DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7600 and fam91a1

DIOPT Version :9

Sequence 1:	NP_648453.1	Gene:	CG7600 / 39267	FlyBaseID:	FBgn0064766	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001107424.1	Gene:	fam91a1 / 100135267	XenbaseID:	XB-GENE-5796830	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	936	Identity:	356/936 - (38%)
Similarity:	496/936 - (52%)	Gaps:	155/936 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VRGNVTWELLPVHLRSVLHNNQRDYEKFVFNYSLKNQLRFRGNLAAKVFRREQRYYELLIQKSIN 95
            :|.|..|..||.::|..|.|:.::|||.|..||::||||:|.||...|.:.|::|||.|::.|.:
Frog     9 IRQNYPWAKLPANVRQSLGNSPKEYEKHVILYSIRNQLRYRVNLVKHVKKDERKYYEELLKYSRD 73

  Fly    96 GLGAFPYHLADIVTKGLRVTPFNYYLDVLGQLLQSDKSYDTLPNFTAADCLRVLGIGRNEYLALI 160
            .|..:||||:||:.||||:|||:||:.::..::.|:||||:|||||||||||:||||||:|:.|:
Frog    74 HLMLYPYHLSDIMVKGLRITPFSYYIGIMEDIMNSEKSYDSLPNFTAADCLRLLGIGRNQYIDLM 138

  Fly   161 SDMKTHTPRSLIFGSRPNPLDFLPRFPVRIHIEPWWRLDIGYVLEADIRYLSPAERGLLDDLIDF 225
            :..::    |..|..|....|.||..||.|.|||||.:..||:.|.||:..|..|:..:|.:||.
Frog   139 NQCRS----SKKFFRRKTARDLLPVKPVEISIEPWWVVQAGYITEDDIKICSTTEKRAIDKIIDS 199

  Fly   226 GAQPAGKCDHDVVHSLYRKGLIYLDVPISGEDRISIPPLRNFVMNRVSGDYFENLLYKIFVSADE 290
            |.|.||..|::.|||||.||.||||||||.:..|::|||..|||||:.|||||.||||||||.||
Frog   200 GPQLAGSLDYNTVHSLYNKGFIYLDVPISDDSCIAVPPLEGFVMNRLQGDYFETLLYKIFVSIDE 264

  Fly   291 HMTIAELAQMLQLELDSVKQAISFICRLGFAHRKEDLVNQTN-HSSWEGYNQQQTPDTPQITPLN 354
            |..:||||.:|:::|..||.|:|..||||||.:|..::|... |.||.        :.|.:..|.
Frog   265 HTNVAELANVLEIDLSLVKNAVSMYCRLGFALKKGQVINPDQLHPSWR--------NVPSVNRLK 321

  Fly   355 YNLHTSSSFEFDQSPKSPKTPKEREKDKDKDSSSIGYLSSDGNTSDFSFANLNTTPQERVNNSDE 419
            ..|                         |.....:.:.|::                   |.|..
Frog   322 STL-------------------------DPQKMLLSWESAE-------------------NKSPI 342

  Fly   420 QELSSELEQEDMCAPKQAAPSAAISAAVLPKSG--KRVGFLFDSTLTAFLMMGNLSPGLKNHAVT 482
            |:|:|.....|..:.:..|.::::|:..| .||  ||:.||||||||||||||||||.||:||||
Frog   343 QDLASSATDTDTNSQEDQADTSSVSSLTL-SSGHTKRIAFLFDSTLTAFLMMGNLSPNLKSHAVT 406

  Fly   483 MFEVGKLCEESLDSFLAELEQVSLLDAEGEGDVSRYFAHAVILRSTICSLRHL------------ 535
            |||||||.:|||||||.|||:|   .:.|||:..|||.||:.||:||..|||.
Frog   407 MFEVGKLSDESLDSFLVELEKV---QSTGEGEAQRYFDHALTLRNTILFLRHNKDLVAQPEQVNT 468

  Fly   536 -LPGGLDLLRLECLEGLDQQTRDRVLEKKYKFIIAASPLTASLSHTFSI--PYFGQFLRSSDVAP 597
             ||  |||||.|.|.|||..|..|||.|.|..:::.:|||..:....|.  .:.|..:  .:::.
Frog   469 GLP--LDLLRCESLLGLDPATCSRVLNKNYALLVSMAPLTNEIRPISSCTPQHIGPAI--PEISS 529

  Fly   598 MWSKLFYNHITGYGPPSLLLCRGTVLKTLPRLFLGYGKLLVNILHSDAYVLNSEN-FRSLNSQLK 661
            :|.||:..|:.|.|||||||.:||.|:.||..|..|.:||:.....|..|:.:.| ...||..|.
Frog   530 IWFKLYIYHVCGQGPPSLLLSKGTRLRKLPDPFQMYDRLLITSWGHDPGVVPTSNVLVMLNDALT 594

  Fly   662 NGCVLLQGYGIRTAGALHYESFPFQAADTRQAKWAAHRAVHK----LSSLLDLRQQCGYITFLNT 722
            :..||:||:|:...|...:..|||...:.:....:.:..|||    |...|||...|||||.||.
Frog   595 HSAVLIQGHGLHGMGETAHVPFPFDEEELQGEFSSVNMGVHKAFKILRDKLDLEHFCGYITMLNP 659

  Fly   723 GVPDLGCEDYELQVRLKPAQRQKRTSIAAPSKPNHVPTNEVTSFQLKSPDENHFAATPEHGPANE 787
            .             ||..:||  |.|.|:..|.:              ||:...|..|:...:.|
Frog   660 S-------------RLHVSQR--RLSDASDGKVD--------------PDDPSLAFRPDVNSSTE 695

  Fly   788 FTAPDCSQVLASELAKCSSRADLVSQSSVEIEEISPSVVQEEDATEEWTLLDVNFGVPLFDVDTN 852
                  |..|.||        :..:.|.::..|:|       ...::|..|::.:|:|||..:.|
Frog   696 ------SFELVSE--------ETATDSGLKAHEVS-------TVEKDWVPLELCYGIPLFASELN 739

  Fly   853 TRICEQL-VQGLCSDANLEALPAAASQAQVLFLDFVQQCLYFEDDP--------------ARQSV 902
            ..:|.:: ..|||...:|:.|..::.:..:..|:|||.   |::..              :.|..
Frog   740 QMVCRKIAAHGLCGKESLQNLLHSSRKLSLQVLNFVQS---FQEGNSSFDQLLESGSGGLSSQPS 801

  Fly   903 QAARPLPHPRINLAFENGHVCHWNGR 928
            .|...:|.|..||.|.:|.:..||||
Frog   802 PADLGVPLPSKNLIFHDGILSEWNGR 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7600	NP_648453.1	FAM91_N	32..336	CDD:291320	156/304 (51%)
CG7600	NP_648453.1	FAM91_C	452..922	CDD:291321	179/506 (35%)
fam91a1	NP_001107424.1	FAM91_N	10..312	CDD:291320	157/305 (51%)
fam91a1	NP_001107424.1	FAM91_C	375..823	CDD:291321	178/507 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	323	1.000	Domainoid score	I1209
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13388
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1299
OMA	1	1.010	-	-		QHG54137
OrthoDB	1	1.010	-	-		D164905at2759
OrthoFinder	1	1.000	-	-		FOG0005587
OrthoInspector	1	1.000	-	-		oto104798
Panther	1	1.100	-	-	LDO	PTHR28441
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080