DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ube3a and Nedd4l

DIOPT Version :9

Sequence 1:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster
Sequence 2:XP_036017204.1 Gene:Nedd4l / 83814 MGIID:1933754 Length:1261 Species:Mus musculus


Alignment Length:1025 Identity:225/1025 - (21%)
Similarity:366/1025 - (35%) Gaps:359/1025 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GGGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSG 69
            ||||..:....:|.....|..:: ..|.|....|.|                            .
Mouse   533 GGGEGPEPWETISEEMNMAGDSL-SLALPPPPASPV----------------------------S 568

  Fly    70 KVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTT 134
            :.:|...:|..:|.||:           |.::|..|         .||......:|.:.|.|.|.
Mouse   569 RTSPQELSEEVSRRLQI-----------TPDSNGEQ---------FSSLIQREPSSRLRSCSVTD 613

  Fly   135 TTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQ 199
            |.:.|      |.:.|.|:|  |:......:.|.|.|       ||::|.||:  ...|.:.:|:
Mouse   614 TVAEQ------AHLPPPSTP--TRRARSSTVTGGEES-------TPSVAYVHT--TPGLPSGWEE 661

  Fly   200 CRAADSYDRICHAIGVVFSSVDRLGKSF---------------IRSAEPAASSSLQELLANSPGA 249
            .:                   |..|:::               ::.||..||.|    ..||...
Mouse   662 RK-------------------DAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS----ATNSNNH 703

  Fly   250 LNKEQLR--------------TLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDD 300
            |.:.|:|              .|||.  ||....:.|   .::.:|..:...|..:..:|:    
Mouse   704 LVEPQIRRPRSLSSPTVTLSAPLEGA--KDSPIRRAV---KDTLSNPQSPQPSPYNSPKPQ---- 759

  Fly   301 DVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICF 365
                                             .|:|.|         ::...||..|......|
Mouse   760 ---------------------------------HKVTQS---------FLPPGWEMRIAPNGRPF 782

  Fly   366 DLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITL-- 428
            .:..||..:..:.       |:|     ..||..:::     |:...:.|..|....:::|.|  
Mouse   783 FIDHNTKTTTWED-------PRL-----KFPVHMRSK-----ASLNPNDLGPLPPGWEERIHLDG 830

  Fly   429 ---------QVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGS 484
                     |||..|...||:                             |||            
Mouse   831 RTFYIDHSSQVLCGENDTRES-----------------------------VPL------------ 854

  Fly   485 AAVEDDLFVYNSLLEPHMPKFAEDQFE-KELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLS 548
                     |:|.:         .|:| ..||..||  ..|.:|        .|...:..:||..
Mouse   855 ---------YDSKI---------TQWEDPRLQNPAI--TGPAVP--------YSREFKQKYDYFR 891

  Fly   549 YKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQE 613
             |.|...::|    .|.|...|:                 |..::.|.|..:.|:          
Mouse   892 -KKLKKPADI----PNRFEMKLH-----------------RNNIFEESYRRIMSV---------- 924

  Fly   614 DNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEE 678
              .|||:                           ||.:|.:||..|:|:|.|||::|:|.|:.:|
Mouse   925 --KRPDV---------------------------LKARLWIEFESEKGLDYGGVAREWFFLLSKE 960

  Fly   679 IFNPAFGMFIQQEETNNMWFNATPFENG-------AQFTLIGIIIGLAIYNNVTLAVNFPMVVYR 736
            :|||.:|:| :...|:|......| .:|       :.||.||.:.|||:::...|...|....|:
Mouse   961 MFNPYYGLF-EYSATDNYTLQINP-NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 1023

  Fly   737 KLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVF---EQTFKISYSDVFGDVVQHELVPNG 798
            .::|...|..|:.......|.|||.:|:....:::.:|   |:.        ||...|.:|.|||
Mouse  1024 MMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN--------FGQTYQVDLKPNG 1080

  Fly   799 QDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKL--LFRPEEIEMLVCGSR 861
            .:::|...||..:::|...:.....:::|.|||.:||   |:..|:.|  :|...|:|:|:||..
Mouse  1081 SEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF---TELLPIDLIKIFDENELELLMCGLG 1142

  Fly   862 EFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL----- 921
            :.|..:....::|:.||......||.||..|..|.:|.:.:||:|.||::|||:.|...|     
Mouse  1143 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 1207

  Fly   922 -RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
             :|.........::||.:|||||.|.||.|.:.|.|.|:|:.|:..::||
Mouse  1208 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 1257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 6/53 (11%)
HECTc 620..971 CDD:238033 110/369 (30%)
HECTc 647..970 CDD:214523 108/340 (32%)
Nedd4lXP_036017204.1 PHA03378 <107..318 CDD:223065
C2 <367..420 CDD:417471
WW 465..491 CDD:395320
WW 655..684 CDD:395320 4/47 (9%)
WW 768..798 CDD:238122 7/36 (19%)
WW 817..867 CDD:197736 16/108 (15%)
HECTc 928..1257 CDD:214523 109/368 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.