DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and grin3bb

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	763	Identity:	145/763 - (19%)
Similarity:	246/763 - (32%)	Gaps:	244/763 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LKILLQKILWVANVKRCFAVITDDLH---YPIYDRIFFESVGRRVIPFFVMRTNESDDLQRPSRQ 98
            |.:.|..:.|:..    ..:..|.||   .|: ..:.:..|..:.:.|::     ||.||..:|.
Zfish   272 LGLTLPTVHWIMG----HPLSPDALHSIGLPL-GLLAYGEVDHKPLDFYI-----SDALQLINRA 326

  Fly    99 VELFVKAIKSSDCEL--NVITIL----------NGWQVQRFL---------GYIYDNRSLNMQKK 142
            |.  ...:...|..|  |::...          :|..:.|||         |.:...|:|:
Zfish   327 VT--AATVVRPDLALIQNMVNCFDKPNKHELPSSGQYIARFLSNTSFVGLTGPVIVQRNLS---- 385

  Fly   143 FVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVMKNIANWELGK--- 204
                   |:..|..:|:||:..||:                      |......:.:||.|:
Zfish   386 -------RVHTSHKVHIWSLRRDAV----------------------GQPTWVTVGSWEGGRLNV 421

  Fly   205 -------GLNGRILFADKTSNLFG-------TSLPVA--------ISEHVPMVLW---------- 237
                   |.:.|    .:|....|       ...||:        :.|| |.|..
Zfish   422 EEQGLWQGSSPR----QRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEH-PFVFTREVDEDGNCP 481

  Fly   238 -----------------------ANATKSF---------QGVEVEIMNALGKALNFKPVYY---- 266
                                   |...|||         .|..::::..|.:.:||:...|
Zfish   482 AGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGD 546

  Fly   267 -KPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLK 330
             |....:...||.|.|...    ||..|           |.|...:.:|||            .|
Zfish   547 GKYGAVKGGQWTGLVGDLL----SGVAD-----------MAVTSFSINSAR------------SK 584

  Fly   331 LVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGN 395
            :::.::|.....|..|.....|......|:.|....||:|:.::|                   :
Zfish   585 VIDFTSPFFSTSLGILVRSKDTAAPIGAFMWPLHWSMWMGIFVAL-------------------H 630

  Fly   396 VSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLL-YV 459
            :::.|...........|.|....|:.                   :| .|::.:.|.|::|. ..
Zfish   631 ITALFLTLYEWKSPFGMTPHGRNRVK-------------------VF-SYSSALNLCYAILFGRT 675

  Fly   460 ALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLRSHIPPSTG--- 521
            ...:.|:.|..|.|...:.|:|:|::::|.|:..|::........:..:.|....|  ||.|
Zfish   676 VSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDAKLHH--PSQGFRF 738

  Fly   522 ------ATEN--RQFFLEANDEVARKVGEKMEVFGYSDDLTSRIAKGQC-AYYDNEFYLRYLRVA 577
                  :.|:  ::.|.|.: |..||..|.....|.:   |.:....|. |:..::..|.|....
Zfish   739 GTVRESSAEDYMKKSFPEMH-EYMRKFNEPTTPDGVA---TLKTDPPQLDAFIMDKALLDYEVSI 799

  Fly   578 DESGSALHIMKECVL--YMPVVLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPA 636
            |.....|.:.|...:  |   .:.:.:||.|...:...:......|    |..||.|  :.....
Zfish   800 DADCKLLTVGKPFAIEGY---GIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWYK--VVPCGK 859

  Fly   637 EALAQQEAL-MNIQKFWSSFVALLIGYVISMLTLLAERWHFKHIVMKH 683
            ...|..|.| |.|:.|...||.|.:|...::|||..|. .|..:|:.|
Zfish   860 RVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEH-AFYRLVLPH 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	54/251 (22%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	36/200 (18%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	84/470 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591174
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840