Protein Alignment Ir68a and grin2ca

DIOPT Version :10

• Sequence 1: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 667
• Identity: 121/667 - (18%)
• Similarity: 225/667 - (33%)
• Gaps: 184/667 - (27%)

  Fly    99 VELFVKAIKS------------SDCELNVITILNGWQVQRFLGYIYDNRSLNMQKKFVLLHDLRL 151
            |.:.||.::|            .||...:....||...:..|...::|...:......|::...:
Zfish   304 VAIVVKGVESFRKQRGFIPDGHMDCLSPIRPASNGTLYRHMLNVSWENTDFSFNSDGYLVNPSMI 368

  Fly   152 ---------------FESDMIHL----WSVFIDAIFLKRQLDNKY-TISTIAFPGILSGVLVMKN 196
                           :||.::.:    |..:  ..||:...||:: |::|:.
Zfish   369 IITLDRGRQWDKVGNYESGILQMRYPVWPRY--GTFLEPVSDNRHLTVATLE------------- 418

  Fly   197 IANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWANATKSF------------QGVEV 249
                      ....:..:....:.||.|    |..||....:|.|::.            :|..:
Zfish   419 ----------ERPFVIVEAVDPVTGTCL----SNTVPCRRQSNKTETIVGHTEPYTKLCCKGFCI 469

  Fly   250 EIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTH------IDSMLVD 308
            :|:..|.:.:.|....|                            ...||.|      |.:.::.
Zfish   470 DILKKLSRNIKFSYDLY----------------------------LVTNGKHGKLVRGIWNGMIG 506

  Fly   309 EVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGV-L 372
            ||....|..|||.|.:.:...::::.|.|.....::.:...|:...|...|:.|:|..:||.: :
Zfish   507 EVFYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFV 571

  Fly   373 LSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNV-----PMDPKIYRRISFRIAISRYRSS 432
            :.|.||....:...:.:.:             ..||::     |..|      :|.|..|
Zfish   572 MCLTVVAVTVFVFEYCSPV-------------GYNRSLVSAKDPGGP------TFTIGKS----- 612

  Fly   433 KGDRMPRDLFDGYTNCILLTYSMLLYVALP-RMPRNWPLRVLTGWYWIYCILLVATYRASFTAIL 496
                            :.|.:.::...::| ..|:....:::...:..:.::.:|:|.|:..|.:
Zfish   613 ----------------VWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFM 661

  Fly   497 ANPAARVTIDTLEDLL----RSHIPP------STGATEN--RQFFLEANDEVARKVGEKMEVFGY 549
            .......|:..|.|..    :...||      ..|:||.  |..:.|.:..:. |..:|    |.
Zfish   662 IQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIRSNYPEMHSHMV-KYNQK----GV 721

  Fly   550 SDDLTS-RIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMP-VVLAMEKNSALKPRVD- 611
            .|.|.| :..|.....|| ...|.|:...||....:.|....|.... ..:|::|.|..|..:|
Zfish   722 EDALNSLKTGKLDAFIYD-AAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKESRWKRPIDL 785

  Fly   612 ASIQHLAEGG---LIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAER 673
            |.:|.||:|.   |...||.....:...|.::.:   ::|......|..||:...:|:|....|.
Zfish   786 ALLQFLADGDTQKLQTVWLTGICRNEKKEVMSSK---LDIDNMAGVFYMLLVAMGLSLLVFAWEH 847

  Fly   674 ---WHFKHIVMKHPMYD 687
               |..:|.|.|....|
Zfish   848 LLYWKLRHSVRKSERLD 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	62/318 (19%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	13/88 (15%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	91/501 (18%)
		NMDAR2_C	847..>938	CDD:463148	5/18 (28%)