Protein Alignment Ube3a and Smurf1

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_006248944.1
• Gene: Smurf1 / 690516
• RGDID: 1594738
• Length: 757
• Species: Rattus norvegicus
• Alignment Length: 654
• Identity: 165/654 - (25%)
• Similarity: 288/654 - (44%)
• Gaps: 158/654 - (24%)

  Fly   431 LLDEESMRENESIISVTKVLKIVFYANI-----LASELERPSCRVPLEDRTEAATASGS-----A 485
            ::|...:.|||..:          |.:.     |:..:|.|:   |..|.|.||...|:     :
  Rat   149 VVDCRGLLENEGTV----------YEDSGPGRPLSCLMEEPA---PYTDGTGAAAGGGNCRFVES 200

  Fly   486 AVEDDLFVYNSLLEPHM----------------PKFAEDQFEKELQVSAIDCRKPLIPLEEFYNE 534
            ..:|...:...|..|.:                |:..|. :|:...|..           :.|..
  Rat   201 PSQDQRLLVQRLRNPEVRGSLQTPQNRPHGHQSPELPEG-YEQRTTVQG-----------QVYFL 253

  Fly   535 ALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFIL------------------------ 575
            .....:...||      ..:.|.:|:......:| ||.|:|
  Rat   254 HTQTGVSTWHD------PRIPSPLGTIPGGDEAF-LYEFLLQGHTSEPRDLNSVNCDELGPLPPG 311

  Fly   576 -----TPSTKVDALYYDSRMRMYSERYSSLHSILN---------------NIGQVGQEDNP---- 616
                 |.|.::..:.:::|...:::  ..||.|:|               :.|.|..|:.|
  Rat   312 WEVRSTVSGRIYFVDHNNRTTQFTD--PRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRY 374

  Fly   617 -----------RPDL----------KLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQ 660
                       |.:|          ::.|.|:::..::   ...:....||||||:|:|:|.||:
  Rat   375 ERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEES---YRQIMKMRPKDLKKRLMVKFRGEE 436

  Fly   661 GIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMW-------FNATPFENGAQFTLIGIIIGL 718
            |:|.|||::|:..|:..|:.||.:|:|  |..|:|::       .:..| ::.:.|..:|.|:||
  Rat   437 GLDYGGVAREWLYLLCHEMLNPYYGLF--QYSTDNIYTLQINPDSSINP-DHLSYFHFVGRIMGL 498

  Fly   719 AIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYS 783
            |:::...:...|.:..|::|:|.....:||....|.|:|||..:|:   .|:..|.:.||.:.:
  Rat   499 AVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILE---NDITPVLDHTFCVEH- 559

  Fly   784 DVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLF 848
            :.||.::||||.|||::|.|.:.||:.:|.||.::.....||.||.|.:|||..:..:..|| .|
  Rat   560 NAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PF 623

  Fly   849 RPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARV 913
            ..:|:|:::.|..:.|..:.:::|..:....: |..::.||..|.....|.:.:||:|.|||.||
  Rat   624 DQKELELIIGGLDKIDLNDWKSNTRLKHCVAD-SNIVRWFWQAVETFDEERRARLLQFVTGSTRV 687

  Fly   914 PVGGLKCLRLLITRHGP----------DSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSK 968
            |:.|.|.|:......||          ::|.||.:|||||.:.:|.|.|.|||.|:|:.|:..:.
  Rat   688 PLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC 752

  Fly   969 GFGM 972
            ||.:
  Rat   753 GFAV 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	121/377 (32%)
		HECTc	647..970	CDD:214523	115/339 (34%)
Smurf1	XP_006248944.1	C2_Smurf-like	14..138	CDD:176028
		WW	236..267	CDD:197736	6/48 (13%)
		WW	307..339	CDD:197736	3/33 (9%)
		HECTc	399..754	CDD:238033	119/366 (33%)
		HECTc	423..754	CDD:214523	115/339 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810