DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and TOM1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_010745.3	Gene:	TOM1 / 852068	SGDID:	S000002865	Length:	3268	Species:	Saccharomyces cerevisiae

Alignment Length:	1050	Identity:	239/1050 - (22%)
Similarity:	384/1050 - (36%)	Gaps:	316/1050 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SVPQLDIAGAEHSSGDSEPCTPTLAPVH------SLDANSLIALYEQCRAADSYDRICHAIGVVF 217
            ||.|.||..:..:..|.||...|:....      .:|...:.||.:..||.            ||
Yeast  2298 SVEQDDIQESNVTHDDHEPVYVTIQGSEVDIGGTDIDPEFMNALPDDIRAD------------VF 2350

  Fly   218 SSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANA 282
            :...|         |..|.:.|     ||...::..::         |.|..:.:.|........
Yeast  2351 AQHVR---------ERRAEARL-----NSDHNVHSREI---------DSDFLEAIPEDIREGILD 2392

  Fly   283 TATAES-----VESEAEPEEEDDDVCSS-----------QSSDTLVDLPGLRRVQRLLFGCQI-R 330
            |...|.     :.|.|:....||||.::           .|:|.....|..::..|:.|...| |
Yeast  2393 TEAEEQRMFGRIGSSADVIRADDDVSNNDEEVENGLDHGNSNDRNNADPEKKKPARIYFAPLIDR 2457

  Fly   331 AITEKLTSSVIQLSDWVIYMRTDWERVIHCLV--ICF------DLATNT-----NNSVVDMDYLD 382
            |....|..||.....::      ...:.|.|.  :|.      || .||     :..::|...|:
Yeast  2458 AGIASLMKSVFISKPYI------QREIYHELFYRLCSSKQNRNDL-MNTFLFILSEGIIDQHSLE 2515

  Fly   383 RVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVT 447
            :|...:...|..   .|:....|...:.|:    .|..|.|....||.|:|.:|.         .
Yeast  2516 KVYNIISSRAMG---HAKTTTVRQLPSDCT----PLTVANQTIEILQSLIDADSR---------L 2564

  Fly   448 KVLKIVFYANILASELERPSCRVPLED-------------------------------------R 475
            |...|..:.|::.::....|.:..|.|                                     :
Yeast  2565 KYFLIAEHDNLIVNKANNKSRKEALPDKKLRWPLWHLFSLLDRKLITDESVLMDLLTRILQVCTK 2629

  Fly   476 TEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAID-CRKPLI--PLEEFYN---- 533
            |.|..::.|...|      |...:.|:|.|.||...|.|.:..:| |...:.  .|...||
Yeast  2630 TLAVLSTSSNGKE------NLSKKFHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNIIYNLSKL 2688

  Fly   534 ---------------EALSENIQMHHDYLSYK--TLAMESEIGSGHANYFSFMLYAFILTPS--- 578
                           .::...::...|.||.:  |:....||.|.       :|..|.|..|
Yeast  2689 QGCMSIFTKHLVSLAISIMSKLKSALDGLSREVGTITTGMEINSE-------LLQKFTLPSSDQA 2746

  Fly   579 ------TKVDALYYDSR----------MRMYSER-----YSSLHSIL------------------ 604
                  |.||.||...|          ..:|.:.     :|||...|
Yeast  2747 KLLKILTTVDFLYTHKRKEEERNVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLP 2811

  Fly   605 ----------------NNIGQVGQED--------------------------------------- 614
                            |....|..||
Yeast  2812 LIESLMVVCRRSDLSQNRNTAVKYEDAKLLDFSKTRVENLFFPFTDAHKKLLNQMIRSNPKLMSG 2876

  Fly   615 -------NP----------------------RPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKK 650
                   ||                      ||.|.:||||:|:..|:...|  ...:|.:....
Yeast  2877 PFALLVKNPKVLDFDNKRYFFNAKLKSDNQERPKLPITVRREQVFLDSYRAL--FFKTNDEIKNS 2939

  Fly   651 QLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMF--IQQEETN---NMWFNATPFENGAQFT 710
            :|.:.|.||.|:|.|||::|::|::..::|||.:.:|  :..::|.   |......| |:.:.|.
Yeast  2940 KLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINP-EHLSFFK 3003

  Fly   711 LIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFE 775
            .||:|||.||.:...|..:|...||:.::|...:..|:....|..||||..:|:   .|:.::.|
Yeast  3004 FIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILE---NDITDIIE 3065

  Fly   776 QTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTD 840
            :||.:. :|.:|:.....|:..|:|::|.:.||:.:|....::.|.|::::|.:.|..||..:..
Yeast  3066 ETFSVE-TDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALIS 3129

  Fly   841 ESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLE 905
            :. |..:|..:|:|:|:.|..:.|..:.:|:|.|. .||...:.:..||..|.:..:|::.|||:
Yeast  3130 KD-LITIFDEQELELLISGLPDIDVDDWKNNTTYV-NYTATCKEVSYFWRAVRSFDAEERAKLLQ 3192

  Fly   906 FTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKA 963
            |.||:::||:.|.|.|       :..|.|....|:|||:||||||.|.||.|.|.|.|...|:.|
Yeast  3193 FVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLA 3257

  Fly   964 INYS-KGFGM 972
            ||.. :|||:
Yeast  3258 INEGHEGFGL 3267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	118/363 (33%)
		HECTc	647..970	CDD:214523	108/335 (32%)
TOM1	NP_010745.3	DUF908	92..387	CDD:399185
		DUF913	448..>683	CDD:399192
		MSCRAMM_ClfB	<1879..2061	CDD:411414
		DUF4414	2328..2357	CDD:405126	8/49 (16%)
		HUL4	2385..3268	CDD:227354	214/927 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810