DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and BAG3

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	222	Identity:	47/222 - (21%)
Similarity:	82/222 - (36%)	Gaps:	44/222 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLD-IAGAEHSSGD 174
            ||..|:..||..|.:|...|:.:|..:..:...|.....|...|.:.:....|: :.|.|.:..:
Human   377 SPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDN 441

  Fly   175 SEPCTPTLAPVHSLDANSLIA---LYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAAS 236
            .|.        ...|...|:.   |.::..|.|              |||..|::.:|.|.....
Human   442 FEG--------KKTDKKYLMIEEYLTKELLALD--------------SVDPEGRADVRQARRDGV 484

  Fly   237 SSLQELL-------ANSPGALNKEQLRTLEGEHDKDEDSTQQV-----DEQSESAANATATAESV 289
            ..:|.:|       .:.||.:...:|:....|.|:...:..::     |:..::|.|    ||..
Human   485 RKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGN----AEDP 545

  Fly   290 ESEAEPEEEDDDVCSSQSSDTLVDLPG 316
            .:|.:..|......|:.||  :.|.||
Human   546 HTETQQPEATAAATSNPSS--MTDTPG 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		WW	21..53	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421		11/43 (26%)
		BAG	421..498	CDD:214591	17/98 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575		13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900