DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and UBE3C

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_055486.2	Gene:	UBE3C / 9690	HGNCID:	16803	Length:	1083	Species:	Homo sapiens

Alignment Length:	816	Identity:	201/816 - (24%)
Similarity:	334/816 - (40%)	Gaps:	153/816 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 NSPGALNKE----QLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSS 305
            |..|||::|    .||.|:          ..:.:...|.|:|:....:.:||.|.||.|.   .|
Human   328 NYLGALSEEGLLVYLRVLQ----------TFLSQLPVSPASASCHDSASDSEEESEEADK---PS 379

  Fly   306 QSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQL------SDWVIYMRTDWERVIHCLVI- 363
            ...|      |...|..:...|..:..|::.|::::.|      |:.|.   |....|.|.|::
Human   380 SPED------GRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVF---TTMASVCHTLMVQ 435

  Fly   364 ----------CFDLATNTN---------NSVVDMDYLDRVLP--KLCQAASAMPVPAQARLARIW 407
                      .:.||.|..         :|:........::|  ::....|.|.....:|:..::
Human   436 HRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFEDSSRIIPLF 500

  Fly   408 AAHCSDQLHSLIAACQQQI---TLQVLLDEESMR---ENESIISVTKVLKIVFYANI-LASELER 465
            ....|...||||:....:.   .::|:...:|..   ..|.:|.:::.|:......| ||....:
Human   501 YLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDACLGIIKLAYPETK 565

  Fly   466 PSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAI----------- 519
            |      |.|.|..||..|..|         .....|.:..:.:.::.:|:..:
Human   566 P------EVREEYITAFQSIGV---------TTSSEMQQCIQMEQKRWIQLFKVITNLVKMLKSR 615

  Fly   520 DCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEI----GSGHANYFSFMLYAFILTPSTK 580
            |.|:...|    .|..|||...:..|.::...:.....:    ..|........|...:.:|...
Human   616 DTRRNFCP----PNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLS 676

  Fly   581 VDALYYDSRMRM------------YSERYSSLHSILNNIGQVGQEDNPRPD-LKLTVRRDQLIND 632
            |      |..|.            :.||......::....|..|.|.|..| :.:|:||:.:..|
Human   677 V------SEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYED 735

  Fly   633 ALIGLEMVAMSNPKDLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEE 692
            |   .:.::..|..||||::.|..:.     |.|||.||:.:||...:::..|||..|.|   :.
Human   736 A---YDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFF---KT 794

  Fly   693 TNNMWFNATPFENGAQ----------FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFAD 747
            ||.......|   .||          :..:|.::|.|:|.|:.:.:.|......||:   ||.||
Human   795 TNEGLLYPNP---AAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLL---GTSAD 853

  Fly   748 -----LSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHN 807
                 |:...|.:||:|..:..|: .|:||: ...|.:..:|: |:....||...|:|:.|...|
Human   854 VDIHHLASLDPEVYKNLLFLKSYE-DDVEEL-GLNFTVVNNDL-GEAQVVELKFGGKDIPVTSAN 915

  Fly   808 KELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSR-EFDFVELENS 871
            :..:::|.:|:.||..|.|...|||:|...|.....|: :|..:||::|:.|:: .....:|::.
Human   916 RIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSF 979

  Fly   872 TVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL--RLLITRHGPDSDR 934
            |.|.|||:.....|:.||.:|.....|:|.|||:|.|..:|.|:.|.|.|  ...|...|.|.:|
Human   980 TNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLER 1044

  Fly   935 LPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            |||:.||.|:|.|||:.....|..:|:.||..:.||
Human  1045 LPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	118/374 (32%)
		HECTc	647..970	CDD:214523	110/345 (32%)
UBE3C	NP_055486.2	Cis-determinant of acceptor ubiquitin-binding	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		IQ	47..64	CDD:197470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..385		11/38 (29%)
		HECTc	725..1081	CDD:238033	118/372 (32%)
		HECTc	747..1080	CDD:214523	110/345 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810