DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and ube3c

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001072518.1	Gene:	ube3c / 779973	XenbaseID:	XB-GENE-1011935	Length:	1082	Species:	Xenopus tropicalis

Alignment Length:	852	Identity:	184/852 - (21%)
Similarity:	326/852 - (38%)	Gaps:	239/852 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 LQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDD--- 300
            |.:|..:|.|. |.::|.:  ...|.|:|.|:.:....:...:.....|....:.:.:::.:
Frog   347 LSQLPVSSSGT-NHQELNS--DSEDDDDDITKMLTTAGDGKISVQYMTEECLKKLDTKQQTNLLL 408

  Fly   301 -----------------DVCSSQSSDTLVDLPGLRRVQRLLFGCQ--------IRAITEK-LTSS 339
                             .:|.:......:.:|.:|.:..|.|..:        |.::|.| :|.|
Frog   409 NMVWRDSANEEVFTLMASICHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWYLISSMTTKMITGS 473

  Fly   340 VIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLA 404
            .:.|                       |...:..|.:.::..:|::|                |.
Frog   474 RVPL-----------------------LQVISRGSPMSLEDSNRIIP----------------LF 499

  Fly   405 RIWAAHCSDQLHSL-----------IAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANI 458
            .::::..|..|.|:           :|..:|...:...||:        :|.:::.|:......|
Frog   500 YLFSSLFSHSLISVHDNEFFGDPREVAGQRQSSMMPFTLDQ--------LIVLSRCLRDACLGII 556

  Fly   459 -LASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAI--- 519
             ||....:|      |.|.|...|..|..|..:         ..|.|..:.:.::.:|:..:
Frog   557 KLAYPETKP------EVREEYMAAFRSIGVTTN---------AEMQKQIQAEQKRWIQLFKVITN 606

  Fly   520 --------DCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILT 576
                    |.|:...|...:.:|  .|||:
Frog   607 LVKMLKSRDARRNFCPFNHWLSE--QENIK----------------------------------- 634

  Fly   577 PSTKVDALYYDS-----RMRM---------------------------------------YSERY 597
             :.||..||..|     |:|.                                       :.||.
Frog   635 -ADKVTQLYVPSARHVWRVRRMGRIGPLQSTLDVGLEPAPLSVSEERQLAILTELPFVVPFEERV 698

  Fly   598 SSLHSILNNIGQVGQEDNPRPD-LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVG--- 658
            .....::....|..|.|.|..| :.:|:||:.:..||   .:.::..|..||||::.|..:.
Frog   699 KIFQRLIYADKQEVQGDGPFIDGINVTIRRNYIYEDA---YDKLSPENEPDLKKRIRVHLLNTHG 760

  Fly   659 --EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQ----------FTL 711
              |.|||.||:.:||...:::..|||..|.|   :.||.......|   .||          :..
Frog   761 LDEAGIDGGGIFREFLNELLKSGFNPNQGFF---KTTNEGLLYPNP---AAQMLVGDSFARHYYF 819

  Fly   712 IGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFAD-----LSDWSPALYKSLKSMLDYQGQDME 771
            :|.::|.|:|.|:.:.:.|......||:   ||.||     |:...|.:|::|..:..|: .|:|
Frog   820 LGRMLGKALYENMLVELPFASFFLSKLL---GTSADVDIHHLASLDPEMYRNLLFLKSYE-DDVE 880

  Fly   772 EVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFE 836
            |: ...|.:..:|: |:....||...|:|:.|...|:..:::|.:|:.||..|.....|||:|..
Frog   881 EL-GLNFTVVNNDL-GEAQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHCLAFRQGLA 943

  Fly   837 MVTDESPLKLLFRPEEIEMLVCGSR-EFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDK 900
            .|.:...|: :|..:|:::|:.|:: .....:|::.|.|.|||:.....|:.||.:|.....|:|
Frog   944 NVVNLEWLR-MFDQQELQVLISGAQVPICLDDLKSFTNYSGGYSADHAVIKIFWRVVENFTDEEK 1007

  Fly   901 HKLLEFTTGSARVPVGGLKCL--RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKA 963
            .|||:|.|..:|.|:.|.|.|  ...|...|.|.:||||:.||.|:|.|||:.....::.:|:.|
Frog  1008 RKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEHLMKSKLLYA 1072

  Fly   964 INYSKGF 970
            |..:.||
Frog  1073 IECAAGF 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	114/374 (30%)
		HECTc	647..970	CDD:214523	106/345 (31%)
ube3c	NP_001072518.1	IQ	47..64	CDD:197470
		HECTc	724..1080	CDD:238033	114/372 (31%)
		HECTc	746..1079	CDD:214523	106/345 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910