DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and itch

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001072737.1	Gene:	itch / 780194	XenbaseID:	XB-GENE-976485	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	366	Identity:	118/366 - (32%)
Similarity:	199/366 - (54%)	Gaps:	26/366 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAF 684
            :|:||.|..|..|:   .:.:...|.:||:::|.:...||:|:|.|||::|:|.|:..|:.||.:
Frog   498 VKITVNRKTLFEDS---FQQIMSFNAQDLRRRLWIIIPGEEGLDYGGVAREWFFLLSHEVMNPMY 559

  Fly   685 GMFIQQEETNN-MWFNATPFENG---AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTF 745
            .:|....:.|. :..|...:.|.   ..|..||..|.:|:::...:...|.:..|::::......
Frog   560 CLFEYAGKDNYCLQINPASYINPDHLRYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGL 624

  Fly   746 ADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKE 809
            .||....|..|.||..:.|   .::||. .|..|.:. .::.|||..|:|.|:|.::.|.:.|||
Frog   625 KDLESVDPEFYNSLIWIKD---NNIEECGLEMFFSVD-KEILGDVKSHDLKPDGSNIQVTEENKE 685

  Fly   810 LFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVY 874
            .::.|.:::.|:..:|:|..||.:||..:..:..|: .|..:|:|:|:||.:|.|..:.:.:|:|
Frog   686 EYIRLVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQ-YFDAKELEVLLCGMQEIDLNDWQRNTIY 749

  Fly   875 EGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPD-------- 931
            . .||..|:.|..||..|..:.:|.:.:||:|.||:.|:||||...   |:..:||.
Frog   750 R-HYTRTSKQIIWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD---LMGSNGPQKFCIEKVG 810

  Fly   932 -SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFG 971
             .:.||.||||||.|.||.|.|.|:|:|:|:.||..::|||
Frog   811 KENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	116/364 (32%)
		HECTc	647..970	CDD:214523	108/336 (32%)
itch	NP_001072737.1	C2_E3_ubiquitin_ligase	17..137	CDD:175988
		WW	279..308	CDD:306827
		HUL4	<310..853	CDD:227354	118/366 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910