DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and RSP5

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_011051.3	Gene:	RSP5 / 856862	SGDID:	S000000927	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	489	Identity:	136/489 - (27%)
Similarity:	230/489 - (47%)	Gaps:	87/489 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 EIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNN--IGQVG-------- 611
            |:.||....|:....|:.:..:|:. ..:.|.|.:.|...|...::.:..  :.|:|
Yeast   332 ELPSGWEQRFTPEGRAYFVDHNTRT-TTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEM 395

  Fly   612 ------------------QEDNPR--------------------------PDLK-------LTVR 625
                              ..|:||                          |.|:       :.||
Yeast   396 RLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHIKVR 460

  Fly   626 RDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQ 690
            |..:..||   .:.:....|:||||:|:::|.||:|:|.||||:|||.|:..|:|||.:.:| :.
Yeast   461 RKNIFEDA---YQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLF-EY 521

  Fly   691 EETNNMWFNATPF-----ENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSD 750
            ...:|......|.     |:...|..||.::||.:::...|...|...:|:.::.......|:..
Yeast   522 SAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEG 586

  Fly   751 WSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLY 815
            ....:|.||..||:   ..::.|.:.||... .:.||:||..:|.|:|:::.|...||:.:|.||
Yeast   587 VDAEVYNSLNWMLE---NSIDGVLDLTFSAD-DERFGEVVTVDLKPDGRNIEVTDGNKKEYVELY 647

  Fly   816 SDFLLNTNIEQQFNAFRKGF-EMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYT 879
            :.:.:...:::||.||..|| |::.::  |..:|...|:|:|:.|..|.|..:.:..|.|. ||.
Yeast   648 TQWRIVDRVQEQFKAFMDGFNELIPED--LVTVFDERELELLIGGIAEIDIEDWKKHTDYR-GYQ 709

  Fly   880 EKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPT 937
            |..:.||.||..|....:|.:.:||:||||::|:||.|.|.|       |..|.:.| :..:||.
Yeast   710 ESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAG-EVQQLPK 773

  Fly   938 SHTCFNVLLLPEYSSREKLEERLMKAINYSKGFG 971
            ||||||.:.||:|...:.::::|..|:..:.|||
Yeast   774 SHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	118/370 (32%)
		HECTc	647..970	CDD:214523	110/335 (33%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	136/489 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810