Protein Alignment Ube3a and hace1

DIOPT Version :10

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_012818577.2
• Gene: hace1 / 734146
• XenbaseID: XB-GENE-5757512
• Length: 1012
• Species: Xenopus tropicalis
• Alignment Length: 1042
• Identity: 235/1042 - (22%)
• Similarity: 391/1042 - (37%)
• Gaps: 275/1042 - (26%)

  Fly    44 IKRYFHQLQSGCGNANC--------SNANCASSGKVAPMTPNEVAAR--------ALQLFSQDAQ 92
            :||....:.:.||:..|        ::.|...   ::..||..:|||        .|..::.|..
 Frog   132 VKRSLLHIAANCGSVECLVLLLKRGADPNYQD---ISGCTPLHLAARNGQKKCMSKLLEYNADVN 193

  Fly    93 LC--EAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPY 155
            :|  |..|:       :..|:.|        ..|..:..
 Frog   194 ICNNEGLTA-------IHWLAVN--------GRTELLHD-------------------------- 217

  Fly   156 LTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSV 220
            |.|.|..:|:.                      ||....||:..|:.......:|    ::.|..
 Frog   218 LVQHVTNVDVE----------------------DAMGQTALHVACQNGHKTTVLC----LLDSGA 256

  Fly   221 DRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEG-EHDKDEDSTQQVDEQSESAANATA 284
            | :.:..:..|.|.       ..|.|.|..:..|:..|.| ::..|::....:|...:.....|.
 Frog   257 D-INRPNVSGATPL-------YFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETC 313

  Fly   285 TAESVESEAEPE--------EEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVI 341
               .:..:..|.        .:::|:..:.....|..|.....||.|..   :..:.|..|::..
 Frog   314 ---DILIQHHPRLFQTLIQMTQNEDLRENTLRQVLEHLSQQSEVQYLKI---LTGLAEVATTNGH 372

  Fly   342 QL----SDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPK--------------- 387
            :|    |.:...|:: ..|::......|.:..::.|:..||.|.....|:
 Frog   373 KLLSISSSYEAQMKS-LLRIVRIFCHVFRIGPSSPNNGNDMGYNGNKTPRNQVFKVRNVYDVFRK 436

  Fly   388 -------------LCQAASAMPVPAQARLARIWAAHCSDQLHSLIA-------------AC---- 422
                         :.||.|     .|..|..:|  |..|:...|||             ||
 Frog   437 INIKEMNLPNHTLIYQATS-----EQDPLELLW--HSLDEWLVLIATELTKNKRDSSNIACILLK 494

  Fly   423 -----QQQITL--QVLLDEESMRENESIISVTKVLKIVFYANILASELERPSC-----RVPLEDR 475
                 ||.|:|  |..:.|....::.|  |.|:           |.:.|  ||     :.|:.|.
 Frog   495 QNQLDQQDISLAHQSAIGESGSYDHLS--SSTR-----------AEDFE--SCSAAGKQEPVADG 544

  Fly   476 TE--AATASGSAAVEDDLFVYNSLLEPH---MPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEA 535
            .:  :.||:..:||....::..|...|.   .|:|.|...:.:..:.....|.|.|..:.|:
 Frog   545 QDVISMTANRLSAVIQAFYMCCSCQMPQGMTSPRFIEFVCKHDDVLKCFVTRNPKIIFDHFH--- 606

  Fly   536 LSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSL 600
                                                 |:|.....:....:..:.:.:.||....
 Frog   607 -------------------------------------FLLECPELMSRFMHIIKAQPFKERCEWF 634

  Fly   601 HSILNNIGQVGQEDNP---RP----DLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVG 658
            :..|    ..||.|:.   ||    |: |.|.||.:...:   .|:|..||.:.||:.:.|.|.|
 Frog   635 YEHL----LAGQPDSDMVHRPVNENDI-LLVHRDSIFRSS---CEVVFKSNCEKLKQGIAVRFHG 691

  Fly   659 EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQ---FTLIGIIIGLAI 720
            |:|:.: ||.:|:|.::..||.||.:.:|.|..:......|:....|...   |...|.|:|||:
 Frog   692 EEGMGQ-GVVREWFDILSSEIINPDYALFTQSADGTTFQPNSNSSVNPDHLNYFRFAGEILGLAL 755

  Fly   721 YNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDV 785
            |:...:.:.|....|:.::|....:.|::...|...|:|:.:||....|:.  .|.||.:. :||
 Frog   756 YHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLG--LELTFSVE-TDV 817

  Fly   786 FGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRP 850
            ||.:.:..|.|.|..:||.|.||..:|.|.::..:...|:.|.|.|.:||.|....|.:: ||..
 Frog   818 FGAMEEVPLKPGGASILVTQENKAEYVQLVTELRMTRAIQPQINGFLQGFHMFIPPSLIQ-LFDE 881

  Fly   851 EEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPV 915
            .|:|:|:.|..|.|..:...:|.|..||....|.||.||.:|..:..|::..||:|.|||:|||.
 Frog   882 YELELLLSGMPEIDVNDWMKNTEYTSGYERDDQVIQWFWEVVQELTQEERVLLLQFVTGSSRVPH 946

  Fly   916 G---------GLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINY-SKGF 970
            |         ||:...:....:.|  :.||||.||.|:|.||||.|:|.|::||:.|::. |.|:
 Frog   947 GGFAYIMGGSGLQNFTIAAVAYTP--NLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 1009

  Fly   971 GM 972
            .|
 Frog  1010 TM 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	13/65 (20%)
		HECTc	620..971	CDD:238033	121/363 (33%)
hace1	XP_012818577.2	ANKYR	66..317	CDD:440430	42/265 (16%)
		ANK repeat	134..163	CDD:293786	5/28 (18%)
		ANK repeat	165..196	CDD:293786	7/30 (23%)
		ANK repeat	198..229	CDD:293786	9/93 (10%)
		ANK repeat	231..262	CDD:293786	6/35 (17%)
		ANK repeat	264..289	CDD:293786	7/31 (23%)
		HECTc	657..1006	CDD:238033	119/359 (33%)