DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and AREL1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	707	Identity:	161/707 - (22%)
Similarity:	287/707 - (40%)	Gaps:	173/707 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 MPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEE---------SMRE----------- 439
            |.||::.::    ..|.|    :|:..|.|..|||::..:|         |:|:
Human   162 MVVPSKTKI----VCHFS----TLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHEL 218

  Fly   440 ------------NESIISVTKVLKI---------------VFYAN----------ILASELERPS 467
                        .:|:.|..:..::               :.|.|          |:.||.|:
Human   219 GPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEK-- 281

  Fly   468 CRVPLEDRTEAATASGSAAVEDDLFVYNSL--------LEP-HM------PKFAEDQFEKELQVS 517
                  :..|...::...::..:.::||:.        |.| ||      |..|.|:.:::   |
Human   282 ------NIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDED---S 337

  Fly   518 AIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVD 582
            ..:|..|         |.:.:..:: :.|:|.|..:::    ..:.....:.||.|.:.|.||..
Human   338 PSECHTP---------EKVKKPKKV-YCYVSPKQFSVK----EFYLKIIPWRLYTFRVCPGTKFS 388

  Fly   583 ALYYDSRMRMYS----------------ER----YSSLHSILNNIG--------------QVGQE 613
            .|..|...::.:                ||    .:.:.|:..|||              ::.|.
Human   389 YLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQV 453

  Fly   614 DNPRPDLKLT--VRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIV 676
            ...||..|:|  |.|..|:..:|......::|   |..|...|.|..|:.:|.||..:|:|:||.
Human   454 HMKRPHSKVTLKVSRHALLESSLKATRNFSIS---DWSKNFEVVFQDEEALDWGGPRREWFELIC 515

  Fly   677 EEIFNPAFGMFIQQEETNNMWFNATPFENG----AQFTLIGIIIGLAIYNN-------VTLAVNF 730
            :.:|:....:|.:..:.|....:..|....    ..:...|.::|..:|.:       ..:...|
Human   516 KALFDTTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARF 580

  Fly   731 PMVVYRKLIGYCGTFADLSDWSPALYKS-LKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHEL 794
            ......::||....:.......|..||| :..:|:....:||.||.:. |.:.|.....||  ||
Human   581 TRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEE-KYNKSGQLDKVV--EL 642

  Fly   795 VPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG 859
            :..|....|...||..::||.:.:.|.:.::::...|.||...:..|: |..:|...|:|:|:||
Human   643 MTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPEN-LLAIFDENELELLMCG 706

  Fly   860 SREFDFVELENSTVYEGG---YTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL 921
            :.:....:.:...|..||   :.||  .::.||::|.::..|:..:||:|||||:::|.||...|
Human   707 TGDISVSDFKAHAVVVGGSWHFREK--VMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAAL 769

  Fly   922 ----RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYS-KGFGML 973
                :::.   .|....|||:|||||.|.||.|.|.|::...|..||:.. :|||||
Human   770 CPSFQIIA---APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	101/372 (27%)
		HECTc	647..970	CDD:214523	93/342 (27%)
AREL1	NP_001034568.1	Filamin	52..158
		Filamin	56..154	CDD:395505
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		9/41 (22%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		80/317 (25%)
		HECTc	486..820	CDD:214523	93/342 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810