Protein Alignment Ube3a and HERC3

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_055421.1
• Gene: HERC3 / 8916
• HGNCID: 4876
• Length: 1050
• Species: Homo sapiens
• Alignment Length: 1090
• Identity: 265/1090 - (24%)
• Similarity: 431/1090 - (39%)
• Gaps: 242/1090 - (22%)

  Fly     6 GGEDDQHLPGVSSASGSA-------------AGAVG--GRATPEMKRSAVRSLIKRYFHQ--LQS 53
            |...|||:..|:.....:             ||:.|  |..|.| ...||..||::...|  ||.
Human    79 GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-DSVAVPRLIQKLNQQTILQV 142

  Fly    54 GCGNANC--------------SNANCASSGKVAPMTPNEVAARALQ------------------- 85
            .|||.:|              ::......||..|...:....|:|:
Human   143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL 207

  Fly    86 ---LF----SQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSS-TSTITSASTTTT------- 135
               :|    :...||..:...:..||..|.:|........|.|.. |:.:|.:....|
Human   208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272

  Fly   136 ----TSRQSQSTPAAVVVPVSSPYLTQ----------SVPQLDI-----AGAEHSSGDSEPCTPT 181
                .|...:..|..|:..:.|. :||          .||...:     .||....|....|...
Human   273 QLGHDSMNDEVNPRRVLELMGSE-VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVK 336

  Fly   182 L-APV------HS--LDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFI-----RSAE 232
            . :||      ||  |.|.           ||.:.  .|.:..:||..|   ::|:     .:..
Human   337 CPSPVKGYWAAHSGQLSAR-----------ADRFK--YHIVKQIFSGGD---QTFVLCSKYENYS 385

  Fly   233 PAASSSLQELLANSPGALNKEQLRTLEGEHDKD--EDSTQQVDEQSESAANATATAESVESEAEP 295
            ||.                  ..||:...|...  .|.|..|..|..|..|...|...|......
Human   386 PAV------------------DFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSS 432

  Fly   296 ---------EEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSS-----VIQLSDW 346
                     |::.|:...:......:||...|.:...|...|...|.|::.:|     :.|||..
Human   433 AACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSS 497

  Fly   347 ---VIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWA 408
               |..||      |:.::..|.|..::..      |:...:| |..|...:.......|...|:
Human   498 PPDVEAMR------IYLILPEFPLLQDSKY------YITLTIP-LAMAILRLDTNPSKVLDNWWS 549

  Fly   409 AHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLE 473
            ..|......|:...:..: |.:|...::.            |..|.:.|.:.:.|
Human   550 QVCPKYFMKLVNLYKGAV-LYLLRGRKTF------------LIPVLFNNYITAAL---------- 591

  Fly   474 DRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSE 538
                                          |..|..::..|:|..::       .:.||...:|.
Human   592 ------------------------------KLLEKLYKVNLKVKHVE-------YDTFYIPEISN 619

  Fly   539 NIQMHHDYLSY--KTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMY----SERY 597
            .:.:..|||.:  ....|::. .|...:..:...|.||.....|...|..|:.::|.    ....
Human   620 LVDIQEDYLMWFLHQAGMKAR-PSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANL 683

  Fly   598 SSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGI 662
            .::..:|.....:.:.    |.|.|.|||:.|:.||   |..:::.:..||||.|.|.|.||:.:
Human   684 QNVFMLLTLEPLLARS----PFLVLHVRRNNLVGDA---LRELSIHSDIDLKKPLKVIFDGEEAV 741

  Fly   663 DEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLA 727
            |.|||:||||.|:::|:.||.:|||...:::|.:||:.|.|.....|.||||..||||||:..:.
Human   742 DAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVD 806

  Fly   728 VNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQH 792
            ::||:.:|:||:.......||.:.||...:||:.:|||.|:|:||.|...|.|. .:.:|.:.|.
Human   807 LHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTIC-RESYGVIEQK 870

  Fly   793 ELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLV 857
            :|:|.|.:|.|.:.|::.||:.|.:::...::.:.:.||..||..|.....|: ||:|.|:..::
Human   871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMM 934

  Fly   858 CGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLR 922
            .|:..:::.|||.:.:|:|.|:.....::.||...|..|.|.|.|.|.|.|||.|:|:.|:..|:
Human   935 VGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ 999

  Fly   923 LLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            ::|.......:.||.:|||:|:|.||:|||:|.|..||.:|::..:||.:
Human  1000 IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	17/95 (18%)
		HECTc	620..971	CDD:238033	133/350 (38%)
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	3..341	CDD:444065	51/263 (19%)
		RCC1 2	52..101		5/21 (24%)
		RCC1 3	102..154		17/52 (33%)
		RCC1 4	156..207		5/50 (10%)
		RCC1 5	208..259		10/50 (20%)
		RCC1 6	261..311		7/50 (14%)
		RCC1	313..377	CDD:395335	17/79 (22%)
		RCC1 7	313..366		13/65 (20%)
		HECTc	702..1048	CDD:238033	133/350 (38%)