DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and ITCH

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001244066.1	Gene:	ITCH / 83737	HGNCID:	13890	Length:	903	Species:	Homo sapiens

Alignment Length:	366	Identity:	116/366 - (31%)
Similarity:	199/366 - (54%)	Gaps:	26/366 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAF 684
            :|:||.|..|..|:   .:.:...:|:||:::|.|.|.||:|:|.|||::|:|.|:..|:.||.:
Human   548 IKITVTRKTLFEDS---FQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 609

  Fly   685 GMFIQQEETNN-MWFNATPFENG---AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTF 745
            .:|....:.|. :..|...:.|.   ..|..||..|.:|:::...:...|.:..|::::......
Human   610 CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGL 674

  Fly   746 ADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKE 809
            .||....|..|.||   :..:..::||. .|..|.:. .::.|::..|:|.|||.::||.:.|||
Human   675 KDLESIDPEFYNSL---IWVKENNIEECDLEMYFSVD-KEILGEIKSHDLKPNGGNILVTEENKE 735

  Fly   810 LFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVY 874
            .::.:.:::.|:..:|:|..||.:||..:..:..|: .|..:|:|:|:||.:|.|..:.:...:|
Human   736 EYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQ-YFDAKELEVLLCGMQEIDLNDWQRHAIY 799

  Fly   875 EGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPD-------- 931
            . .|...|:.|..||..|..:.:|.:.:||:|.||:.|:||||...   |:..:||.
Human   800 R-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD---LMGSNGPQKFCIEKVG 860

  Fly   932 -SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFG 971
             .:.||.||||||.|.||.|.|.|:|:|:|:.||..::|||
Human   861 KENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	114/364 (31%)
		HECTc	647..970	CDD:214523	106/336 (32%)
ITCH	NP_001244066.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..301
		WW	328..357	CDD:306827
		HUL4	<359..903	CDD:227354	116/366 (32%)
		Required for interaction with FYN. /evidence=ECO:0000269\|PubMed:16387660	395..471
		MAP kinase docking site. /evidence=ECO:0000250	574..583		3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910