DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ube3a and HUL4

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_012570.3 Gene:HUL4 / 853494 SGDID:S000003797 Length:892 Species:Saccharomyces cerevisiae


Alignment Length:935 Identity:232/935 - (24%)
Similarity:392/935 - (41%) Gaps:201/935 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 LIALYEQCRA-------ADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGAL 250
            :::|:::..|       :.|.:.:.|::.   .:.:||.||..|::|.:.::|:::...::..:.
Yeast     1 MVSLFDKLNAKKDGRDGSVSKELLSHSVA---HTKNRLPKSGRRTSERSLAASVKDGSCSNSKSN 62

  Fly   251 NKEQLRTLEGEHDKD-------------EDSTQQVDEQSESAANATATAESVESEAEPEEEDDDV 302
            .:....::.||.||.             ......:.:...||...|...:..|..:..|......
Yeast    63 KRNSSASVSGEEDKSCLISLNCLCCGVPLRFPASITKFRCSACQVTVIVKEPEINSNLESSTHIS 127

  Fly   303 CSSQSSDTLV-----DLPGLRRV-------QRLLFGCQIRAITEK-------------------- 335
            |:.:....:|     ||..|::.       :.|:|...|..:.::                    
Yeast   128 CTLEGLQMVVRRCHDDLQRLKKTGILDKERKGLIFQPVITYLLDRFHDVSILNRSFLVHDGGKNI 192

  Fly   336 --LTSSVIQ-----LSDWVIYMRTDWERVIHCLVICFDL----ATNTNNSVVDMDY--------- 380
              |...|:|     ||:  :..|..:..::.|   |.||    ..|...::..:.|         
Yeast   193 KMLNYEVLQRFYSILSN--LPTRKPYYSMLCC---CNDLLKRITINKGENLQILQYRWLLIILNI 252

  Fly   381 --------LDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESM 437
                    .||....:.:......|..:.      |..|...|.:|.....||:.       :|:
Yeast   253 PTIRTCLIRDRKSKNVFETQQIRAVSYEL------AKRCIGYLSNLSTKTSQQLI-------QSL 304

  Fly   438 RENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPH- 501
            |...:.....:|..:..|.|...|.|        |.:.....||..:...||::   .|.|..| 
Yeast   305 RRTPTDNFSYQVEILNLYINFQFSRL--------LSNELSNRTAKNNVKPEDEM---RSRLRRHH 358

  Fly   502 ------------------------------MPKFAEDQFEKELQVSA----------IDCR---K 523
                                          ..||...|:|::..:.:          .:.|   :
Yeast   359 TTGHEFLSTRPISAQSNDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFIYYVANTRRNGR 423

  Fly   524 PLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEI--------GSGHANYFSFMLYAFILTPSTK 580
            ..:.::.|||..| :.|....|:..::.:|.::::        .|.....|||..|.|||:...|
Yeast   424 GALSIQSFYNITL-DFIDYKQDFDHWRGVAQKTKMNQLIEEWGNSTTKKCFSFCKYPFILSLGIK 487

  Fly   581 VDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDL--KLTVRRDQLINDALIGLEMVAMS 643
            :..:.|:.|..|..|...:.        .:..:.....|:  |:.||||.:.:|:|..::    .
Yeast   488 ISIMEYEIRRIMEHEAEQAF--------LISLDKGKSVDVYFKIKVRRDVISHDSLRCIK----E 540

  Fly   644 NPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATP--FENG 706
            :..||.|.|.:|||.|.|||.||:.||:|.|:.:.:|||..|:||..:|::..||...|  |:..
Yeast   541 HQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKS 605

  Fly   707 -------AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLD 764
                   ..:.|.|:::||||:|:..|.:.||..:|:||.....:|.|.|:..|...::|..||:
Yeast   606 KGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLN 670

  Fly   765 YQGQDMEEVFEQTFKISYSD---VFGD------VVQHELVPNGQDVLVGQHNKELFVNLYSDFLL 820
            |...:.|:||..||:.:|.:   :..|      .|..||..||::|.:.|.||..||..:.:|.|
Yeast   671 YTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYL 735

  Fly   821 NTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSRE---FDFVELENSTVYEGGYTEKS 882
            ..:||.|:|.|..||:.|..|.....||..||:|.||||..|   |||..|.:.|.|.||:::.|
Yeast   736 EKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDS 800

  Fly   883 QYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGP-DSDRLPTSHTCFNVLL 946
            :.:..||.|:.:.....:.|||:|.|.|.|:|..|:..:...|:..|. |||.||.:|||||.:.
Yeast   801 RAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPLAHTCFNEIC 865

  Fly   947 LPEYSSREKLEERLMKAINYSKGFG 971
            |..|||::|||.:|:.|||.|:|:|
Yeast   866 LWNYSSKKKLELKLLWAINESEGYG 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166
HECTc 620..971 CDD:238033 141/374 (38%)
HECTc 647..970 CDD:214523 133/344 (39%)
HUL4NP_012570.3 HUL4 1..892 CDD:227354 232/935 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 197 1.000 Domainoid score I587
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46778
orthoMCL 1 0.900 - - OOG6_101192
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.670

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