Protein Alignment CG7600 and FAM91A1

DIOPT Version :10

• Sequence 1: NP_648453.1
• Gene: CG7600 / 39267
• FlyBaseID: FBgn0064766
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: NP_659400.3
• Gene: FAM91A1 / 157769
• HGNCID: 26306
• Length: 838
• Species: Homo sapiens
• Alignment Length: 938
• Identity: 360/938 - (38%)
• Similarity: 503/938 - (53%)
• Gaps: 161/938 - (17%)

  Fly    31 VRGNVTWELLPVHLRSVLHNNQRDYEKFVFNYSLKNQLRFRGNLAAKVFRREQRYYELLIQKSIN 95
            :|.|..|..||.::|..|.|:||:|||.|..||::||||:|.||...|.:.|:||||.|::.|.:
Human     9 IRHNYPWNKLPANVRQSLGNSQREYEKQVVLYSIRNQLRYRNNLVKHVKKDERRYYEELLKYSRD 73

  Fly    96 GLGAFPYHLADIVTKGLRVTPFNYYLDVLGQLLQSDKSYDTLPNFTAADCLRVLGIGRNEYLALI 160
            .|..:||||:||:.||||:|||:||..::..::.|:||||:|||||||||||:||||||:|:.|:
Human    74 HLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM 138

  Fly   161 SDMKTHTPRSLIFGSRPNPLDFLPRFPVRIHIEPWWRLDIGYVLEADIRYLSPAERGLLDDLIDF 225
            :..::    |..|..|....|.||..||.|.||.||.:..||:.|.||:..:..|:..:|.:||.
Human   139 NQCRS----SKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDS 199

  Fly   226 GAQPAGKCDHDVVHSLYRKGLIYLDVPISGEDRISIPPLRNFVMNRVSGDYFENLLYKIFVSADE 290
            |.|.:|..|::||||||.||.||||||||.:..|::|||..||||||.|||||.||||||||.||
Human   200 GPQLSGSLDYNVVHSLYNKGFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDE 264

  Fly   291 HMTIAELAQMLQLELDSVKQAISFICRLGFAHRKEDLVNQTN-HSSWEGYNQQQTPDTPQITPLN 354
            |..:||||.:|:::|..||.|:|..|||||||:|..::|... ||||:        :.|.:..|
Human   265 HTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWK--------NVPSVNRL- 320

  Fly   355 YNLHTSSSFEFDQSPKSPKTPKEREKDKDKDSSSIGYLSSDGNTSDFSFANLNTTPQERVNNSDE 419
                           ||...|::.            .||.||..|        .:|.:..:::.:
Human   321 ---------------KSTLDPQKM------------LLSWDGGES--------RSPVQEASSATD 350

  Fly   420 QELSSELEQEDMCAPKQAAPSAAISAAVLPKSG--KRVGFLFDSTLTAFLMMGNLSPGLKNHAVT 482
            .:.:|   |||      .|.:|::|:..| .:|  ||:.||||||||||||||||||.||:||||
Human   351 TDTNS---QED------PADTASVSSLSL-STGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVT 405

  Fly   483 MFEVGKLCEESLDSFLAELEQVSLLDAEGEGDVSRYFAHAVILRSTICSLRHL------------ 535
            |||||||.:|||||||.|||:|   .:.|||:..|||.||:.||:||..|||.
Human   406 MFEVGKLSDESLDSFLIELEKV---QSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQ 467

  Fly   536 ----LPGGLDLLRLECLEGLDQQTRDRVLEKKYKFIIAASPLTASLSHTFSI--PYFGQFLRSSD 594
                .|  |||||.|.|.|||..|..|||.|.|..:::.:|||..:....|.  .:.|..:  .:
Human   468 PNYGFP--LDLLRCESLLGLDPATCSRVLNKNYTLLVSMAPLTNEIRPVSSCTPQHIGPAI--PE 528

  Fly   595 VAPMWSKLFYNHITGYGPPSLLLCRGTVLKTLPRLFLGYGKLLVNILHSDAYVLNSEN-FRSLNS 658
            |:.:|.||:..|:||.|||||||.:||.|:.||.:|..|.:||:.....|..|:.:.| ...||.
Human   529 VSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVLTMLND 593

  Fly   659 QLKNGCVLLQGYGIRTAGALHYESFPFQAADTR----QAKWAAHRAVHKLSSLLDLRQQCGYITF 719
            .|.:..||:||:|:...|...:..|||...:.:    :.....|:|:..|.:.:||:..|||:|.
Human   594 ALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTM 658

  Fly   720 LNTGVPDLGCEDYELQVRLKPAQRQKRTSIAAPSKPNHVPTNEVTSFQLKSPDENHFAATPEHGP 784
            ||                                          .|.||  .|.....|:.|.|
Human   659 LN------------------------------------------ASSQL--ADRKLSDASDERG- 678

  Fly   785 ANEFTAPDCSQVLASELAKCSSRADLVSQSSVEIEEISPSVVQEEDATEE--WTLLDVNFGVPLF 847
                 .||.:.  .|::...:...::|    :|...|..:..|...||.|  |..|::.||:|||
Human   679 -----EPDLAS--GSDVNGSTESFEMV----IEEATIDSATKQTSGATTEADWVPLELCFGIPLF 732

  Fly   848 DVDTNTRICEQL-VQGLCSDANLEALPAAASQAQVLFLDFVQ------QCLYFEDDPA-----RQ 900
            ..:.|.::|.:: ..|||...:|:.|..::.:..:..|:||.      ..|....:|:     .|
Human   733 SSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQVLNFVHSFQEGASILDIHTEPSFSSLLSQ 797

  Fly   901 SVQAARPLPHPRINLAFENGHVCHWNGR 928
            |..|...:|.|..||.|::|.:..|:||
Human   798 SSCADMGVPLPAKNLIFKDGVLSEWSGR 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7600	NP_648453.1	FAM91_N	30..336	CDD:434094	160/305 (52%)
		FAM91_C	452..921	CDD:464235	175/507 (35%)
FAM91A1	NP_659400.3	FAM91_N	8..312	CDD:434094	161/306 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..367		10/49 (20%)
		FAM91_C	374..821	CDD:464235	175/509 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	670..690		6/27 (22%)