Protein Alignment Ube3a and ube3a

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001007319.1
• Gene: ube3a / 792398
• ZFINID: ZDB-GENE-041114-190
• Length: 857
• Species: Danio rerio
• Alignment Length: 995
• Identity: 397/995 - (39%)
• Similarity: 556/995 - (55%)
• Gaps: 194/995 - (19%)

  Fly    35 MKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTS 99
            |||:|.:.||:||:|||..||||..|:|..|.||.....|..|..|.:||:|:..:|:||
Zfish     1 MKRAAAKHLIERYYHQLTEGCGNEACTNEACGSSPGFQRMDNNAAAIKALELYKNNAKLC----- 60

  Fly   100 EANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLD 164
                          |...|..|:|:                                  :.|:..
Zfish    61 --------------DPHPSKKGASS----------------------------------AFPENS 77

  Fly   165 IAGAEHSSG---------DSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSV 220
            ..||.:.|.         |..|.......::.|..:.:..:...|...:.|..:...||.||||.
Zfish    78 AKGAHNFSACSNGKMNHKDLPPTREDFRDLNFLTEDKVYEILSICSETEDYSPLIRVIGRVFSSA 142

  Fly   221 DRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATAT 285
            :.|.:||.::.:.                 .||:|::|:.   ||||.    ||..:..|:.::|
Zfish   143 ESLVQSFRKAKQH-----------------TKEELKSLQA---KDEDK----DEDEKETASGSST 183

  Fly   286 AESVESEAEPEEEDDDVCSSQSSDTL---------VDLPGLRRV-QRLLFGCQIRAITEKLTSSV 340
            |..||.||.....|.   ||...:.:         ||:..:||| .|||       ..||:.::.
Zfish   184 AMEVEPEASASSGDG---SSHGENNVQKLGPVEVSVDIDAVRRVYDRLL-------SNEKIEAAF 238

  Fly   341 IQLSDWVIYMRTDWE-------------RVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAA 392
            :..   ::|:..:.|             ..::..:|..:     |:::...:||:..||:.|:|.
Zfish   239 LNA---LVYLSPNVECDLTYHNVYAADPNYLNVFIIVME-----NSNLHSPEYLEIALPQFCKAM 295

  Fly   393 SAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEES----MRENESIISVTKVLKIV 453
            |.:|:||.|:|||:|:.:..||:..|:...||.||..|:.:|.|    :.|::.:::.||.||||
Zfish   296 SKLPLPALAKLARLWSQYGVDQIRRLVETFQQLITYTVISNEFSSDNLVNEDDGVVAATKCLKIV 360

  Fly   454 FYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAE----------- 507
            :|||:|..:|:        .|..|          |||        :..:|:.:|
Zfish   361 YYANVLGGDLD--------TDHNE----------EDD--------DEPIPESSELTLQELLGEER 399

  Fly   508 --------DQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHAN 564
                    |..|.|:.:.|.||||||||.|||.||.|:|.::|..||..:|   :|:|      :
Zfish   400 RNKKGPRVDPLETEMGIRASDCRKPLIPFEEFINEPLNEVLEMDKDYTFFK---VETE------S 455

  Fly   565 YFSFMLYAFILTPSTKVDALYYDSRMRMYSE-RYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQ 628
            .||||...|||...||...||||:|:||||| |.::|:|::.     ||:.||.  |:|.||||.
Zfish   456 KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITALYSLVQ-----GQQLNPY--LRLKVRRDH 513

  Fly   629 LINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEET 693
            :|:|||:.|||:||.||.||||||.|||.||||:||||||||||||:|||||||..|||...|.|
Zfish   514 IIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEST 578

  Fly   694 NNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKS 758
            ...|||.:.|||..|||||||::|||||||..|.|:||||:||||:|..|||.||:|..|.|::|
Zfish   579 KLFWFNPSSFENEGQFTLIGIVLGLAIYNNCILDVHFPMVIYRKLMGKKGTFRDLADSHPVLFQS 643

  Fly   759 LKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTN 823
            ||.:::|:| ::||....||:||.:|:||:.:.::|..:|..:.|...|::.||.||::::||.:
Zfish   644 LKDLMEYEG-NVEEDMMITFQISQTDLFGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKS 707

  Fly   824 IEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDF 888
            :|:||.|||:||.|||:|||||.||||||||:|:||||..||..||.||.|:|||.:.|:.|:||
Zfish   708 VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDF 772

  Fly   889 WSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSR 953
            |..||:...|.|...|:||||:.|.|||||..|:::|.::|||||||||||||||||||||||:.
Zfish   773 WETVHSFEQEKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDSDRLPTSHTCFNVLLLPEYSTV 837

  Fly   954 EKLEERLMKAINYSKGFGML 973
            |||:|||:|||.|:||||||
Zfish   838 EKLKERLLKAITYAKGFGML 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	23/53 (43%)
		HECTc	620..971	CDD:238033	213/350 (61%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:465173	23/53 (43%)
		HECTc	505..855	CDD:238033	213/350 (61%)