Protein Alignment Ube3a and Smurf1

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_006504947.1
• Gene: Smurf1 / 75788
• MGIID: 1923038
• Length: 757
• Species: Mus musculus
• Alignment Length: 614
• Identity: 155/614 - (25%)
• Similarity: 269/614 - (43%)
• Gaps: 163/614 - (26%)

  Fly   458 ILASELERPSCRVPL-------------------EDRT---------------------EAATAS 482
            :|...|..|..|.||                   |.||                     ...:..
Mouse   207 LLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPL 271

  Fly   483 GSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRK--PLIPLEEFYNEALSENIQMHHD 545
            |:....|:.|:|..||:.|.        .:...:::::|.:  ||.|..|..:
Mouse   272 GTIPGGDEAFLYEFLLQGHT--------SEPRDLNSVNCDELGPLPPGWEVRS------------ 316

  Fly   546 YLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILN----- 605
                                          |.|.::..:.:::|...:::  ..||.|:|
Mouse   317 ------------------------------TVSGRIYFVDHNNRTTQFTD--PRLHHIMNHQCQL 349

  Fly   606 ----------NIGQVGQEDNP---------------RPDL----------KLTVRRDQLINDALI 635
                      :.|.|..|:.|               |.:|          ::.|.|:::..::
Mouse   350 KEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEES-- 412

  Fly   636 GLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMW--- 697
             ...:....||||||:|:|:|.||:|:|.|||::|:..|:..|:.||.:|:|  |..|:|::
Mouse   413 -YRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLF--QYSTDNIYTLQ 474

  Fly   698 ----FNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKS 758
                .:..| ::.:.|..:|.|:|||:::...:...|.:..|::|:|.....:||....|.|:||
Mouse   475 INPDSSINP-DHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKS 538

  Fly   759 LKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTN 823
            |..:|:   .|:..|.:.||.:.: :.||.::||||.|||::|.|.:.||:.:|.||.::.....
Mouse   539 LVWILE---NDITPVLDHTFCVEH-NAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRG 599

  Fly   824 IEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDF 888
            ||.||.|.:|||..:..:..|| .|..:|:|:::.|..:.|..:.:::|..:....: |..::.|
Mouse   600 IEAQFLALQKGFNELIPQHLLK-PFDQKELELIIGGLDKIDLNDWKSNTRLKHCVAD-SNIVRWF 662

  Fly   889 WSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGP----------DSDRLPTSHTCFN 943
            |..|.....|.:.:||:|.|||.|||:.|.|.|:......||          ::|.||.:|||||
Mouse   663 WQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFN 727

  Fly   944 VLLLPEYSSREKLEERLMKAINYSKGFGM 972
            .:.:|.|.|.|||.|:|:.|:..:.||.:
Mouse   728 RIDIPPYESYEKLYEKLLTAVEETCGFAV 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	121/377 (32%)
		HECTc	647..970	CDD:214523	115/339 (34%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028
		WW	236..267	CDD:197736	3/30 (10%)
		WW	307..339	CDD:197736	7/75 (9%)
		HECTc	399..754	CDD:238033	119/366 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810