:|:.:..:....:..|..::.........:.||...:|..:..::.:||.:.|.
Frog   522 SALTITPDRENVVDFTTRYMDYSVGVLLRKAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYL 586

  Fly   385 ISFLN--AIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRS--SKGDRMPRDLFDGY 445
            :::||  .:..|:::|               ..:|..:.|     .|.|  .:|..:|      |
Frog   587 LNWLNPPRLQMGSMTS---------------TTLYNSMWF-----VYGSFVQQGGEVP------Y 625

  Fly   446 TNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLED 510
            |.  |.|                  |::.|.:|::.::::::|.|:..|.|.......:|.:|:|
Frog   626 TT--LAT------------------RMMMGAWWLFALIVISSYTANLAAFLTISRIESSIQSLQD 670

  Fly   511 LLR-SHIPPST---------------GATENRQFFLEANDEVARKVGEKMEVFGYSDDLTSRIAK 559
            |.| :.||..|               ...|....:.:....:.|..|.:..|....:.: .::..
Frog   671 LSRQTDIPYGTVFDSAVYEHVRVKGMNPFERDSMYSQMWRMINRSNGSENNVQESLEGI-QKVKH 734

  Fly   560 GQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGG--- 621
            |..|:..:...|.|:.:.|:..| .:.:...:......:|::..|..:......|..|.:.|
Frog   735 GNYAFVWDAAVLEYIAINDQDCS-FYTVGNTIADRGYGIALQHGSPYRDIFSQRILELQQNGDMD 798

  Fly   622 -LIAKW--------LKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAERW 674
             |..||        |..:::      ..|:.:.::|:.|...|..|..|.|:|....:.|.|
Frog   799 ILKHKWWPRNGQCELHSSMD------TKQKGSSLDIKSFSGVFCILAAGIVLSCFIAMVETW 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	47/261 (18%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:415822	5/15 (33%)
grid2	XP_031759030.1	PBP2_iGluR_delta_2	440..806	CDD:270449	82/434 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910