Protein Alignment Ube3a and ube3b

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001072875.1
• Gene: ube3b / 780337
• XenbaseID: XB-GENE-1010563
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 767
• Identity: 186/767 - (24%)
• Similarity: 310/767 - (40%)
• Gaps: 193/767 - (25%)

  Fly   293 AEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLF--GCQIRAIT-----EKLTSSVIQLSDWVIYM 350
            ||.::....|..|.||....:|| ::.:.:..|  ...:|.|.     :|:.|..:|
 Frog   407 AENQDVSVPVSQSSSSSPQNNLP-MKNLFKRAFQKSASVRHILKPIGGKKVDSPEVQ-------- 462

  Fly   351 RTDWERVIHCLVICFDLATNTNNSV-----VDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAH 410
                 :|.:..|: :.:|..|...:     ..:.|||.:||||                  ||..
 Frog   463 -----KVCNICVL-YQMALTTLTQIRLQILTGLTYLDDLLPKL------------------WAFI 503

  Fly   411 C----------------SDQ------LHSLIAACQQQITLQVLLDEESMREN------ESIISVT 447
            |                ||.      |..|:..|.....|..:||:..:.|.      |.:::::
 Frog   504 CELGPQGGLKLFLECLSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTIS 568

  Fly   448 KVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLF--VYNSLLEPHMPKFAEDQF 510
            ..|....:..|....||               .|.|...   :||  |:..|:.         .:
 Frog   569 SFLNSFVFKMIWDGLLE---------------NAKGETL---ELFHSVHGWLMV---------LY 606

  Fly   511 EKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFIL 575
            |:       |||:...|.:.:..:.|...       |.::.|..|.:             .|.:|
 Frog   607 ER-------DCRRRFAPEDHWLRKDLKPT-------LLFQELDKERK-------------RAQLL 644

  Fly   576 TPSTKVDALYYDSRMRMYSERYSSLHSIL----NNIGQVGQEDNPRPDL-KLTVRRDQLINDALI 635
                    |.|...:..:..|.....:|:    ..:|.| :.:...|.: .:|:||.:::.|
 Frog   645 --------LQYIPHVIPHKNRVLLFRNIVTKEKEKLGLV-ETNTASPHVTHITIRRSRMLED--- 697

  Fly   636 GLEMVAMSNPKDLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNN 695
            |.:.:...:...:|..:.|:||.     |.|||:.||.|||.:.|::.:|:||..:|......:.
 Frog   698 GYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDR 762

  Fly   696 MWFNATPF--ENGAQ-FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIG-YCGTFADLSDWSPAL- 755
            ::.:.|.:  ||..| |..:|.::|.|:|..:.:.|.|......:|:| :...|....|..|:|
 Frog   763 LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLD 827

  Fly   756 ---YKSLKSMLDYQGQDMEEVFEQTFKISY-SDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYS 816
               ||:|.|:..|.|    ::.:....:|| .||.|.:|.|||||.|:.:.|...||..:::|.:
 Frog   828 SEFYKNLTSIKRYDG----DISDLGLTLSYDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMA 888

  Fly   817 DFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG-SREFDFVELENSTVYEGGYTE 880
            .|.::|.|:.|..||..||..:.....:::...| |::.|:.| :.|.|..:|:..|||.||:..
 Frog   889 HFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAP-ELQRLISGDNAEIDLDDLKKHTVYYGGFHG 952

  Fly   881 KSQYIQDFWSIV-HAMPSEDKHKLLEFTTGSARVPVGG---------LKC--------------- 920
            ..:.|...|.|: :...||:|...|:|.|..:|.|:.|         ::|
 Frog   953 SHRVIIWLWDILANDFSSEEKAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGS 1017

  Fly   921 -LRLLIT-RHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
             ||...| |......|||||.||||:|.||.||.:..|.|:|..||:.:.||
 Frog  1018 VLRGFFTIRKKEPGGRLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGF 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173
		HECTc	620..971	CDD:238033	120/394 (30%)
ube3b	NP_001072875.1	IQ	28..50	CDD:197470
		HECTc	686..1070	CDD:238033	120/392 (31%)