Protein Alignment Ube3a and HUL5

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_011374.1
• Gene: HUL5 / 852736
• SGDID: S000003109
• Length: 910
• Species: Saccharomyces cerevisiae
• Alignment Length: 1021
• Identity: 219/1021 - (21%)
• Similarity: 395/1021 - (38%)
• Gaps: 228/1021 - (22%)

  Fly    57 NANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSG 121
            |.|..|....|...:......|...||.....:||                     :.:...|..
Yeast    12 NVNLGNRTRNSKKDLLEKAKRERERRAQDKLKEDA---------------------SKTIQKSIR 55

  Fly   122 SSTSTITSASTTTTTSRQSQSTPA--AVVVPVSSPYLTQSVPQLD---IAGAEHSSGDSEPCTPT 181
            ...|.:.....|.|:|:.....||  ..::...|.|..|.:.:|.   ::...:|.|:.:  ..:
Yeast    56 RHFSNVRLFKNTFTSSQLVHMIPAYGGKLIYYISQYDLQQLLKLSHNFLSSYPNSLGNRQ--LLS 118

  Fly   182 LAPVH---SLDANSLIALYEQCRAADSY-DR----ICHAIGVVFSSVDRLGKSFIRSAEPAASSS 238
            |..::   :|.|.:|..|...|...|.: |.    :|.|..:.:||..:|. ..|.:.|...||:
Yeast   119 LLKLYQDDALVAETLSDLNMDCPTVDEFLDSLSVYLCRASFLSYSSASKLA-DVIEAWEVMHSSA 182

  Fly   239 LQELLANSPGALNKE----QLRTLEGEHD--KDEDSTQQV--DEQSESAANATATAESVESEAEP 295
            ...:.:.|.|:..|.    |...:..|.:  ....:|..:  |..:::.::
Yeast   183 SISIFSISIGSYEKRPFALQFYCILAERNLLPQLINTNPILWDNMAKTYSH-------------- 233

  Fly   296 EEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQL-SDWVI--YMRTDWERV 357
                   ||.         .|.:.:.:||    |......:..||::. :|:|:  |.:...:.|
Yeast   234 -------CSK---------GGQKNIAKLL----IPNFNNHIAPSVLRSDNDYVLKFYEKAFIDEV 278

  Fly   358 IHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQA-----------------RLAR 405
            |          ..|.|.|.|.|::..:   :|..||:   |.|:                 ||:
Yeast   279 I----------ATTANYVSDEDHVKNL---MCYIASS---PNQSCKNSVLITLLSNKDFVRRLS- 326

  Fly   406 IWAAH------CSDQLHSLIAACQQQITLQVLL--DEESMRENESIISVTKVLKIVFYANILASE 462
             |...      ...:.|.|.:...|.|.:.:|:  |.|.:..| |:|.:.::.|   :.:.|...
Yeast   327 -WEFFHTKFNASKTEAHPLFSVLAQLIDMHLLISTDRELLDYN-SVIPIEELKK---FTSTLKDF 386

  Fly   463 LERPSCRVPLEDRT----EAATASGSAAVED-----------------------------DLFVY 494
            ..|....:|..:|.    ||..........|                             :|..|
Yeast   387 TFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQEY 451

  Fly   495 NSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIG 559
            ..|...|:.:.:::..|||:.   :|..:|  ||:......:.:.::   ..|.::.|.:..|:
Yeast   452 EDLYREHLEEESDEDMEKEID---LDKERP--PLKSLLLNKMKKRLK---SSLRFRKLEILLEL- 507

  Fly   560 SGHANYFSFMLYAFILTPSTKVDALYY-----DSRMRMYSERYSSLHSILNNI---GQVGQEDNP 616
                        .|.:....:||..|.     ..|:.:..:     |:::|..   ...|....
Yeast   508 ------------PFFIPFEERVDLFYMFIALDKKRLSLDDD-----HNLINMFTPWASTGMRKQ- 554

  Fly   617 RPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIF- 680
                ...:.||.::.||......:.......|....:.||..|.|||.||::|||...:.:|.|
Yeast   555 ----SAIISRDNVLEDAFNAFNSIGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFK 615

  Fly   681 NPAFGMFIQQEETNNMW-------FNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKL 738
            :|...:|    .||:.:       ::||..:   ....:|.::|..:|.:|.:.|:|.....:||
Yeast   616 DPKHELF----RTNDRYELYPSVVYDATKLK---YIWFLGKVVGKCLYEHVLIDVSFADFFLKKL 673

  Fly   739 I----GYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQ 799
            :    |:..:|:||..:...||.:|..:|:....:::.: :.||:|...:....||  :|:|||.
Yeast   674 LNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSL-DLTFEIDEPESSAKVV--DLIPNGS 735

  Fly   800 DVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSRE-F 863
            ...|.:.|..|:|...:|:.||....:..:||..|..::.....:: :|...|::||:.|.|: .
Yeast   736 KTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWME-MFNSIELQMLISGERDNI 799

  Fly   864 DFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL--RLLIT 926
            |..:|:::|.| |||.|:.|.|.|||.:::....|:|...|:|.|...:.|:.|.|.|  :..|.
Yeast   800 DLDDLKSNTEY-GGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIR 863

  Fly   927 RHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            ..|.:..||||:.||.|:|.||:|.::..|.|:|:.|||....|.:
Yeast   864 NAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDL 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	9/36 (25%)
		HECTc	620..971	CDD:238033	106/365 (29%)
		HECTc	647..970	CDD:214523	102/337 (30%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	214/998 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810