Protein Alignment Ube3a and Nedd4l

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_036017204.1
• Gene: Nedd4l / 83814
• MGIID: 1933754
• Length: 1261
• Species: Mus musculus
• Alignment Length: 1025
• Identity: 225/1025 - (21%)
• Similarity: 366/1025 - (35%)
• Gaps: 359/1025 - (35%)

  Fly     5 GGGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSG 69
            ||||..:....:|.....|..:: ..|.|....|.|                            .
Mouse   533 GGGEGPEPWETISEEMNMAGDSL-SLALPPPPASPV----------------------------S 568

  Fly    70 KVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTT 134
            :.:|...:|..:|.||:           |.::|..|         .||......:|.:.|.|.|.
Mouse   569 RTSPQELSEEVSRRLQI-----------TPDSNGEQ---------FSSLIQREPSSRLRSCSVTD 613

  Fly   135 TTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQ 199
            |.:.|      |.:.|.|:|  |:......:.|.|.|       ||::|.||:  ...|.:.:|:
Mouse   614 TVAEQ------AHLPPPSTP--TRRARSSTVTGGEES-------TPSVAYVHT--TPGLPSGWEE 661

  Fly   200 CRAADSYDRICHAIGVVFSSVDRLGKSF---------------IRSAEPAASSSLQELLANSPGA 249
            .:                   |..|:::               ::.||..||.|    ..||...
Mouse   662 RK-------------------DAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS----ATNSNNH 703

  Fly   250 LNKEQLR--------------TLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDD 300
            |.:.|:|              .|||.  ||....:.|   .::.:|..:...|..:..:|:
Mouse   704 LVEPQIRRPRSLSSPTVTLSAPLEGA--KDSPIRRAV---KDTLSNPQSPQPSPYNSPKPQ---- 759

  Fly   301 DVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICF 365
                                             .|:|.|         ::...||..|......|
Mouse   760 ---------------------------------HKVTQS---------FLPPGWEMRIAPNGRPF 782

  Fly   366 DLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITL-- 428
            .:..||..:..:.       |:|     ..||..:::     |:...:.|..|....:::|.|
Mouse   783 FIDHNTKTTTWED-------PRL-----KFPVHMRSK-----ASLNPNDLGPLPPGWEERIHLDG 830

  Fly   429 ---------QVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGS 484
                     |||..|...||:                             |||
Mouse   831 RTFYIDHSSQVLCGENDTRES-----------------------------VPL------------ 854

  Fly   485 AAVEDDLFVYNSLLEPHMPKFAEDQFE-KELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLS 548
                     |:|.:         .|:| ..||..||  ..|.:|        .|...:..:||..
Mouse   855 ---------YDSKI---------TQWEDPRLQNPAI--TGPAVP--------YSREFKQKYDYFR 891

  Fly   549 YKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQE 613
             |.|...::|    .|.|...|:                 |..::.|.|..:.|:
Mouse   892 -KKLKKPADI----PNRFEMKLH-----------------RNNIFEESYRRIMSV---------- 924

  Fly   614 DNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEE 678
              .|||:                           ||.:|.:||..|:|:|.|||::|:|.|:.:|
Mouse   925 --KRPDV---------------------------LKARLWIEFESEKGLDYGGVAREWFFLLSKE 960

  Fly   679 IFNPAFGMFIQQEETNNMWFNATPFENG-------AQFTLIGIIIGLAIYNNVTLAVNFPMVVYR 736
            :|||.:|:| :...|:|......| .:|       :.||.||.:.|||:::...|...|....|:
Mouse   961 MFNPYYGLF-EYSATDNYTLQINP-NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 1023

  Fly   737 KLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVF---EQTFKISYSDVFGDVVQHELVPNG 798
            .::|...|..|:.......|.|||.:|:....:::.:|   |:.        ||...|.:|.|||
Mouse  1024 MMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN--------FGQTYQVDLKPNG 1080

  Fly   799 QDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKL--LFRPEEIEMLVCGSR 861
            .:::|...||..:::|...:.....:::|.|||.:||   |:..|:.|  :|...|:|:|:||..
Mouse  1081 SEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF---TELLPIDLIKIFDENELELLMCGLG 1142

  Fly   862 EFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL----- 921
            :.|..:....::|:.||......||.||..|..|.:|.:.:||:|.||::|||:.|...|
Mouse  1143 DVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 1207

  Fly   922 -RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
             :|.........::||.:|||||.|.||.|.:.|.|.|:|:.|:..::||
Mouse  1208 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	6/53 (11%)
		HECTc	620..971	CDD:238033	110/369 (30%)
Nedd4l	XP_036017204.1	C2	<367..420	CDD:472691
		WW	465..491	CDD:459800
		WW	655..684	CDD:459800	4/47 (9%)
		WW	768..798	CDD:238122	7/36 (19%)
		WW	817..867	CDD:197736	16/108 (15%)
		HECTc	928..1257	CDD:214523	109/368 (30%)