Protein Alignment Ube3a and TOM1

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_010745.3
• Gene: TOM1 / 852068
• SGDID: S000002865
• Length: 3268
• Species: Saccharomyces cerevisiae
• Alignment Length: 1050
• Identity: 239/1050 - (22%)
• Similarity: 384/1050 - (36%)
• Gaps: 316/1050 - (30%)

  Fly   159 SVPQLDIAGAEHSSGDSEPCTPTLAPVH------SLDANSLIALYEQCRAADSYDRICHAIGVVF 217
            ||.|.||..:..:..|.||...|:....      .:|...:.||.:..||.            ||
Yeast  2298 SVEQDDIQESNVTHDDHEPVYVTIQGSEVDIGGTDIDPEFMNALPDDIRAD------------VF 2350

  Fly   218 SSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANA 282
            :...|         |..|.:.|     ||...::..::         |.|..:.:.|........
Yeast  2351 AQHVR---------ERRAEARL-----NSDHNVHSREI---------DSDFLEAIPEDIREGILD 2392

  Fly   283 TATAES-----VESEAEPEEEDDDVCSS-----------QSSDTLVDLPGLRRVQRLLFGCQI-R 330
            |...|.     :.|.|:....||||.::           .|:|.....|..::..|:.|...| |
Yeast  2393 TEAEEQRMFGRIGSSADVIRADDDVSNNDEEVENGLDHGNSNDRNNADPEKKKPARIYFAPLIDR 2457

  Fly   331 AITEKLTSSVIQLSDWVIYMRTDWERVIHCLV--ICF------DLATNT-----NNSVVDMDYLD 382
            |....|..||.....::      ...:.|.|.  :|.      || .||     :..::|...|:
Yeast  2458 AGIASLMKSVFISKPYI------QREIYHELFYRLCSSKQNRNDL-MNTFLFILSEGIIDQHSLE 2515

  Fly   383 RVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVT 447
            :|...:...|..   .|:....|...:.|:    .|..|.|....||.|:|.:|.         .
Yeast  2516 KVYNIISSRAMG---HAKTTTVRQLPSDCT----PLTVANQTIEILQSLIDADSR---------L 2564

  Fly   448 KVLKIVFYANILASELERPSCRVPLED-------------------------------------R 475
            |...|..:.|::.::....|.:..|.|                                     :
Yeast  2565 KYFLIAEHDNLIVNKANNKSRKEALPDKKLRWPLWHLFSLLDRKLITDESVLMDLLTRILQVCTK 2629

  Fly   476 TEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAID-CRKPLI--PLEEFYN---- 533
            |.|..::.|...|      |...:.|:|.|.||...|.|.:..:| |...:.  .|...||
Yeast  2630 TLAVLSTSSNGKE------NLSKKFHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNIIYNLSKL 2688

  Fly   534 ---------------EALSENIQMHHDYLSYK--TLAMESEIGSGHANYFSFMLYAFILTPS--- 578
                           .::...::...|.||.:  |:....||.|.       :|..|.|..|
Yeast  2689 QGCMSIFTKHLVSLAISIMSKLKSALDGLSREVGTITTGMEINSE-------LLQKFTLPSSDQA 2746

  Fly   579 ------TKVDALYYDSR----------MRMYSER-----YSSLHSIL------------------ 604
                  |.||.||...|          ..:|.:.     :|||...|
Yeast  2747 KLLKILTTVDFLYTHKRKEEERNVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLP 2811

  Fly   605 ----------------NNIGQVGQED--------------------------------------- 614
                            |....|..||
Yeast  2812 LIESLMVVCRRSDLSQNRNTAVKYEDAKLLDFSKTRVENLFFPFTDAHKKLLNQMIRSNPKLMSG 2876

  Fly   615 -------NP----------------------RPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKK 650
                   ||                      ||.|.:||||:|:..|:...|  ...:|.:....
Yeast  2877 PFALLVKNPKVLDFDNKRYFFNAKLKSDNQERPKLPITVRREQVFLDSYRAL--FFKTNDEIKNS 2939

  Fly   651 QLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMF--IQQEETN---NMWFNATPFENGAQFT 710
            :|.:.|.||.|:|.|||::|::|::..::|||.:.:|  :..::|.   |......| |:.:.|.
Yeast  2940 KLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINP-EHLSFFK 3003

  Fly   711 LIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFE 775
            .||:|||.||.:...|..:|...||:.::|...:..|:....|..||||..:|:   .|:.::.|
Yeast  3004 FIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILE---NDITDIIE 3065

  Fly   776 QTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTD 840
            :||.:. :|.:|:.....|:..|:|::|.:.||:.:|....::.|.|::::|.:.|..||..:..
Yeast  3066 ETFSVE-TDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALIS 3129

  Fly   841 ESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLE 905
            :. |..:|..:|:|:|:.|..:.|..:.:|:|.|. .||...:.:..||..|.:..:|::.|||:
Yeast  3130 KD-LITIFDEQELELLISGLPDIDVDDWKNNTTYV-NYTATCKEVSYFWRAVRSFDAEERAKLLQ 3192

  Fly   906 FTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKA 963
            |.||:::||:.|.|.|       :..|.|....|:|||:||||||.|.||.|.|.|.|...|:.|
Yeast  3193 FVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLA 3257

  Fly   964 INYS-KGFGM 972
            ||.. :|||:
Yeast  3258 INEGHEGFGL 3267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173
		HECTc	620..971	CDD:238033	118/363 (33%)
TOM1	NP_010745.3	DUF908	92..387	CDD:428721
		DUF913	448..>683	CDD:461803
		MSCRAMM_ClfA	<1865..2104	CDD:468110
		UBM	2327..2359	CDD:464159	9/52 (17%)
		UBM	2367..2399	CDD:464159	5/40 (13%)
		HUL4	2385..3268	CDD:227354	214/927 (23%)