DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7600 and FAM91A1

DIOPT Version :9

Sequence 1:	NP_648453.1	Gene:	CG7600 / 39267	FlyBaseID:	FBgn0064766	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_659400.3	Gene:	FAM91A1 / 157769	HGNCID:	26306	Length:	838	Species:	Homo sapiens

Alignment Length:	938	Identity:	360/938 - (38%)
Similarity:	503/938 - (53%)	Gaps:	161/938 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VRGNVTWELLPVHLRSVLHNNQRDYEKFVFNYSLKNQLRFRGNLAAKVFRREQRYYELLIQKSIN 95
            :|.|..|..||.::|..|.|:||:|||.|..||::||||:|.||...|.:.|:||||.|::.|.:
Human     9 IRHNYPWNKLPANVRQSLGNSQREYEKQVVLYSIRNQLRYRNNLVKHVKKDERRYYEELLKYSRD 73

  Fly    96 GLGAFPYHLADIVTKGLRVTPFNYYLDVLGQLLQSDKSYDTLPNFTAADCLRVLGIGRNEYLALI 160
            .|..:||||:||:.||||:|||:||..::..::.|:||||:|||||||||||:||||||:|:.|:
Human    74 HLMLYPYHLSDIMVKGLRITPFSYYTGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM 138

  Fly   161 SDMKTHTPRSLIFGSRPNPLDFLPRFPVRIHIEPWWRLDIGYVLEADIRYLSPAERGLLDDLIDF 225
            :..::    |..|..|....|.||..||.|.||.||.:..||:.|.||:..:..|:..:|.:||.
Human   139 NQCRS----SKKFFRRKTARDLLPIKPVEIAIEAWWVVQAGYITEDDIKICTLPEKCAVDKIIDS 199

  Fly   226 GAQPAGKCDHDVVHSLYRKGLIYLDVPISGEDRISIPPLRNFVMNRVSGDYFENLLYKIFVSADE 290
            |.|.:|..|::||||||.||.||||||||.:..|::|||..||||||.|||||.||||||||.||
Human   200 GPQLSGSLDYNVVHSLYNKGFIYLDVPISDDSCIAVPPLEGFVMNRVQGDYFETLLYKIFVSIDE 264

  Fly   291 HMTIAELAQMLQLELDSVKQAISFICRLGFAHRKEDLVNQTN-HSSWEGYNQQQTPDTPQITPLN 354
            |..:||||.:|:::|..||.|:|..|||||||:|..::|... ||||:        :.|.:..|
Human   265 HTNVAELANVLEIDLSLVKNAVSMYCRLGFAHKKGQVINLDQLHSSWK--------NVPSVNRL- 320

  Fly   355 YNLHTSSSFEFDQSPKSPKTPKEREKDKDKDSSSIGYLSSDGNTSDFSFANLNTTPQERVNNSDE 419
                           ||...|::.            .||.||..|        .:|.:..:::.:
Human   321 ---------------KSTLDPQKM------------LLSWDGGES--------RSPVQEASSATD 350

  Fly   420 QELSSELEQEDMCAPKQAAPSAAISAAVLPKSG--KRVGFLFDSTLTAFLMMGNLSPGLKNHAVT 482
            .:.:|   |||      .|.:|::|:..| .:|  ||:.||||||||||||||||||.||:||||
Human   351 TDTNS---QED------PADTASVSSLSL-STGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVT 405

  Fly   483 MFEVGKLCEESLDSFLAELEQVSLLDAEGEGDVSRYFAHAVILRSTICSLRHL------------ 535
            |||||||.:|||||||.|||:|   .:.|||:..|||.||:.||:||..|||.
Human   406 MFEVGKLSDESLDSFLIELEKV---QSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQTAQPDQ 467

  Fly   536 ----LPGGLDLLRLECLEGLDQQTRDRVLEKKYKFIIAASPLTASLSHTFSI--PYFGQFLRSSD 594
                .|  |||||.|.|.|||..|..|||.|.|..:::.:|||..:....|.  .:.|..:  .:
Human   468 PNYGFP--LDLLRCESLLGLDPATCSRVLNKNYTLLVSMAPLTNEIRPVSSCTPQHIGPAI--PE 528

  Fly   595 VAPMWSKLFYNHITGYGPPSLLLCRGTVLKTLPRLFLGYGKLLVNILHSDAYVLNSEN-FRSLNS 658
            |:.:|.||:..|:||.|||||||.:||.|:.||.:|..|.:||:.....|..|:.:.| ...||.
Human   529 VSSVWFKLYIYHVTGQGPPSLLLSKGTRLRKLPDIFQSYDRLLITSWGHDPGVVPTSNVLTMLND 593

  Fly   659 QLKNGCVLLQGYGIRTAGALHYESFPFQAADTR----QAKWAAHRAVHKLSSLLDLRQQCGYITF 719
            .|.:..||:||:|:...|...:..|||...:.:    :.....|:|:..|.:.:||:..|||:|.
Human   594 ALTHSAVLIQGHGLHGIGETVHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTM 658

  Fly   720 LNTGVPDLGCEDYELQVRLKPAQRQKRTSIAAPSKPNHVPTNEVTSFQLKSPDENHFAATPEHGP 784
            ||                                          .|.||  .|.....|:.|.|
Human   659 LN------------------------------------------ASSQL--ADRKLSDASDERG- 678

  Fly   785 ANEFTAPDCSQVLASELAKCSSRADLVSQSSVEIEEISPSVVQEEDATEE--WTLLDVNFGVPLF 847
                 .||.:.  .|::...:...::|    :|...|..:..|...||.|  |..|::.||:|||
Human   679 -----EPDLAS--GSDVNGSTESFEMV----IEEATIDSATKQTSGATTEADWVPLELCFGIPLF 732

  Fly   848 DVDTNTRICEQL-VQGLCSDANLEALPAAASQAQVLFLDFVQ------QCLYFEDDPA-----RQ 900
            ..:.|.::|.:: ..|||...:|:.|..::.:..:..|:||.      ..|....:|:     .|
Human   733 SSELNRKVCRKIAAHGLCRKESLQNLLHSSRKLSLQVLNFVHSFQEGASILDIHTEPSFSSLLSQ 797

  Fly   901 SVQAARPLPHPRINLAFENGHVCHWNGR 928
            |..|...:|.|..||.|::|.:..|:||
Human   798 SSCADMGVPLPAKNLIFKDGVLSEWSGR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7600	NP_648453.1	FAM91_N	32..336	CDD:291320	160/304 (53%)
CG7600	NP_648453.1	FAM91_C	452..922	CDD:291321	176/508 (35%)
FAM91A1	NP_659400.3	FAM91_N	10..312	CDD:317093	161/305 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..367		10/49 (20%)
		FAM91_C	374..821	CDD:317094	175/509 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	670..690		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147807
Domainoid	1	1.000	329	1.000	Domainoid score	I1160
eggNOG	1	0.900	-	-		E1_KOG3707
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13388
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1168
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54137
OrthoDB	1	1.010	-	-		D164905at2759
OrthoFinder	1	1.000	-	-		FOG0005587
OrthoInspector	1	1.000	-	-		oto91016
orthoMCL	1	0.900	-	-		OOG6_104766
Panther	1	1.100	-	-	LDO	PTHR28441
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3588
SonicParanoid	1	1.000	-	-		X4558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800