DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7600 and Fam91a1

DIOPT Version :9

Sequence 1:	NP_648453.1	Gene:	CG7600 / 39267	FlyBaseID:	FBgn0064766	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001121050.1	Gene:	Fam91a1 / 689997	RGDID:	1586304	Length:	838	Species:	Rattus norvegicus

Alignment Length:	940	Identity:	366/940 - (38%)
Similarity:	509/940 - (54%)	Gaps:	165/940 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VRGNVTWELLPVHLRSVLHNNQRDYEKFVFNYSLKNQLRFRGNLAAKVFRREQRYYELLIQKSIN 95
            :|.|..|..||.:::..|.|:||:|||.|..||::||||:|.||...|.:.|::|||.|::.|.:
  Rat     9 IRHNYPWSKLPTNVKQSLGNSQREYEKQVVLYSIRNQLRYRNNLVKHVKKDERKYYEELLKYSRD 73

  Fly    96 GLGAFPYHLADIVTKGLRVTPFNYYLDVLGQLLQSDKSYDTLPNFTAADCLRVLGIGRNEYLALI 160
            .|..:||||:||:.||||:|||:||..::..::.|:||||:|||||||||||:||||||:|:.|:
  Rat    74 HLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM 138

  Fly   161 SDMKTHTPRSLIFGSRPNPLDFLPRFPVRIHIEPWWRLDIGYVLEADIRYLSPAERGLLDDLIDF 225
            :..::    |..|..|....|.||..||.|.||.||.:..||:.|.||:..:..|:..:|.:||.
  Rat   139 NQCRS----SKKFFRRKTAHDLLPMKPVEIAIEAWWVVQAGYITEDDIKICTFPEKSAIDKIIDS 199

  Fly   226 GAQPAGKCDHDVVHSLYRKGLIYLDVPISGEDRISIPPLRNFVMNRVSGDYFENLLYKIFVSADE 290
            |.|.:|..|::||||||.||.||||||||.:..|::|||..||||||.|||||.||||||||.||
  Rat   200 GPQLSGSLDYNVVHSLYNKGFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDE 264

  Fly   291 HMTIAELAQMLQLELDSVKQAISFICRLGFAHRKEDLVNQTN-HSSWEGYNQQQTPDTPQITPLN 354
            |..:||||.:|:::|..||.|:|..|||||||:|..::|... ||||:        :.|.:..|
  Rat   265 HTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWK--------NVPSVNRL- 320

  Fly   355 YNLHTSSSFEFDQSPKSPKTPKEREKDKDKDSSSIGYLSSDGNTSDFSFANLNTTPQERVNNSDE 419
                           ||...|::.            .||.||..|        .:|.:..:::.:
  Rat   321 ---------------KSTLDPQKM------------LLSWDGGES--------RSPVQEASSATD 350

  Fly   420 QELSSELEQEDMCAPKQAAPSAAISAAVLPKSG--KRVGFLFDSTLTAFLMMGNLSPGLKNHAVT 482
            .:.:|   |||      .|.:|::|:..| .:|  ||:.||||||||||||||||||.||:||||
  Rat   351 TDTNS---QED------PADTASVSSLSL-STGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVT 405

  Fly   483 MFEVGKLCEESLDSFLAELEQVSLLDAEGEGDVSRYFAHAVILRSTICSLRHL------------ 535
            |||||||.:|||||||.|||:|   .:.|||:..|||.||:.||:||..|||.
  Rat   406 MFEVGKLSDESLDSFLIELEKV---QSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTSQPDQ 467

  Fly   536 ----LPGGLDLLRLECLEGLDQQTRDRVLEKKYKFIIAASPLTASLSHTFSI--PYFGQFLRSSD 594
                .|  |||||.|.|.|||..|..|||.|.|..:::.:|||..:....|.  .:.|..:  .:
  Rat   468 SNYGFP--LDLLRCESLLGLDPATCSRVLNKNYTLLVSMAPLTNEIRPVSSCTPQHIGPAI--PE 528

  Fly   595 VAPMWSKLFYNHITGYGPPSLLLCRGTVLKTLPRLFLGYGKLLVNILHSDAYVLNSEN-FRSLNS 658
            |:.:|.||:..||||.|||||||.:||.|:.||.:|.||.:||:.....|..|:.:.| ...||.
  Rat   529 VSSVWFKLYIYHITGQGPPSLLLSKGTRLRKLPDIFQGYDRLLITSWGHDPGVVPTSNVLTMLND 593

  Fly   659 QLKNGCVLLQGYGIRTAGALHYESFPFQAADTR----QAKWAAHRAVHKLSSLLDLRQQCGYITF 719
            .|.:..||:||:|:...|...:..|||..|:.:    :|....|:|:..|.|.:||:..|||:|.
  Rat   594 ALTHSAVLIQGHGLHGVGETVHIPFPFDEAELQGEFTRASMGVHKALQILRSKVDLQHFCGYVTM 658

  Fly   720 LNTGVPDLGCEDYELQVRLKPAQRQKRTSIAAPSKPNHVPTNEVTSFQLKSPDENHFAATPEHGP 784
            ||.                                     ::::.|.:|..       |:.|.|
  Rat   659 LNA-------------------------------------SSQLASRKLSD-------ASDERG- 678

  Fly   785 ANEFTAPDCSQVLASELAKCSSRADLVSQSSVEIEEISP--SVVQEEDATEE--WTLLDVNFGVP 845
                 .||        ||..|..........:.|||.|.  |..|...||.|  |..|::.||:|
  Rat   679 -----EPD--------LASSSDVNGSTESFEMVIEEASTDLSTKQNSGATAEADWVPLELCFGIP 730

  Fly   846 LFDVDTNTRICEQL-VQGLCSDANLEALPAAASQAQVLFLDFVQQ------CLYFEDDPA----- 898
            ||..:.|.::|::: ..||||..:|::|..::.:..:..|:||..      .|.|..:|.
  Rat   731 LFSSELNRKVCQKIATHGLCSKESLQSLLHSSRKLSLQVLNFVHSFQEGAATLDFHAEPGFSSVF 795

  Fly   899 RQSVQAARPLPHPRINLAFENGHVCHWNGR 928
            .||..|...:|.|..|:.|::|.:..|:||
  Rat   796 SQSSCADTGVPLPAKNVMFKDGILSEWSGR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7600	NP_648453.1	FAM91_N	32..336	CDD:291320	158/304 (52%)
CG7600	NP_648453.1	FAM91_C	452..922	CDD:291321	184/510 (36%)
Fam91a1	NP_001121050.1	FAM91_N	10..312	CDD:291320	159/305 (52%)
Fam91a1	NP_001121050.1	FAM91_C	374..821	CDD:291321	183/511 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341665
Domainoid	1	1.000	327	1.000	Domainoid score	I1140
eggNOG	1	0.900	-	-		E1_KOG3707
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13388
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1068
OMA	1	1.010	-	-		QHG54137
OrthoDB	1	1.010	-	-		D164905at2759
OrthoFinder	1	1.000	-	-		FOG0005587
OrthoInspector	1	1.000	-	-		oto98111
orthoMCL	1	0.900	-	-		OOG6_104766
Panther	1	1.100	-	-	LDO	PTHR28441
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4558
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770