DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and MAGI1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	333	Identity:	74/333 - (22%)
Similarity:	114/333 - (34%)	Gaps:	95/333 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GGGEDDQ-----HLPGVSSA-------SGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGN 57
            ||.|..:     |:..:.:|       ||.....|.|  ||.:.:|  ..|:.:...|.
Human   829 GGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDG--TPVIGKS--HQLVVQLMQQA------ 883

  Fly    58 ANCSNANCASSGKV---APMTPNEVAARALQLFS--QDAQLCEAFTSEANSPQDVDMLSPNDSSS 117
            |...:.|.....||   .|.|.|||.:.|....|  |.|.|    |.|..:||
Human   884 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASL----TEEKRTPQ------------ 932

  Fly   118 SSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTL 182
             .|.:|.:|::|.|.:|:.........:.||..|..||        |:   |...|::|..
Human   933 -GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPY--------DV---EIRRGENEGF---- 981

  Fly   183 APVHSLDANSLIALYEQCRAADSYDRIC----HAIGVVF--SSVDRLGKSFIR---------SAE 232
                   ...:::...:..|..::...|    |.||.:.  |..||.||..:.         |..
Human   982 -------GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSIT 1039

  Fly   233 PAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATAT-------AESVE 290
            ..:.|.:..|:..   |.|...||.:.|    ||.|...:...:|..|..|.|       .:...
Human  1040 NKSHSDIVNLIKE---AGNTVTLRIIPG----DESSNATLLTNAEKIATITTTHTPSQQGTQETR 1097

  Fly   291 SEAEPEEE 298
            :..:|::|
Human  1098 NTTKPKQE 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	15/58 (26%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504
		WW	303..332	CDD:238122
		WW	361..390	CDD:278809
		PDZ	469..555	CDD:214570
		PDZ	640..723	CDD:214570
		MAGI_u5	722..805	CDD:293271
		PDZ_signaling	819..894	CDD:238492	16/74 (22%)
		PDZ_signaling	968..1062	CDD:238492	23/118 (19%)
		PDZ	1123..1205	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900